Maria Kamusheva
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View article: Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria
Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria Open
Aims Late‐diagnosed diabetic retinopathy (DR) is difficult and expensive to treat. Screening programmes can identify the disease early and reduce the costs of its future treatment. This study aims to analyse the cost–benefit of screening p…
View article: Incorporating cost considerations into shared decision-making: lessons from Bulgaria
Incorporating cost considerations into shared decision-making: lessons from Bulgaria Open
This study aims to explore the need for and acceptability of incorporating treatment costs into shared decision-making (SDM) among patients and healthcare providers (HCPs) in Bulgaria. This study is a qualitative, non-interventional evalua…
View article: Optimizing Patient Access to Orphan Medicinal Products: Lessons from Central and Eastern Europe
Optimizing Patient Access to Orphan Medicinal Products: Lessons from Central and Eastern Europe Open
This study examines patient access to orphan medicinal products (OMPs) in Central and Eastern Europe (CEE) over the past five years, focusing on seven countries: Bulgaria, Czechia, Hungary, Poland, Romania, Slovakia, and Slovenia. While th…
View article: Awareness of herbal medicine within the Bulgarian population—a pilot study
Awareness of herbal medicine within the Bulgarian population—a pilot study Open
Background : Herbal medicine has been an integral part of Bulgarian life and culture for centuries. However, incorrect use, resulting from a lack of adequate or false understanding of medicinal plants’ therapeutic properties, poses serious…
View article: Assessment of medication adherence in patients with rare diseases: a systematic review
Assessment of medication adherence in patients with rare diseases: a systematic review Open
Background : The study aims to critically analyze the scientific literature concerning methods for assessing medication adherence (MA), the factors that influence it, medication adherence-enhancing interventions (MAEIs), and the consequenc…
View article: Does the Use of Psychoactive Substances Reveal Underlying Trauma or Common Mental Health Problems?
Does the Use of Psychoactive Substances Reveal Underlying Trauma or Common Mental Health Problems? Open
The paper evaluates the prevalence of psychoactive substance use in a non-clinical sample of university students and examines its relation to childhood traumatic experiences and common mental health problems. An anonymous online survey was…
View article: Pan‐European survey on medication adherence management by healthcare professionals
Pan‐European survey on medication adherence management by healthcare professionals Open
Aims While medication adherence (MA) is a key prerequisite for achieving optimal clinical and economic outcomes, nonadherence is highly prevalent. Assessing how healthcare professionals (HCPs) in Europe manage MA, focusing on measurement, …
Barriers and Unmet Educational Needs Regarding Implementation of Medication Adherence Management Across Europe: Insights from COST Action ENABLE Open
Background Medication adherence is essential for the achievement of therapeutic goals. Yet, the World Health Organization estimates that 50% of patients are nonadherent to medication and this has been associated with 125 billion euros and …
View article: Transferability of new methods for health technology assessment in the field of diabetes between early and late adopters’ countries
Transferability of new methods for health technology assessment in the field of diabetes between early and late adopters’ countries Open
This study aimed to investigate the transferability of novel artificial intelligence (AI) methods for prediction modelling of diabetes based on real-world data (RWD) between early and late adopters of emerging health technologies from the …
View article: Clinical aspects of reimbursement policies for orphan drugs in Central and Eastern European countries
Clinical aspects of reimbursement policies for orphan drugs in Central and Eastern European countries Open
Objectives: The aim of this study was to characterize the reimbursement policy for orphan drugs (ODs) in Central and Eastern European (CEE) countries in relation to the availability and impact of clinical evidence, health technology assess…
View article: Adherence to disease-modifying therapies among patients with multiple sclerosis in Bulgaria – A real world study
Adherence to disease-modifying therapies among patients with multiple sclerosis in Bulgaria – A real world study Open
Introduction : The purpose was to assess the level of medication adherence (MA) and related factors among individuals with multiple sclerosis (MS) in Bulgaria. Materials and methods : A prospective one-year study was conducted among 54 pat…
View article: Diabetes Mellitus—Digital Solutions to Improve Medication Adherence: Scoping Review
Diabetes Mellitus—Digital Solutions to Improve Medication Adherence: Scoping Review Open
Medication adherence (MA) is a major problem. On average 50% of chronic disease management medications are not taken as prescribed While digital healthcare tools like mobile apps offer benefits such as informative messages and prescription…
View article: Cost-effectiveness of treatment intervention in prediabetic patients in Bulgaria
Cost-effectiveness of treatment intervention in prediabetic patients in Bulgaria Open
Introduction : The study aims to evaluate the cost-effectiveness (CE) of an early intervention in prediabetes (metformin) in order to prevent or slow down the onset of diabetes in those at high risk compared with the current “do nothing” a…
View article: Recommendations for patient involvement in health technology assessment in Central and Eastern European countries
Recommendations for patient involvement in health technology assessment in Central and Eastern European countries Open
Introduction Meaningful patient involvement in health technology assessment (HTA) is essential in ensuring that the interests of the affected patient population, their families, and the general public are accurately reflected in coverage a…
View article: Medication Adherence among Patients with Diabetes Mellitus and Its Related Factors—A Real-World Pilot Study in Bulgaria
Medication Adherence among Patients with Diabetes Mellitus and Its Related Factors—A Real-World Pilot Study in Bulgaria Open
Background and Objectives: The objective is to evaluate medication adherence level (MA) and the relevant determinants of MA among patients with type 2 diabetes mellitus (T2DM) monitored in ambulatory settings by general practitioners. Mate…
View article: Cost-effectiveness of disease-modifying treatments for multiple sclerosis in Bulgaria based on evidence from real world settings
Cost-effectiveness of disease-modifying treatments for multiple sclerosis in Bulgaria based on evidence from real world settings Open
Background : This study aims to provide insight on the early application of high efficacy 2 nd line DMDs from Bulgarian public payer perspective, referring to RWD. Methods: An Excel-based model was developed to compare the effectiveness of…
View article: Ethnobotanical and Ethnopharmacological Study in the Bulgarian Mountain Rhodopes: Part II—Contemporary Use of Medicinal Plants
Ethnobotanical and Ethnopharmacological Study in the Bulgarian Mountain Rhodopes: Part II—Contemporary Use of Medicinal Plants Open
Rhodopes Mountain is ethnobotanically poorly studied, but our preliminary observation in a number of settlements revealed that even nowadays, the local population relies solely on previously collected medicinal plants. We aimed to assess t…
View article: Guidance on using real-world evidence from Western Europe in Central and Eastern European health policy decision making
Guidance on using real-world evidence from Western Europe in Central and Eastern European health policy decision making Open
Aim: Real-world data and real-world evidence (RWE) are becoming more important for healthcare decision making and health technology assessment. We aimed to propose solutions to overcome barriers preventing Central and Eastern European (CEE…
View article: Adherence to Acromegaly Treatment and Analysis of the Related Factors—A Real-World Study in Bulgaria
Adherence to Acromegaly Treatment and Analysis of the Related Factors—A Real-World Study in Bulgaria Open
The purpose was to assess the level of medication adherence (MA) and related factors among individuals with acromegaly. The secondary goal was to assess the quality of life of patients and whether and how it correlates with the level of ad…
View article: Methodological Quality of Retrospective Observational Studies Investigating Effects of Diabetes Monitoring Systems: a Systematic Review
Methodological Quality of Retrospective Observational Studies Investigating Effects of Diabetes Monitoring Systems: a Systematic Review Open
Background Retrospective observational studies (ROSs) have been frequently used to investigate treatment effects of diabetes monitoring systems (DMS), i.e. medical devices to monitor blood glucose. However, due to quality concerns, the fin…
View article: Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices
Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices Open
This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Econom…
View article: Cost-Effectiveness of Multiple Sclerosis Therapies – A Literature Review
Cost-Effectiveness of Multiple Sclerosis Therapies – A Literature Review Open
Multiple Sclerosis (MS) is the most prevalent chronic inflammatory disease of the central nervous system, characterized by demyelination, axonal damage and progressive disability. This literature review aims to provide an overview of cost-…
View article: Budget cap and pay-back model to control spending on medicines: A case study of Bulgaria
Budget cap and pay-back model to control spending on medicines: A case study of Bulgaria Open
Central and Eastern European countries (CEEC) have among the highest rates of increase in healthcare expenditure. External reference pricing, generics and biologics price capping, regressive scale for price setting, health technology asses…
View article: Potential Barriers of Patient Involvement in Health Technology Assessment in Central and Eastern European Countries
Potential Barriers of Patient Involvement in Health Technology Assessment in Central and Eastern European Countries Open
Patients' perspectives are important to identify preferences, estimate values and appreciate unmet medical needs in the process of research and development and subsequent assessment of new health technologies. Patient and public involvemen…
View article: Quality of life, control of treatment and satisfaction of patients with asthma in Bulgaria: a pilot study
Quality of life, control of treatment and satisfaction of patients with asthma in Bulgaria: a pilot study Open
This study aims to evaluate clinical characteristics, quality of life and control of treatment and therapy satisfaction of patients with asthma in Bulgaria. A pilot study of Bulgarian patients with asthma selected by allergologists was per…
View article: Barriers to Use Artificial Intelligence Methodologies in Health Technology Assessment in Central and East European Countries
Barriers to Use Artificial Intelligence Methodologies in Health Technology Assessment in Central and East European Countries Open
The aim of this paper is to identify the barriers that are specifically relevant to the use of Artificial Intelligence (AI)-based evidence in Central and Eastern European (CEE) Health Technology Assessment (HTA) systems. The study relied o…
View article: Using real-world evidence in healthcare from Western to Central and Eastern Europe: a review of existing barriers
Using real-world evidence in healthcare from Western to Central and Eastern Europe: a review of existing barriers Open
As part of the HTx (Next Generation Health Technology Assessment) project, this study was aimed at identifying the main barriers for application of real-world evidence (RWE) for the purposes of health technology assessment in the Central a…