M. Teresa Magone
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View article: GZMK+CD8+ T cells target a specific acinar cell type in Sjögren's disease
GZMK+CD8+ T cells target a specific acinar cell type in Sjögren's disease Open
Using single-cell and spatial transcriptomics and proteomics, this study identifies a selective loss of PRR4⁺CST3⁺WFDC2⁻ seromucous acinar cells and a rise in GZMK⁺CD8⁺ T cells in Sjögren's disease, revealing distinct immune-mediated epith…
View article: Systemic Treatment with the Janus Kinase Inhibitor Baricitinib in Ocular Chronic Graft-versus-Host Disease
Systemic Treatment with the Janus Kinase Inhibitor Baricitinib in Ocular Chronic Graft-versus-Host Disease Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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View article: GZMK+CD8+ T cells Target A Specific Acinar Cell Type in Sjögren’s Disease
GZMK+CD8+ T cells Target A Specific Acinar Cell Type in Sjögren’s Disease Open
Sjögren's Disease (SjD) is a systemic autoimmune disease without a clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health and disease we developed a …
View article: Neuroimaging Findings in US Government Personnel and Their Family Members Involved in Anomalous Health Incidents
Neuroimaging Findings in US Government Personnel and Their Family Members Involved in Anomalous Health Incidents Open
Importance US government personnel stationed internationally have reported anomalous health incidents (AHIs), with some individuals experiencing persistent debilitating symptoms. Objective To assess the potential presence of magnetic reson…
View article: Clinical, Biomarker, and Research Tests Among US Government Personnel and Their Family Members Involved in Anomalous Health Incidents
Clinical, Biomarker, and Research Tests Among US Government Personnel and Their Family Members Involved in Anomalous Health Incidents Open
Importance Since 2015, US government and related personnel have reported dizziness, pain, visual problems, and cognitive dysfunction after experiencing intrusive sounds and head pressure. The US government has labeled these anomalous healt…
View article: GZMK+CD8+ T cells Target a Specific Acinar Cell Type in Sjögren’s Disease
GZMK+CD8+ T cells Target a Specific Acinar Cell Type in Sjögren’s Disease Open
Sjögren's Disease (SjD) is a systemic autoimmune disease without a clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health and disease we developed a …
View article: Evaluating Moisture Migration in Schirmer Test Strips: Exploring Brand-Specific Variations and Introducing Calibration and Conversion Methods
Evaluating Moisture Migration in Schirmer Test Strips: Exploring Brand-Specific Variations and Introducing Calibration and Conversion Methods Open
Purpose: Schirmer test results are widely used for ocular surface disease assessment, but Schirmer strips are not standardized. We compare the characteristics and tear volume with millimeter moisture migration in different brands of Schirm…
View article: Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren’s Disease
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren’s Disease Open
Objectives Inflammatory cytokines that signal through the JAK-STAT pathway, especially interferons (IFNs), are implicated in Sjögren’s Disease (SjD). Although inhibition of JAKs is effective in other autoimmune diseases, a systematic inves…
View article: Predictors and significance of kidney dysfunction in patients with chronic graft-versus-host disease
Predictors and significance of kidney dysfunction in patients with chronic graft-versus-host disease Open
View article: Ocular Findings of Cryptococcal Meningitis in Previously Healthy Adults
Ocular Findings of Cryptococcal Meningitis in Previously Healthy Adults Open
Background: Patients with cryptococcal meningitis (CM) often have ocular manifestations; although data are describing these findings in nonimmunosuppressed, previously healthy individuals are scarce. Methods: A retrospective chart review w…
View article: Infigratinib Reduces Fibroblast Growth Factor 23 ( <scp>FGF23)</scp> and Increases Blood Phosphate in <scp>Tumor‐Induced</scp> Osteomalacia
Infigratinib Reduces Fibroblast Growth Factor 23 ( <span>FGF23)</span> and Increases Blood Phosphate in <span>Tumor‐Induced</span> Osteomalacia Open
Tumor‐induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by ectopic production of fibroblast growth factor 23 (FGF23) by phosphaturic mesenchymal tumors (PMTs). Acting on renal tubule cells, excess FGF23 decreases phosphat…
View article: DeepLensNet: Deep Learning Automated Diagnosis and Quantitative Classification of Cataract Type and Severity
DeepLensNet: Deep Learning Automated Diagnosis and Quantitative Classification of Cataract Type and Severity Open
View article: Vulvovaginal and ocular involvement and treatment in female patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: A review
Vulvovaginal and ocular involvement and treatment in female patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: A review Open
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious adverse cutaneous drug reactions, characterized by epidermal detachment and mucous membrane involvement. SJS/TEN is more common in female patients, with unique…
View article: The sparkle in her eye: Crystal deposits in cornea, conjunctiva, meibombian glands, and iris in uncontrolled cystinosis
The sparkle in her eye: Crystal deposits in cornea, conjunctiva, meibombian glands, and iris in uncontrolled cystinosis Open
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View article: Outcomes in Previously Healthy Cryptococcal Meningoencephalitis Patients Treated With Pulse Taper Corticosteroids for Post-infectious Inflammatory Syndrome
Outcomes in Previously Healthy Cryptococcal Meningoencephalitis Patients Treated With Pulse Taper Corticosteroids for Post-infectious Inflammatory Syndrome Open
Background Cryptococcal meningoencephalitis (CM) is a major cause of mortality in immunosuppressed patients and previously healthy individuals. In the latter, a post-infectious inflammatory response syndrome (PIIRS) is associated with poor…
View article: Multimodal, multitask, multiattention (M3) deep learning detection of reticular pseudodrusen: Toward automated and accessible classification of age-related macular degeneration
Multimodal, multitask, multiattention (M3) deep learning detection of reticular pseudodrusen: Toward automated and accessible classification of age-related macular degeneration Open
Objective Reticular pseudodrusen (RPD), a key feature of age-related macular degeneration (AMD), are poorly detected by human experts on standard color fundus photography (CFP) and typically require advanced imaging modalities such as fund…
View article: Multi-modal, multi-task, multi-attention (M3) deep learning detection of reticular pseudodrusen: towards automated and accessible classification of age-related macular degeneration
Multi-modal, multi-task, multi-attention (M3) deep learning detection of reticular pseudodrusen: towards automated and accessible classification of age-related macular degeneration Open
Objective Reticular pseudodrusen (RPD), a key feature of age-related macular degeneration (AMD), are poorly detected by human experts on standard color fundus photography (CFP) and typically require advanced imaging modalities such as fund…
View article: Ocular Adverse Effects of Infigratinib, a New Fibroblast Growth Factor Receptor Tyrosine Kinase Inhibitor
Ocular Adverse Effects of Infigratinib, a New Fibroblast Growth Factor Receptor Tyrosine Kinase Inhibitor Open
View article: Surgical simulator training reduces operative times in resident surgeons learning phacoemulsification cataract surgery
Surgical simulator training reduces operative times in resident surgeons learning phacoemulsification cataract surgery Open
Early and continuous implementation of mandatory virtual simulator surgical training before starting intraocular surgeries significantly decreases operative times in third year residents learning phacoemulsification compared to non-simulat…
View article: Long-Term Outcomes of Refractive Surgery Performed During the Military
Long-Term Outcomes of Refractive Surgery Performed During the Military Open
Introduction To evaluate the long-term refractive results of laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) performed by the military in a veteran population. Materials and Methods Three Department of Veterans A…
View article: Ocular Adverse Events following Use of Immune Checkpoint Inhibitors for Metastatic Malignancies
Ocular Adverse Events following Use of Immune Checkpoint Inhibitors for Metastatic Malignancies Open
We found a wide spectrum of ocular irAEs associated with immune checkpoint inhibitors. In most cases, ocular AEs did not limit ongoing cancer treatment.
View article: Eleven Years of Cataract Surgery in Veterans Without Pre-existing Ocular Comorbidities
Eleven Years of Cataract Surgery in Veterans Without Pre-existing Ocular Comorbidities Open
Introduction In 2017, over 75,000 cataract surgeries were performed within the Veterans Health Administration System (VHA). Previous reports of outcomes of cataract surgery in veterans include patients with pre-existing ocular disease, whi…