Explanipedia

C-reactive protein-to-albumin ratio as a Novel Prognostic Biomarker for Long-Term Mortality in Pericarditis: A Real-World Study Open

Ishan Lakhani, Gary M. Tse · 2025

Background Pericarditis is a heterogeneous inflammatory condition with variable clinical outcomes. Although traditional inflammatory biomarkers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are routinely used fo…

Antibody–drug conjugates in cancer therapy: current landscape, challenges, and future directions Open

Bonan Chen, Xiaohong Zheng, Jialin Wu, Guoming Chen, Jun Yu , et al. · 2025

Antibody-drug conjugates (ADCs) have emerged as a transformative modality in oncology by combining the target specificity of antibodies with the high potency of diverse cytotoxic payloads. This review provides an integrative overview of AD…

Evaluating human-in-the-loop strategies for artificial intelligence-enabled translation of patient discharge instructions: a multidisciplinary analysis Open

Ryan Brewster, Gary M. Tse, Angela L. Fan, Marwa Elborki, Martin E. Newell , et al. · 2025

TET2 mutations in myeloproliferative neoplasms: potential mediation of atrial fibrillation by interleukin-1β and impact on stroke risk in clinical cohorts Open

Guangshuai Teng, Minghui Duan, Ke Shang, Yuhui Zhang, Xiaojing Wei , et al. · 2025

TET2 mutations increase the risk of AF, which may be associated with the IL-1β-mediated inflammatory pathway. AF serves as a critical intermediary for CHIP-associated ischemic stroke. Integrating TET2 status into AF surveillance and antico…

Effects of exergaming with a resistance component versus traditional resistance training on sarcopenia in pre-frail and frail nursing home residents: a pilot randomized controlled trial Open

Tai Wa Liu, Bonny Yee-Man Wong, Timothy T.T. Yam, William W.N. Tsang, Gary M. Tse , et al. · 2025

Purpose To compare exergaming with a resistance component and traditional resistance training in terms of feasibility and the preliminary effects on sarcopenia, cognition, functional mobility, and frailty among pre-frail and frail nursing …

Artificial intelligence-enabled single-lead electrocardiogram in early detection of ischemic heart disease Open

Won-Chang Song, Gary M. Tse, Kang‐Yin Chen · 2025

With the rapid advancement and widespread adoption of new artificial intelligence (AI) technologies, personalized medicine and more accurate diagnosis using medical imaging are now possible. Among its many applications, AI has shown remark…

Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism Open

Wing-Cheung Chan, Qian Zhao, Koon Ho Wong, Hok-Him Tang, Daniel Kam‐Wah Mok , et al. · 2025

Tetrandrine (Tet) is a potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable photoaffinity probe, …

Indobufen versus aspirin after percutaneous coronary intervention in elderly patients with acute coronary syndrome Open

Wenbo Dai, Guanyu Mu, Jiayi Ren, Sutao Hu, Rongxin Guo , et al. · 2025

Differential effects of glucagon-like peptide-1 receptor agonist classes on blood pressure: a systematic review and network meta-analysis of randomised controlled trials with meta-regression Open

Oscar Hou In Chou, Haixin Zhou, Hamza Waraich, Derek Wu, Keanu Razzaghi , et al. · 2025

Background and Aims: Recent clinical trials have reported blood pressure (BP)-lowering effects of glucagon-like peptide-1 receptor agonists (GLP1Ra). A recent systematic review has focused on the effects of semaglutide. However, there has …

Comparative Effectiveness of Mechanical Circulatory Support Devices in Patients Undergoing Complex High‐Risk Percutaneous Coronary Interventions (CHIP): A Systematic Review and Network Meta‐Analysis Open

Haonan Xu, Wenxin Guo, Oscar Hou In Chou, Gary M. Tse, Guangping Li , et al. · 2025

Background Patients undergoing complex high‐risk percutaneous coronary interventions (CHIP) are prone to hemodynamic instability, and the optimal mechanical circulatory support (MCS) strategy for this population remains unclear. Aims This …

Polypharmacy and multimorbidity metrics for predicting ischaemic stroke using machine learning: The Hong Kong Diabetes Study Open

Gary M. Tse, C T Yang, Seung Eun Lee, Han‐Pin Pui, B K H Leung , et al. · 2025

Background and Objective Diabetes mellitus is associated with a two- to five-fold increase in the risk of ischaemic stroke. The purpose of this study is to study whether identify individuals at risk of stroke among the diabetic population …

Biodyn: web-based real-time dynamic biological age calculator Open

Gary M. Tse, Ana Aranda, M Beni, Hao Liu, Quinncy Lee , et al. · 2025

Background and Objectives The accuracy of biological age (BA) calculations is highly influenced by the data used in each estimation. Expanding the data pool and efficiently integrating new data to refine the regression models for BA estima…

Multiparametric models based on variability in lipid tests and pro-inflammatory biomarkers for atrial fibrillation and stroke prediction: The Hong Kong Family Medicine Study Open

Gary M. Tse, Ching-Lung Chang, Oscar Hou In Chou, Quinncy Lee, C T Chung , et al. · 2025

Objective The objective of this study was to investigate possible associations between measures of variability in lipid tests for atrial fibrillation and stroke prediction, and develop predictive models incorporating these metrics. Methods…

Malignant phyllodes tumours of the breast: the case for revising <span>WHO’</span>s ‘full house’ diagnostic criteria Open

Puay Hoon Tan, Ian O. Ellis, Kimberly H. Allison, Sunil Badve, Edi Brogi , et al. · 2025

Phyllodes tumours (PTs) of the breast present diagnostic challenges due to their complex histological features and potential for malignant behaviour. The World Health Organisation (WHO) classification requires the presence of five adverse …

Classification of Fibroepithelial Lesions of the Breast in Core Needle Biopsy With Implications for Further Management Open

Emad A. Rakha, Cecily Quinn, Wendy A. Raymond, Kimberly H. Allison, Sunil Badve , et al. · 2025

Overcoming immunotherapy resistance in hepatocellular carcinoma by targeting myeloid IL-8/CXCR2 signaling Open

Tsz Tung Kwong, Zhewen Xiong, Yiling Zhang, Haoran Wu, Jian Cao , et al. · 2025

Bleeding as a Sentinel Event in New Malignancy Diagnoses Across Diverse Indications for Oral Anticoagulant Use: A Real-World Cohort, Nested Case-Control and Target Trial Emulation Study Open

Zuo Qi, Junyu Liu, Tianshu Gu, Ning Wu, Jinhua Zhao , et al. · 2025

Clinical Application of Artificial Intelligence in the Diagnosis, Prediction, and Classification of Coronary Heart Disease Open

Mahbuba Ferdowsi, Choon‐Hian Goh, Haipeng Liu, Gary M. Tse, Jeremy Man Ho Hui , et al. · 2025

Coronary heart disease (CHD), the most common cause of mortality globally, poses a formidable challenge to modern healthcare systems. Artificial intelligence (AI) is playing an increasingly important role in multiple diagnostic application…

Early Risk Detection of Atherosclerotic Cardiovascular Diseases in Patients with Type 2 Diabetes Using Multi-Label Machine Learning: A Chinese Cohort Study Open

Zeneng Cheng, Lei Lü, Nan Zhang, Hou In Chou, Tong Liu , et al. · 2025

Diagnostic performance of a point-of-care high-sensitivity cardiac troponin I assay among Chinese patients with chest pain Open

Jonathan Ka-Ming Ho, Janet Yuen Ha Wong, Gary M. Tse, A. Chong, Charlene Yat Che Chau , et al. · 2024

Background A novel handheld point-of-care high-sensitivity cardiac troponin I analyser has recently been introduced to the market. Evaluating its diagnostic performance against laboratory standards is imperative, given the variations in ca…

Feasibility of Self-Expanding Transcatheter Pulmonary Valves in Patients with Pyramidal RVOT: Favorable Mid-term Outcomes Open

Wenhao Zhu, Zhiyuan Xia, Joe Kai, Junyi Wan, Liang Xu , et al. · 2024

Background Transcatheter pulmonary valve replacement (TPVR) has been acknowledged as a common and beneficial treatment for significant pulmonary regurgitation (PR), but data are still lacking about the mid-term effects of self-expanding va…

Clinical values of nuclear morphometric analysis in fibroepithelial lesions Open

Conrad Lee, HC Yip, Joshua Li, Joanna Ng, Julia Y. Tsang , et al. · 2024

Background Fibroepithelial lesions (FELs) of the breast encompass a broad spectrum of lesions, ranging from commonly encountered fibroadenomas (FAs) to rare phyllodes tumors (PTs). Accurately diagnosing and grading these lesions is crucial…

Figure S13 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open