Mitsuo Shimada
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View article: Frailty as a predictor of postoperative aspiration pneumonia after abdominal surgery for digestive cancers
Frailty as a predictor of postoperative aspiration pneumonia after abdominal surgery for digestive cancers Open
This study was performed to investigate the factors associated with the development of postoperative aspiration pneumonia (PAP) after abdominal surgery for digestive cancers. The study involved 420 patients who had undergone abdominal surg…
View article: Clinical impact of rescue hepatectomy for local recurrence of hepatocellular carcinoma after radiofrequency ablation or selective transarterial chemoembolization
Clinical impact of rescue hepatectomy for local recurrence of hepatocellular carcinoma after radiofrequency ablation or selective transarterial chemoembolization Open
Background Local recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) or selective transarterial chemoembolization (sTACE) is relatively common. This study aimed to examine rescue hepatectomy as a treatment of s…
View article: Oligomeric Proanthocyanidins Reverse Lenvatinib Resistance in Hepatocellular Carcinoma Through ITGA3-Mediated Pathway
Oligomeric Proanthocyanidins Reverse Lenvatinib Resistance in Hepatocellular Carcinoma Through ITGA3-Mediated Pathway Open
Background: Oligomeric proanthocyanidins (OPCs) are natural polyphenolic compounds with strong antitumor properties and have gained attention as potential agents to overcome drug resistance. Hepatocellular carcinoma (HCC) remains a major c…
View article: Comparative Study of Laparoscopic Hepatectomy, Open Hepatectomy, and Percutaneous Radiofrequency Ablation for Small Hepatocellular Carcinoma: An Ancillary Study of the SURF Trial
Comparative Study of Laparoscopic Hepatectomy, Open Hepatectomy, and Percutaneous Radiofrequency Ablation for Small Hepatocellular Carcinoma: An Ancillary Study of the SURF Trial Open
Background: Laparoscopic hepatectomy (LH) for hepatocellular carcinoma (HCC) is increasing. To evaluate the efficacy of LH for small HCC (≤3 tumors within ≤3 cm), we compared short- and long-term outcomes between LH, open hepatectomy (OH),…
View article: Usefulness of transanal approach for lower rectal cancer: a propensity score-matched analysis
Usefulness of transanal approach for lower rectal cancer: a propensity score-matched analysis Open
Aim: Transanal approaches, such as transanal total mesorectal excision and transperineal abdominoperineal resection, have been developed to improve surgical quality for lower rectal cancer. However, international concerns have been raised …
View article: A Newly Launched Nationwide Database Revealed Real-world Evidence on Systemic Therapy for Unresectable Hepatocellular Carcinoma in Japan: Hepatoma Registry of Integrating and Aggregating Electronic Health Record (HERITAGE)
A Newly Launched Nationwide Database Revealed Real-world Evidence on Systemic Therapy for Unresectable Hepatocellular Carcinoma in Japan: Hepatoma Registry of Integrating and Aggregating Electronic Health Record (HERITAGE) Open
Background & Aims As systemic therapy for hepatocellular carcinoma (HCC) rapidly advances, eight treatment regimens are currently approved in Japan. However, the limited settings of phase III clinical trials necessitate large-scale real-wo…
View article: International multidisciplinary consensus recommendations on clinical application of three-dimensional visualization in precision surgery for pediatric liver tumors
International multidisciplinary consensus recommendations on clinical application of three-dimensional visualization in precision surgery for pediatric liver tumors Open
This consensus will standardize the application of 3D visualization technology in precision surgery for pediatric liver tumors to improve outcomes and reduce risks.
View article: Alteration of Apparent Diffusion Coefficient Measurements Predict Survival Outcomes During Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
Alteration of Apparent Diffusion Coefficient Measurements Predict Survival Outcomes During Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Open
We identified the clinical importance of changes in ADC values as a predictor of survival outcomes in patients with LARC. These results highlight the clinical importance of ADC values on improving the treatment strategies of patients.
View article: Vascular endothelial growth factor released from lenvatinib‐resistant hepatocellular carcinoma promotes malignant behavior and drug resistance through tumor‐associated macrophages
Vascular endothelial growth factor released from lenvatinib‐resistant hepatocellular carcinoma promotes malignant behavior and drug resistance through tumor‐associated macrophages Open
Aim Lenvatinib is one of the molecularly targeted drugs used worldwide in hepatocellular carcinoma (HCC) treatment, but the acquisition of drug resistance is a major problem. The mechanisms that make HCC lenvatinib‐resistant (LR) in the tu…
View article: The combination of CD8 and TIM3 expression predicts survival outcomes in hepatocellular carcinoma
The combination of CD8 and TIM3 expression predicts survival outcomes in hepatocellular carcinoma Open
The combination of CD8 and TIM3 expression which indicates T cell exhaustion was useful biomarker for predicting HCC prognosis than PD-1/PD-L1, suggesting that TIM3 may be a future target for immune checkpoint inhibition. J. Med. Invest. 7…
View article: Potential effect of Ninjin’yoeito on the postoperative state of hepatectomy in a naturally aged mouse model of frailty
Potential effect of Ninjin’yoeito on the postoperative state of hepatectomy in a naturally aged mouse model of frailty Open
NYT may affect the postoperative state, including body weight and motor function, in aged model mice. Suppression of HMGB1 might affect postoperative survival. J. Med. Invest. 72 : 245-251, August, 2025.
View article: The relationship between the tumor microenvironment of hepatocellular carcinoma - including cancer-associated fibroblasts and tumor-associated macrophages - and apparent diffusion coefficient
The relationship between the tumor microenvironment of hepatocellular carcinoma - including cancer-associated fibroblasts and tumor-associated macrophages - and apparent diffusion coefficient Open
The tumor microenvironment is critical for the acquisition of tumor malignancy in various cancer types. The objectives of this study were to investigate whether the levels of cancer-associated fibroblasts (CAFs) and tumor-associated macrop…
View article: Benign focal small bowel lesions : a review of the features on multiphasic multidetector computed tomography
Benign focal small bowel lesions : a review of the features on multiphasic multidetector computed tomography Open
The detection of small bowel lesions and their discrimination from normal bowel tissue are the most elementary and important factors in the computed tomography (CT) diagnosis of focal small bowel lesions. The detection and characterization…
View article: Farnesoid X receptor agonist accelerates ammonium metabolism of mesenchymal stem cell-derived hepatocyte-like cells
Farnesoid X receptor agonist accelerates ammonium metabolism of mesenchymal stem cell-derived hepatocyte-like cells Open
FXR agonist, OCA, accelerates ammonium metabolism of ADSCs derived HLCs. HLCs could be one of treatment options of hepatic encephalopathy of patients with liver failure or urea cycle disorder in the future. J. Med. Invest. 72 : 54-59, Febr…
View article: The number of teeth is a prognostic indicator for chemotherapy in colorectal cancer
The number of teeth is a prognostic indicator for chemotherapy in colorectal cancer Open
The number of teeth could be easily examined prognostic factor for chemotherapy in colorectal cancer. J. Med. Invest. 72 : 134-138, February, 2025.
View article: Impact of pure desmoplastic histological growth patterns in colorectal liver metastasis
Impact of pure desmoplastic histological growth patterns in colorectal liver metastasis Open
Pure desmoplastic HGP might be a good prognostic marker in CRLM.
View article: Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI
Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI Open
The utility of the apparent diffusion coefficient (ADC) of diffusion-weighted image (DWI) magnetic resonance imaging was examined for evaluating malignancy and prognosis in gallbladder tumors. A total of 63 patients (benign tumors, n=33; c…
View article: Lenvatinib‐resistant hepatocellular carcinoma promotes malignant potential of tumor‐associated macrophages via exosomal <scp>miR</scp>‐301a‐3p
Lenvatinib‐resistant hepatocellular carcinoma promotes malignant potential of tumor‐associated macrophages via exosomal <span>miR</span>‐301a‐3p Open
Background The interactions between cancer cells and tumor‐associated macrophages (TAMs) via microRNAs (miRNAs) play crucial roles in malignant potential and drug resistance. However, it remains unclear how lenvatinib‐resistant hepatocellu…
View article: A novel scoring system to predict short-term mortality after living donor liver transplantation for acute liver failure
A novel scoring system to predict short-term mortality after living donor liver transplantation for acute liver failure Open
Liver transplantation is often the only lifesaving option for acute liver failure (ALF); however, the predictors of short-term mortality (death within one year) after living donor liver transplantation (LDLT) for ALF have yet to be defined…
View article: Oncological Resectability Criteria for Hepatocellular Carcinoma in the Era of Novel Systemic Therapies: The Japan Liver Cancer Association and Japanese Society of Hepato-Biliary-Pancreatic Surgery Expert Consensus Statement 2023
Oncological Resectability Criteria for Hepatocellular Carcinoma in the Era of Novel Systemic Therapies: The Japan Liver Cancer Association and Japanese Society of Hepato-Biliary-Pancreatic Surgery Expert Consensus Statement 2023 Open
Recent advances in systemic therapy for hepatocellular carcinoma (HCC) have led to debates about the feasibility of combination therapies, such as systemic therapy combined with surgery or transarterial chemoembolization, for patients with…
View article: Generation of Highly Functional Hepatocyte-like Organoids from Human Adipose-Derived Mesenchymal Stem Cells Cultured with Endothelial Cells
Generation of Highly Functional Hepatocyte-like Organoids from Human Adipose-Derived Mesenchymal Stem Cells Cultured with Endothelial Cells Open
Previously, we successfully established a highly functional, three-dimensional hepatocyte-like cell (3D-HLC) model from adipose-derived mesenchymal stem cells (ADSCs) via a three-step differentiation protocol. The aim of the present study …
View article: Outcomes of remnant pancreatic resection for recurrent pancreatic cancer
Outcomes of remnant pancreatic resection for recurrent pancreatic cancer Open
Background Although there have been reports that remnant pancreatic resection for recurrence of pancreatic cancer contributes to a prolonged favorable prognosis, its surgical indications and timing remain controversial. We examined the fea…
View article: Preoperative evaluation to determine the difficulty of No. 6 lymphadenectomy in laparoscopic gastrectomy
Preoperative evaluation to determine the difficulty of No. 6 lymphadenectomy in laparoscopic gastrectomy Open
Background Laparoscopic gastrectomy (LG) requires a long learning curve because of the complicated surgical procedures. Infrapyloric (No. 6) lymph node dissection (LND) is one of the difficult procedures in LG, especially for trainees. Thi…
View article: Blue light irradiation inhibits the activation of cancer-associated macrophages in colon cancer
Blue light irradiation inhibits the activation of cancer-associated macrophages in colon cancer Open
Recent studies have shown that blue light-emitting diode (LED) light has anti-tumor effects, suggesting the possibility of using visible light in cancer therapy. However, the effects of blue light irradiation on cells in the tumor microenv…