Miguel Puga‐Tejada
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View article: Automated real-time imaging of intestinal barrier integrity and molecular profiling for early outcome prediction in inflammatory bowel disease: endo-histo-barrier-omics study
Automated real-time imaging of intestinal barrier integrity and molecular profiling for early outcome prediction in inflammatory bowel disease: endo-histo-barrier-omics study Open
Background Barrier healing is an emerging therapeutic target in inflammatory bowel disease (IBD), though its assessment remains challenging. We evaluated automated advanced imaging for real-time barrier assessment, its correlation with epi…
View article: Endo-Histo foundational fusion model: a novel artificial intelligence for assessing histologic remission and response to therapy in ulcerative colitis clinical trial
Endo-Histo foundational fusion model: a novel artificial intelligence for assessing histologic remission and response to therapy in ulcerative colitis clinical trial Open
Background and Aims Artificial intelligence (AI)-enabled endoscopy and histology offer accurate, objective, and rapid assessment of disease activity in ulcerative colitis (UC). Emerging multi-source AI models may enhance standardized disea…
View article: A Novel Switching of Artificial Intelligence to Generate Simultaneously Multimodal Images to Assess Inflammation and Predict Outcomes in Ulcerative Colitis—(With Video)
A Novel Switching of Artificial Intelligence to Generate Simultaneously Multimodal Images to Assess Inflammation and Predict Outcomes in Ulcerative Colitis—(With Video) Open
Objectives Virtual Chromoendoscopy (VCE) is pivotal for assessing activity and predicting outcomes in Ulcerative Colitis (UC), though interobserver variability and the need for expertise persist. Artificial intelligence (AI) offers standar…
View article: Proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug-induced ulcers and dyspepsia
Proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug-induced ulcers and dyspepsia Open
Protocol (2022): doi.org/10.1002/14651858.CD014585.
View article: Hepatocellular Carcinoma After HCV Eradication with Direct-Acting Antivirals: A Reappraisal Based on New Parameters to Assess the Persistence of Risk
Hepatocellular Carcinoma After HCV Eradication with Direct-Acting Antivirals: A Reappraisal Based on New Parameters to Assess the Persistence of Risk Open
Approximately 95% of patients with chronic hepatitis C achieve viral eradication through direct-acting antiviral (DAA) treatment. Ensuing clinical benefits include halting liver fibrosis, thereby reducing the need for liver transplantation…
View article: Rediscovering histology – the application of artificial intelligence in inflammatory bowel disease histologic assessment
Rediscovering histology – the application of artificial intelligence in inflammatory bowel disease histologic assessment Open
Integrating artificial intelligence (AI) into histologic disease assessment is transforming the management of inflammatory bowel disease (IBD). AI-aided histology enables precise, objective evaluations of disease activity by analysing whol…
View article: Comparative analysis of vibration-controlled transient elastography and EUS-shear wave elastography for liver stiffness measurement in cirrhosis
Comparative analysis of vibration-controlled transient elastography and EUS-shear wave elastography for liver stiffness measurement in cirrhosis Open
Background and Objectives Chronic liver inflammation leads to fibrosis and cirrhosis. To avoid portal hypertension-related complications, fibrosis' early detection is imperative. Biopsy remains the gold standard, but magnetic resonance ela…
View article: P0340 Endo-Histo Foundational Fusion Model: A Novel Artificial Intelligence Approach for Predicting Histologic Remission and Early Response to Therapy in a Phase 2 Ulcerative Colitis Clinical Trial
P0340 Endo-Histo Foundational Fusion Model: A Novel Artificial Intelligence Approach for Predicting Histologic Remission and Early Response to Therapy in a Phase 2 Ulcerative Colitis Clinical Trial Open
Background Artificial Intelligence (AI)- enabled endoscopy and histology offer accurate, objective, and rapid assessment of disease activity in Ulcerative Colitis (UC). Emerging multi-source AI models integrating diverse datasets may enhan…
View article: Artificial intelligence–enabled histology exhibits comparable accuracy to pathologists in assessing histological remission in ulcerative colitis: a systematic review, meta-analysis, and meta-regression
Artificial intelligence–enabled histology exhibits comparable accuracy to pathologists in assessing histological remission in ulcerative colitis: a systematic review, meta-analysis, and meta-regression Open
Background and Aims Achieving histological remission is a desirable emerging treatment target in ulcerative colitis (UC), yet its assessment is challenging due to high inter- and intraobserver variability, reliance on experts, and lack of …
View article: P0556 A novel switching of artificial intelligence to generate simultaneously multimodal images to assess inflammation and predict outcomes in Ulcerative Colitis
P0556 A novel switching of artificial intelligence to generate simultaneously multimodal images to assess inflammation and predict outcomes in Ulcerative Colitis Open
Background Virtual Chromoendoscopy (VCE) is pivotal for assessing activity and predicting outcomes in Ulcerative Colitis (UC), though inter- and intra-observer variability and the need for expertise persist. Artificial intelligence (AI) ha…
View article: DOP107 Real-time intestinal barrier assessment by endocytoscopy and confocal laser endomicroscopy uniquely correlates with multiple barrier protein expression and reflects the gut-brain axis
DOP107 Real-time intestinal barrier assessment by endocytoscopy and confocal laser endomicroscopy uniquely correlates with multiple barrier protein expression and reflects the gut-brain axis Open
Background The intestinal barrier is gaining recognition as a key indicator of mucosal healing in IBD. Nonetheless, its assessment remains challenging. This study evaluates advanced endoscopic tools for real-time gut barrier assessment, ex…
View article: Epithelial neutrophil localization and tight junction Claudin‐2 expression are innovative outcome predictors in inflammatory bowel disease
Epithelial neutrophil localization and tight junction Claudin‐2 expression are innovative outcome predictors in inflammatory bowel disease Open
Background Patients with inflammatory bowel disease (IBD) in clinical and endoscopic remission may still experience disease relapse. Therefore, there is a need to identify outcome predictors. Recently, the role of neutrophils in predicting…
View article: Endocytoscopy with automated multispectral intestinal barrier pathology imaging for assessment of deep healing to predict outcomes in ulcerative colitis
Endocytoscopy with automated multispectral intestinal barrier pathology imaging for assessment of deep healing to predict outcomes in ulcerative colitis Open
Endoscopy newsdetails and guide tissue sampling combined with automated barrier protein evaluation
View article: Artificial intelligence-enabled advanced endoscopic imaging to assess deep healing in inflammatory bowel disease
Artificial intelligence-enabled advanced endoscopic imaging to assess deep healing in inflammatory bowel disease Open
Endoscopic remission is the primary long-term therapeutic goal in inflammatory bowel disease (IBD). The assessment of this therapeutic target typically relies on white light endoscopy (WLE) combined with histological sampling. Nonetheless,…
View article: Accurate and safe diagnosis and treatment of neoplastic biliary lesions using a novel 9F and 11F digital single-operator cholangioscope
Accurate and safe diagnosis and treatment of neoplastic biliary lesions using a novel 9F and 11F digital single-operator cholangioscope Open
Background and study aims Digital single-operator cholangioscopy (DSOC) allows the diagnosis of biliary duct disorders and treatment for complicated stones. However, these technologies have limitations such as the size of the probe and wor…
View article: Risk Factors Associated with Mortality in Acinetobacter baumannii Infections: Results of a Prospective Cohort Study in a Tertiary Public Hospital in Guayaquil, Ecuador
Risk Factors Associated with Mortality in Acinetobacter baumannii Infections: Results of a Prospective Cohort Study in a Tertiary Public Hospital in Guayaquil, Ecuador Open
Antibiotic overuse and the resulting antimicrobial resistance pose significant global public health challenges, providing an avenue for opportunistic pathogens like Acinetobacter baumannii to thrive. This study will report the trends of Ac…
View article: Through-the-cholangioscope metal biliary stent placement as a novel endoscopic technique for bile duct strictures
Through-the-cholangioscope metal biliary stent placement as a novel endoscopic technique for bile duct strictures Open
The management of biliary strictures remains challenging. Biliary drainage via endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) are the currently preferred approaches [1] [2] [3], but advances in cholan…
View article: Epidural anesthesia for cesarean section with 0.125% versus 0.25% bupivacaine: an Ecuadorian prospective cohort
Epidural anesthesia for cesarean section with 0.125% versus 0.25% bupivacaine: an Ecuadorian prospective cohort Open
Background: In a cesarean section, epidural analgesia with 0.125% bupivacaine and 1.5% lidocaine or 0.25% bupivacaine with 1.0% lidocaine concentrations can be used.A higher concentration of bupivacaine reaches better analgesia but with a …
View article: Endoscopic Ultrasound-Guided Gallbladder Drainage Versus Percutaneous Drainage in Patients With Acute Cholecystitis Undergoing Elective Cholecystectomy
Endoscopic Ultrasound-Guided Gallbladder Drainage Versus Percutaneous Drainage in Patients With Acute Cholecystitis Undergoing Elective Cholecystectomy Open
INTRODUCTION: Cholecystectomy (CCY) is the gold standard treatment of acute cholecystitis (AC). Nonsurgical management of AC includes percutaneous transhepatic gallbladder drainage (PT-GBD) and endoscopic ultrasound-guided gallbladder drai…
View article: O-15 INFECTIONS BY MULTI-DRUG RESISTANT BACTERIA WERE INDEPENDENTLY ASSOCIATED WITH HOSPITAL MORTALITY IN CIRRHOTICS WITH ACUTE DECOMPENSATION: A PROSPECTIVE STUDY ON 433 ADMISSIONS
O-15 INFECTIONS BY MULTI-DRUG RESISTANT BACTERIA WERE INDEPENDENTLY ASSOCIATED WITH HOSPITAL MORTALITY IN CIRRHOTICS WITH ACUTE DECOMPENSATION: A PROSPECTIVE STUDY ON 433 ADMISSIONS Open
Introduction and Objectives: It has been described as bacterial infections (BIs) due to multidrug-resistant bacteria (MRB) in cirrhosis with acute decompensation (AD), with a potentially poor prognosis. This study aimed to determine the fr…
View article: Artificial intelligence for diagnosing neoplasia on digital cholangioscopy: development and multicenter validation of a convolutional neural network model
Artificial intelligence for diagnosing neoplasia on digital cholangioscopy: development and multicenter validation of a convolutional neural network model Open
Background We aimed to develop a convolutional neural network (CNN) model for detecting neoplastic lesions during real-time digital single-operator cholangioscopy (DSOC) and to clinically validate the model through comparisons with DSOC ex…
View article: Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population
Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population Open
Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population Carbapenémicos vs. ciprofloxacino/metronidazol…
View article: Endoscopic ultrasound elastography for malignant pancreatic masses and associated lymph nodes: Critical evaluation of strain ratio cutoff value
Endoscopic ultrasound elastography for malignant pancreatic masses and associated lymph nodes: Critical evaluation of strain ratio cutoff value Open
EUS elastography is a helpful technique for the diagnosis of solid PMs and their associated LNs. The proposed SR cutoff values have a high sensitivity and specificity for the detection of malignancy.
View article: Proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug-induced ulcers and dyspepsia
Proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug-induced ulcers and dyspepsia Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of proton pump inhibitors on the prevention of dyspepsia and ulcers in individuals with chronic consumption of non‐steroidal anti…
View article: Newly proposed quantitative criteria can assess chronic atrophic gastritis via probe-based confocal laser endomicroscopy (pCLE): a pilot study
Newly proposed quantitative criteria can assess chronic atrophic gastritis via probe-based confocal laser endomicroscopy (pCLE): a pilot study Open
Background and study aims Probe-based confocal laser endomicroscopy (pCLE) can provide high magnification to evaluate chronic atrophic gastritis (CAG), but the current pCLE criteria are qualitative and prone to variability. We aimed to pro…
View article: Cost-effectiveness of endoscopic ultrasound-guided coils plus cyanoacrylate injection compared to endoscopic cyanoacrylate injection in the management of gastric varices
Cost-effectiveness of endoscopic ultrasound-guided coils plus cyanoacrylate injection compared to endoscopic cyanoacrylate injection in the management of gastric varices Open
The use of EUS-guided coils plus cyanoacrylate is more cost-effective than cyanoacrylate injection when the total costs are evaluated. Larger, randomized trials are needed to validate the cost-effectiveness of the EUS-guided approach to tr…
View article: Results of liver and spleen endoscopic ultrasonographic elastography predict portal hypertension secondary to chronic liver disease
Results of liver and spleen endoscopic ultrasonographic elastography predict portal hypertension secondary to chronic liver disease Open
Background and study aims Assessment of endoscopic ultrasonography (EUS)-elastography of the liver and spleen may identify patients with portal hypertension secondary to chronic liver disease. We aimed to evaluate use of EUS-elastography o…