Explanipedia

Prepulse inhibition of the blink reflex in functional neurological disorder and fibromyalgia Open

Lucia Nováková, David Voženílek, Tomáš Sieger, Ladislav Šenolt, Tereza Serranová · 2025

Prepulse inhibition reflects subcortical sensory integration, where a low-intensity peripheral stimulus (prepulse) reduces the amplitude of a reflex response to a subsequent high-intensity stimulus. As a measure of pre-attentive sensory ga…

Unrecognised Burden: High Prevalence and Clinical Impact of Fibromyalgia in Functional Motor Disorder Open

Tereza Serranová, Lucia Nováková, Martin Jirásek, Barbora Krupkova, Evžen Růžička , et al. · 2025

Background Fibromyalgia is a chronic pain disorder, affecting 2-3% of the population, characterised by widespread pain, fatigue, sleep and cognitive symptoms. Despite symptom overlap between functional motor disorder (FMD) and fibromyalgia…

The impact of motor and non-motor symptoms fluctuations on health-related quality of life in people with functional motor disorder Open

Martin Jirásek, Tomáš Sieger, Gabriela Chaloupková, Lucia Nováková, Petr Sojka , et al. · 2024

Objective: To assess the effect of overall, between- and within-day subjectively rated fluctuations in motor and non-motor symptoms in people with functional motor disorder (FMD) on the health-related quality of life (HRQoL). Background: F…

Sleepiness and comorbid sleep disorders in functional motor disorders: a comparative study with central hypersomnia Open

Jiří Nepožitek, Simona Dostálová, Gabriela Věchetová, Tomáš Sieger, Zuzana Forejtová , et al. · 2023

Summary Sleep symptoms, including excessive sleepiness, are frequently reported by patients with functional motor disorders (FMD). We aimed to classify the comorbid sleep disorders in FMD, and to investigate the relationship between subjec…

Improving fMRI in Parkinson’s disease by accounting for brain region-specific activity patterns Open

Renzo Torrecuso, Karsten Mueller, Štefan Holiga, Tomáš Sieger, Josef Vymazal , et al. · 2023

In functional magnetic imaging (fMRI) in Parkinson's disease (PD), a paradigm consisting of blocks of finger tapping and rest along with a corresponding general linear model (GLM) is often used to assess motor activity. However, this metho…

Improving fMRI in Parkinson’s Disease by Accounting for Brain Region-Specific Activity Patterns Open

Renzo Torrecuso, Karsten Mueller, Štefan Holiga, Tomáš Sieger, Josef Vymazal , et al. · 2022

In functional magnetic imaging (fMRI) in Parkinson’s disease (PD), a paradigm consisting of blocks of finger tapping and rest along with a corresponding general linear model (GLM) is often used to assess motor activity. However, this metho…

Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March–October 2020: An exploratory analysis Open

Martin Modrák, Paul‐Christian Bürkner, Tomáš Sieger, Tomáš Slisz, Martina Vašáková , et al. · 2021

We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested positive for SARS-CoV-2 during the early phases of the pandemic in March—October 2020. The dataset con…

The sensitivity of ECG contamination to surgical implantation site in brain computer interfaces Open

Wolf‐Julian Neumann, Majid Memarian Sorkhabi, Moaad Benjaber, Lucia K. Feldmann, Assel Saryyeva , et al. · 2021

Speech Perception and Production in Cochlear Implant Recipients with Pendred Syndrome Open

J Skrĭvan, Michal Jurovčík, Zdenka Aksenovová, Jaromı́r Astl, Radka Kremlíková Pourová , et al. · 2021

In this study evaluating language and speech production and acquisition, patients with Pendred syndrome who underwent cochlear implants show comparable results to their implanted peers with deafness of a different etiology.

Nucleoporin TPR Affects C2C12 Myogenic Differentiation via Regulation of Myh4 Expression Open

Jana Uhlířová, Lenka Šebestová, Karel Fišer, Tomáš Sieger, Jindřiška Fišerová , et al. · 2021

The nuclear pore complex (NPC) has emerged as a hub for the transcriptional regulation of a subset of genes, and this type of regulation plays an important role during differentiation. Nucleoporin TPR forms the nuclear basket of the NPC an…

The effects of interventional mitral valve repair using the MitraClip System on the results of pulmonary function testing, pulmonary pressure and diffusing capacity of the lung Open

Lucie Kretzler, Stephan Große, Stephan Wiedemann, Carsten Wunderlich, Christopher Nowak , et al. · 2021

GPU-Accelerated Mahalanobis-Average Hierarchical Clustering Analysis Open

Adam Šmelko, Miroslav Kratochvíl, Martin Kruliš, Tomáš Sieger · 2021

Detailed disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic: An exploratory analysis Open

Martin Modrák, Paul‐Christian Bürkner, Tomáš Sieger, Tomáš Slisz, Martina Vašáková , et al. · 2020

We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested positive for SARS-CoV-2. The dataset contains baseline patient characteristics, breathing support requ…

ShinySOM: graphical SOM-based analysis of single-cell cytometry data Open

Miroslav Kratochvíl, David Bednárek, Tomáš Sieger, Karel Fišer, Jiřı́ Vondrášek · 2020

Summary ShinySOM offers a user-friendly interface for reproducible, high-throughput analysis of high-dimensional flow and mass cytometry data guided by self-organizing maps. The software implements a FlowSOM-style workflow, with improvemen…

Topography of emotional valence and arousal within the motor part of the subthalamic nucleus in Parkinson’s disease Open

Tereza Serranová, Tomáš Sieger, Filip Růžička, Eduard Bakštein, Petr Dušek , et al. · 2019

Clinical motor and non-motor effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD) seem to depend on the stimulation site within the STN. We analysed the effects of the position of the stimula…

Nuclear pore protein TPR associates with lamin B1 and affects nuclear lamina organization and nuclear pore distribution Open

Jindřiška Fišerová, Miloslava Maninová, Tomáš Sieger, Jana Uhlířová, Lenka Šebestová , et al. · 2019

Chromatin organization at the nuclear periphery as revealed by image analysis of structured illumination microscopy data Open

Jindřiška Fišerová, Michaela Efenberková, Tomáš Sieger, Miloslava Maninová, Jana Uhlířová , et al. · 2017

The nuclear periphery (NP) plays a substantial role in chromatin organization. Heterochromatin at the NP is interspersed with active chromatin surrounding nuclear pore complexes (NPCs); however, details of the peripheral chromatin organiza…

Interactive Dendrograms: The R Packages idendro and idendr0 Open

Tomáš Sieger, Catherine Hurley, Karel Fišer, Claudia Beleites · 2017

Hierarchical cluster analysis is a valuable tool for exploring data by describing their structure using a dendrogram. However, proper visualization and interactive inspection of the dendrogram are needed to unlock the information in the da…

Microelectrode recording (MER) and electrooculography (EOG) signal acquisition and processing. Open

Tomáš Sieger, Cécilia Bonnet, Tereza Serranová, Jiří Wild, Daniel Novák , et al. · 2015

Action potentials of individual neurons were identified using the WaveClus algorithm in the MER signal. The instantaneous firing rate (IFR) was then estimated by convolving a series of extracted action potentials generated by a single neur…

Predicting Falls in Parkinson Disease: What Is the Value of Instrumented Testing in OFF Medication State? Open

Martina Hoskovcová, Petr Dušek, Tomáš Sieger, Hana Brožová, Kateřina Zárubová , et al. · 2015

Incorporating instrumented gait measures into the baseline assessment battery as well as accounting for both OFF and ON medication states might improve future fall prediction in PD patients. However, instrumented testing in the OFF state i…

Dysfunctional motor and cognitive networks in Parkinson's disease detected by resting state fMRI Open

Robert Jech, Filip Růžička, Ondřej Bezdíček, Tomáš Sieger, Josef Vymazal , et al. · 2015

Anxiety and salivary cortisol changes in Parkinson's disease are related to global connectivity of the ventromedial prefrontal network Open

Filip Růžička, Ondřej Bezdíček, Jan Roth, Tomáš Sieger, Josef Vymazal , et al. · 2015

Distinct populations of neurons respond to emotional valence and arousal in the human subthalamic nucleus Open

Tomáš Sieger, Tereza Serranová, Filip Růžička, Pavel Vostatek, Jiří Wild , et al. · 2015

Significance The involvement of the subthalamic nucleus (STN) in affective processing has been suggested with the appearance of neuropsychiatric side effects of deep brain stimulation in Parkinson’s disease (PD), but direct evidence has be…

External validation of extended prostate biopsy nomogram Open

Jan Hrbáček, Ivo Minárik, Tomáš Sieger, Marek Babjuk · 2015

The nomogram yielded overall good predictive accuracy as measured by the area under the ROC curve, but it systematically overestimated PC probability in individual patients. However, we showed how the nomogram could easily be adapted to ou…

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