Michael K. Skinner
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View article: Generational stability of environmentally induced epigenetic transgenerational inheritance of adult-onset disease over ten mammalian generations
Generational stability of environmentally induced epigenetic transgenerational inheritance of adult-onset disease over ten mammalian generations Open
In traditional models of Drosophila flies and Caenorhabditis elegans worms, epigenetic transgenerational inheritance has persisted for hundreds of generations. Mammalian studies, however, have primarily investigated up to three or four gen…
View article: Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution
Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution Open
The epigenome and epigenetic inheritance were not included in the original modern synthesis theory or more recent extended evolutionary synthesis of evolution. In a broad range of species, the environment has been shown to play a significa…
View article: Epigenetic transgenerational inheritance of toxicant exposure-specific non-coding RNA in sperm
Epigenetic transgenerational inheritance of toxicant exposure-specific non-coding RNA in sperm Open
Environmentally induced epigenetic transgenerational inheritance of phenotypic variation and disease susceptibility requires the germ cell (sperm or egg) transmission of integrated epigenetic mechanisms involving DNA methylation, histone m…
View article: Epigenetic biomarker for preeclampsia-associated preterm birth and potential preventative medicine
Epigenetic biomarker for preeclampsia-associated preterm birth and potential preventative medicine Open
Preterm birth (PTB) has dramatically increased within the population (i.e. >10%) and preeclampsia is a significant sub-category of PTB. Currently, there are no practical clinical parameters or biomarkers which predict preeclampsia induc…
View article: Could the sperm epigenome become a diagnostic tool for evaluation of the infertile man?
Could the sperm epigenome become a diagnostic tool for evaluation of the infertile man? Open
Although male infertility is currently diagnosed when abnormal sperm parameters are found, the poor predictive ability of sperm parameters on natural fecundity and medically assisted reproduction outcome poses the need for improved diagnos…
View article: Epigenome-wide association study of systemic effects of obesity susceptibility in human twins
Epigenome-wide association study of systemic effects of obesity susceptibility in human twins Open
The current study was designed to use an epigenome-wide association approach (EWAS) to identify potential systemic DNA methylation alterations that are associated with obesity using 22 discordant twin pairs. Buccal cells (from a cheek swab…
View article: Systemic epigenome-wide association study of elk treponeme-associated hoof disease
Systemic epigenome-wide association study of elk treponeme-associated hoof disease Open
Treponeme-associated hoof disease (TAHD) is an emerging disease of elk ( Cervus canadensis ) in the U.S. Pacific West. Because environmental epigenetics is the primary molecular process that mediates environmental factor impacts on a host …
View article: Epigenetic Inheritance and Transgenerational EnvironmentalJustice
Epigenetic Inheritance and Transgenerational EnvironmentalJustice Open
Many chemicals and toxicants are released into our ecosystem and environment every day, which can cause harmful effects on human populations. Agricultural compounds are used in most crop production and have been shown to cause negative hea…
View article: Multiple generation distinct toxicant exposures induce epigenetic transgenerational inheritance of enhanced pathology and obesity
Multiple generation distinct toxicant exposures induce epigenetic transgenerational inheritance of enhanced pathology and obesity Open
Three successive multiple generations of rats were exposed to different toxicants and then bred to the transgenerational F5 generation to assess the impacts of multiple generation different exposures. The current study examines the actions…
View article: Epigenome-wide association study of systemic effects of obesity susceptibility in human twins
Epigenome-wide association study of systemic effects of obesity susceptibility in human twins Open
The current study was designed to use an epigenome-wide association approach (EWAS) to identify potential systemic DNA methylation alterations that are associated with obesity using 22 discordant twin pairs. Buccal cells (from a cheek swab…
View article: Transgenerational sperm DMRs escape DNA methylation erasure during embryonic development and epigenetic inheritance
Transgenerational sperm DMRs escape DNA methylation erasure during embryonic development and epigenetic inheritance Open
Germline transmission of epigenetic information is a critical component of epigenetic inheritance. Previous studies have suggested that an erasure of DNA methylation is required to develop stem cells in the morula embryo. An exception invo…
View article: Identifying unique exposure-specific transgenerational differentially DNA methylated region epimutations in the genome using hybrid deep learning prediction models
Identifying unique exposure-specific transgenerational differentially DNA methylated region epimutations in the genome using hybrid deep learning prediction models Open
Exposure to environmental toxicants can lead to epimutations in the genome and an increase in differential DNA methylated regions (DMRs) that have been linked to increased susceptibility to various diseases. However, the unique effect of p…
View article: A case study approach to understanding the pathway to individualised funded supports under the National Disability Insurance Scheme for community-dwelling individuals with acquired brain injury
A case study approach to understanding the pathway to individualised funded supports under the National Disability Insurance Scheme for community-dwelling individuals with acquired brain injury Open
Background: The National Disability Insurance Scheme (NDIS) offers opportunity against a historical background of underfunded and fragmented services for people with disability. For people with acquired brain injury (ABI), concerns have be…
View article: Developmental alterations in DNA methylation during gametogenesis from primordial germ cells to sperm
Developmental alterations in DNA methylation during gametogenesis from primordial germ cells to sperm Open
Because epigenetics is a critical component for gene expression, the hypothesis was tested that DNA methylation alterations are dynamic and continually change throughout gametogenesis to generate the mature sperm. Developmental alterations…
View article: Role of epigenetic transgenerational inheritance in generational toxicology
Role of epigenetic transgenerational inheritance in generational toxicology Open
Many environmental toxicants have been shown to be associated with the transgenerational inheritance of increased disease susceptibility. This review describes the generational toxicity of some of these chemicals and their role in the indu…