Masahiko Takada
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View article: Dorsomedial striatum monitors unreliability of current action policy and probes alternative one via the indirect pathway
Dorsomedial striatum monitors unreliability of current action policy and probes alternative one via the indirect pathway Open
Previous studies revealed critical involvement of the striatum in adapting to the environment by actions that anticipate rewards from experiences as a policy. However, it remains unclear how current policy is evaluated to explore more adva…
View article: Drug discovery and development for Parkinson’s disease: are preclinical models good enough?
Drug discovery and development for Parkinson’s disease: are preclinical models good enough? Open
Parkinson’s disease (PD) remains a major challenge for translational neuroscience, with an increasing global prevalence and persistent unmet therapeutic needs. While its classical motor symptoms, such as bradykinesia, rigidity, and tremor,…
View article: Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Longitudinal assessment of DREADD expression and efficacy in the monkey brain Open
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) offer a powerful means for reversible control of neuronal activity through systemic administration of inert actuators. Because chemogenetic control relies on DREADD expre…
View article: Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Longitudinal assessment of DREADD expression and efficacy in the monkey brain Open
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) offer a powerful means for reversible control of neuronal activity through systemic administration of inert actuators. Because chemogenetic control relies on DREADD expre…
View article: Differential representation of motivation and affective judgment by neurons in the primate ventral striatum and ventral pallidum during approach-avoidance decision-making
Differential representation of motivation and affective judgment by neurons in the primate ventral striatum and ventral pallidum during approach-avoidance decision-making Open
Decision-making often involves evaluating trade-offs between potential rewards and aversive outcomes, engaging both motivational drive and affective judgment. The ventral striatum (VS) and ventral pallidum (VP) are key regions involved in …
View article: Retrograde Optogenetics Reveals Functional Convergence within a Corticotectal Pathway of Non-Human Primates
Retrograde Optogenetics Reveals Functional Convergence within a Corticotectal Pathway of Non-Human Primates Open
Summary Understanding how the cerebral cortex communicates with subcortical areas to drive behavior remains a central question in system neuroscience. One key unresolved issue is whether prefrontal cortical outputs to motor-related subcort…
View article: Three-dimensional markerless motion capture of multiple freely behaving monkeys toward automated characterization of social behavior
Three-dimensional markerless motion capture of multiple freely behaving monkeys toward automated characterization of social behavior Open
Given their high sociality and close evolutionary distance to humans, monkeys are an essential animal model for unraveling the biological mechanisms underlying human social behavior and elucidating the pathogenesis of diseases exhibiting a…
View article: Role of the primate ventral striatum as a neural hub bridging option valuation and action selection
Role of the primate ventral striatum as a neural hub bridging option valuation and action selection Open
Making appropriate decisions relies on the brain’s capacity to evaluate the expected outcomes of available options and select the most rewarding one. Reinforcement learning theory offers a computational framework for this process, wherein …
View article: Temporal–orbitofrontal pathway regulates choices across physical reward and visual novelty
Temporal–orbitofrontal pathway regulates choices across physical reward and visual novelty Open
Perceptually novel objects have profound impacts on our daily decisions. People often pay to try novel meals over familiar ones, or to see novel visual scenes at art exhibits and travel destinations. This suggests that perceptual novelty a…
View article: Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation
Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation Open
The ventral striatum (VS) is a key brain region for reward processing and motivation, and its dysfunctions have been implicated in psychiatric disorders such as apathy and obsessive–compulsive disorder. Although functional heterogeneity wi…
View article: Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Longitudinal assessment of DREADD expression and efficacy in the monkey brain Open
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) offer a powerful means for reversible control of neuronal activity through systemic administration of inert actuators. Because chemogenetic control relies on DREADD expre…
View article: Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Longitudinal assessment of DREADD expression and efficacy in the monkey brain Open
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) offer a powerful means for reversible control of neuronal activity through systemic administration of inert actuators. Because chemogenetic control relies on DREADD expre…
View article: Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations
Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations Open
Dopamine (DA) signals to the striatum play critical roles in shaping and sustaining stimulus-reward associations. In primates, however, the dynamics of the DA signals remain unknown since conventional methods are not necessarily appropriat…
View article: Scg2 drives reorganization of the corticospinal circuit with spinal premotor interneurons to recover motor function after stroke
Scg2 drives reorganization of the corticospinal circuit with spinal premotor interneurons to recover motor function after stroke Open
Brain injuries such as stroke damage neural circuitry and lead to functional deficits. Spared motor pathways are often reorganized and contribute to functional recovery; however, the connectivity and molecular mechanisms that drive the reo…
View article: Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Longitudinal assessment of DREADD expression and efficacy in the monkey brain Open
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) offer a powerful means for reversible control of neuronal activity through systemic administration of inert actuators. Because chemogenetic control relies on DREADD expre…
View article: The Prognostic Impact of Adipophilin Expression on Long-Term Survival Following Liver Resection in Patients with Colorectal Liver Metastases
The Prognostic Impact of Adipophilin Expression on Long-Term Survival Following Liver Resection in Patients with Colorectal Liver Metastases Open
Background/Objectives: Adipophilin (ADP) is a protein associated with lipid droplets, and its expression is related to poor prognosis in certain cancers. However, its impact on the survival of patients with colorectal liver metastases (CRL…
View article: Distinct roles of monkey OFC-subcortical pathways in adaptive behavior
Distinct roles of monkey OFC-subcortical pathways in adaptive behavior Open
Primates must adapt to changing environments by optimizing their behavior to make beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the brain, which updates choice value through direct experience or …
View article: Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex
Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex Open
Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective of whether the movements are task-relevant or task-irrelevant. To examine the extent to which movements and a primitive cogni…