Maâmar Souidi
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View article: Presymptomatic microRNA-based biomarker signatures for the prognosis of localized radiation injury in mice
Presymptomatic microRNA-based biomarker signatures for the prognosis of localized radiation injury in mice Open
The threat of nuclear or radiological events requires early diagnostic tools for radiation induced health effects. Localized radiation injuries (LRI) are severe outcomes of such events, characterized by a latent presymptomatic phase follow…
View article: Long-term biological effects after acute <sup>131</sup> I-administration of two rat models (with and without thyroid)
Long-term biological effects after acute <sup>131</sup> I-administration of two rat models (with and without thyroid) Open
Long-term biological effect of 131I-administration shows the appearance of various histological disorders confirmed by disturbances in hepatic and renal functions.
View article: Review of the PRIODAC project on thyroid protection from radioactive iodine by repeated iodide intake in individuals aged 12+
Review of the PRIODAC project on thyroid protection from radioactive iodine by repeated iodide intake in individuals aged 12+ Open
Background Intake of potassium iodide (KI) reduces the accumulation of radioactive iodine in the thyroid gland in the event of possible contamination by radioactive iodine released from a nuclear facility. The World Health Organization (WH…
View article: Potassium iodide (KI) prophylaxis in the case of a nuclear accident: A new marketing authorization in France
Potassium iodide (KI) prophylaxis in the case of a nuclear accident: A new marketing authorization in France Open
Prophylaxis by “KI 65 mg, breakable tablet” is a pharmacological countermeasure of radiological protection adapted for the prevention of thyroid cancer after exposure to radioactive iodine. A first modification of the marketing authorizati…
View article: Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats
Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats Open
Male infertility is a major public health issue that can be induced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. Regarding the human population exposed to uranium, it is nec…
View article: Use of omics analysis for low-dose radiotoxicology and health risk assessment: the case of uranium
Use of omics analysis for low-dose radiotoxicology and health risk assessment: the case of uranium Open
Exposure to environmental pollution and the increase in the incidence of multifactorial diseases in the population have become health problems for industrialized countries. In this context, the question of the health impact of exposure to …
View article: Protection and safety of a repeated dosage of KI for iodine thyroid blocking during pregnancy
Protection and safety of a repeated dosage of KI for iodine thyroid blocking during pregnancy Open
In case of nuclear power plant accidents resulting in the release of radioactive iodine ( 131 I) in large amounts, a single intake of stable iodine is recommended in order to prevent 131 I fixation to the thyroid gland. However, in situati…
View article: Muricholic Acids Promote Resistance to Hypercholesterolemia in Cholesterol-Fed Mice
Muricholic Acids Promote Resistance to Hypercholesterolemia in Cholesterol-Fed Mice Open
Background and aims: Hypercholesterolemia is a major risk factor for atherosclerosis and cardiovascular diseases. Although resistant to hypercholesterolemia, the mouse is a prominent model in cardiovascular research. To assess the contribu…
View article: From metabolome to epigenome: example of multiscale analysis for studying the effects of low-dose uranium exposure
From metabolome to epigenome: example of multiscale analysis for studying the effects of low-dose uranium exposure Open
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View article: Effect of repetitive potassium iodide on thyroid and cardiovascular functions in elderly rats
Effect of repetitive potassium iodide on thyroid and cardiovascular functions in elderly rats Open
Our results indicate that repeated ITB in elderly rats is characterized by molecular modifications of cardiovascular key actors, particularly the Renin-angiotensin-aldosterone axis with a preserved physiological homeostasis. This new scien…
View article: Effects of repetitive Iodine Thyroid Blocking on the Development of the Foetal Brain and Thyroid in rats: a Systems Biology approach
Effects of repetitive Iodine Thyroid Blocking on the Development of the Foetal Brain and Thyroid in rats: a Systems Biology approach Open
A single dose of potassium iodide (KI) against repeated exposure to radioactive iodine, such as the one of the Fukushima accident, might not be effective enough to protect the thyroid. Our group showed that repetitive dose of KI for eight …
View article: A systems biology approach to propose a new mechanism of regulation of repetitive prophylaxis of stable iodide on sodium/iodide symporter (NIS)
A systems biology approach to propose a new mechanism of regulation of repetitive prophylaxis of stable iodide on sodium/iodide symporter (NIS) Open
Our group showed that repetitive dose of potassium iodide (KI) for eight days offers an efficient protection for exposure to repeated radioactive emissions without adverse effects on adult rats. However, differential expression of genes im…
View article: A putative mechanism of the Sodium/Iodide Symporter regulation during repetitive administration of stable Iodide described by a Systems Biology approach
A putative mechanism of the Sodium/Iodide Symporter regulation during repetitive administration of stable Iodide described by a Systems Biology approach Open
A single dose of potassium iodide (KI) against a prolonged exposure to repeated radioactivity might not be effective enough to protect the thyroid. Our group have shown that a repetitive dose of KI for eight days offers efficient protectio…
View article: Effect of repetitive potassium iodide on elderly rat’s thyroid
Effect of repetitive potassium iodide on elderly rat’s thyroid Open
Background : Nuclear power plant emergencies had often been accompanied by radioactivity release into the environment, thyroid cancer is one of the major health consequences due to the effect of radioactive iodine ( 131 I) that emits ϒ ray…
View article: Absorbed dose evaluation at different organs after <sup>131</sup>I oral contamination of two Wistar rat models
Absorbed dose evaluation at different organs after <sup>131</sup>I oral contamination of two Wistar rat models Open
Iodine-131 ( 131 I) is one of the most frequently used radionuclides for diagnosis and therapy of thyroid diseases. It is administered orally in the treatment of cancer to eliminate the residual postoperative microscopic tumor foci, and th…
View article: Optimal KI Prophylactic Dose Determination for Thyroid Radiation Protection After a Single Administration in Adult Rats
Optimal KI Prophylactic Dose Determination for Thyroid Radiation Protection After a Single Administration in Adult Rats Open
A dose–response study was performed in adult rats to select an optimal stable potassium iodide (KI) dose which could be implemented in repeated prophylaxis, in case of prolonged exposure to radioactive iodine. Increasing doses of KI were g…
View article: Endocrine effects of lifelong exposure to low-dose depleted uranium on testicular functions in adult rat
Endocrine effects of lifelong exposure to low-dose depleted uranium on testicular functions in adult rat Open
Environmental toxicant exposure can induce disorders in sex steroidogenesis during fetal gonad development. Our previous study demonstrated that chronic adult exposure to a supra environmental concentration of depleted uranium (DU) does no…
View article: Chronic exposure of adult, postnatal and in utero rat models to low-dose 137Cesium: impact on circulating biomarkers
Chronic exposure of adult, postnatal and in utero rat models to low-dose 137Cesium: impact on circulating biomarkers Open
The presence of 137Cesium (137Cs) in the environment after nuclear accidents at Chernobyl and more recently Fukushima Daiichi raises many health issues for the surrounding populations chronically exposed through the food chain. To mimic di…