M V Chandrakanth
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View article: Practice Patterns and Outcomes in Advanced Colorectal Cancers From a Multi-Institutional Analysis: Real-World Evidence From India
Practice Patterns and Outcomes in Advanced Colorectal Cancers From a Multi-Institutional Analysis: Real-World Evidence From India Open
PURPOSE There are limited data on presentation and practice patterns, survival, and factors influencing overall survival (OS) in Indian patients with metastatic colorectal cancers (mCRCs). PATIENTS AND METHODS The current study evaluated p…
View article: Evolving Treatment Paradigms in Metastatic Hormone-Sensitive Prostate Cancer: Expert Narrative Review
Evolving Treatment Paradigms in Metastatic Hormone-Sensitive Prostate Cancer: Expert Narrative Review Open
The treatment landscape of metastatic hormone-sensitive prostate cancer (mHSPC) has transformed significantly with the advent of triplet therapy involving androgen deprivation therapy (ADT), docetaxel, and androgen receptor signalling inhi…
View article: Weekly paclitaxel, carboplatin and cetuximab (PCC) combination followed by nivolumab in platinum-sensitive recurrent and /or metastatic squamous cell carcinoma of head and neck: a retrospective analysis from two institutions in India
Weekly paclitaxel, carboplatin and cetuximab (PCC) combination followed by nivolumab in platinum-sensitive recurrent and /or metastatic squamous cell carcinoma of head and neck: a retrospective analysis from two institutions in India Open
Background First line (1L) TP-Ex-like regimen followed by 2nd-line (2L) immunotherapy represents one of the standards of care in platinum-sensitive recurrent and/or metastatic squamous cell carcinoma of head and neck (R/M SCCHN). We report…
View article: Cresp®: transforming the landscape of chemotherapy-induced anemia - a comprehensive retrospective real-world analysis in 523 Indian patients
Cresp®: transforming the landscape of chemotherapy-induced anemia - a comprehensive retrospective real-world analysis in 523 Indian patients Open
Introduction Anemia, a frequently encountered issue among cancer patients undergoing chemotherapy, is regrettably underappreciated despite its prevalence and profound impact on their well-being. Chemotherapy-induced anemia (CIA) diminishes…
View article: Context-dependent effects of developmental and adult diet on life-history traits in <i>Drosophila melanogaster</i>
Context-dependent effects of developmental and adult diet on life-history traits in <i>Drosophila melanogaster</i> Open
Life-history traits such as body size, reproduction, survival, and stress resistance are fundamental to an organism’s fitness and are highly influenced by nutritional environments across life stages. In this study, we employed a full facto…
View article: Weekly paclitaxel, carboplatin and cetuximab (PCC) combination followed by nivolumab in platinum-sensitive recurrent and /or metastatic squamous cell carcinoma of head and neck: a retrospective analysis from two institutions in India
Weekly paclitaxel, carboplatin and cetuximab (PCC) combination followed by nivolumab in platinum-sensitive recurrent and /or metastatic squamous cell carcinoma of head and neck: a retrospective analysis from two institutions in India Open
Background: First line (1L) TP-Ex-like regimen followed by 2nd-line (2L) immunotherapy represents one of the standards of care in platinum-sensitive recurrent and/or metastatic squamous cell carcinoma of head and neck (R/M SCCHN). We repo…
View article: Effect of developmental and adult diet composition on reproductive aging in<i>Drosophila melanogaster</i>
Effect of developmental and adult diet composition on reproductive aging in<i>Drosophila melanogaster</i> Open
Diet significantly affects reproductive outcomes across species, yet the precise effects of macronutrient compositions beyond caloric intake on reproductive aging are understudied. Existing literature presents conflicting views on the fert…
View article: Diet‐induced plasticity of life‐history traits and gene expression in outbred <i>Drosophila melanogaster</i> population
Diet‐induced plasticity of life‐history traits and gene expression in outbred <i>Drosophila melanogaster</i> population Open
Food is fundamental for the survival of organisms, governing growth, maintenance, and reproduction through the provision of essential macronutrients. However, access to food with optimum macronutrient composition, which will maximize the e…
View article: A Comparative Study Evaluating the Quality of Life and Survival Outcomes in Patients Receiving Chemotherapy Versus Oral Tyrosine Kinase Inhibitor in the Third Line and Beyond Setting for Advanced NSCLC
A Comparative Study Evaluating the Quality of Life and Survival Outcomes in Patients Receiving Chemotherapy Versus Oral Tyrosine Kinase Inhibitor in the Third Line and Beyond Setting for Advanced NSCLC Open
There was no significant difference in most QoL scales (except cognitive function and alopecia), OS, and PFS of patients with advanced NSCLC receiving an EGFR TKI as compared with chemotherapy TKI in the third-line setting. The toxicity pr…
View article: Diet-induced plasticity of life-history traits and gene expression in outbred<i>Drosophila melanogaster</i>population
Diet-induced plasticity of life-history traits and gene expression in outbred<i>Drosophila melanogaster</i>population Open
Food is fundamental for the survival of organisms, governing growth, maintenance, and reproduction through the provision of essential macronutrients. However, access to food with optimum macronutrient composition, which will maximize the e…
View article: Weekly paclitaxel, carboplatin and cetuximab (PCC) combination followed by nivolumab in platinum-sensitive recurrent and /or metastatic squamous cell carcinoma of head and neck: a retrospective analysis from two institutions in India
Weekly paclitaxel, carboplatin and cetuximab (PCC) combination followed by nivolumab in platinum-sensitive recurrent and /or metastatic squamous cell carcinoma of head and neck: a retrospective analysis from two institutions in India Open
Background: First line (1L) TP-Ex-like regimen followed by 2nd-line (2L) immunotherapy represents one of the standards of care in platinum-sensitive recurrent and/or metastatic squamous cell carcinoma of head and neck (R/M SCCHN). We repo…
View article: TP Ex for analysis- Weekly paclitaxel baseline data- Revised.xlsx
TP Ex for analysis- Weekly paclitaxel baseline data- Revised.xlsx Open
Baseline data of Weekly paclitaxel, carboplatin and cetuximab (PCC) combination followed by nivolumab in platinum-sensitive recurrent and /or metastatic squamous cell carcinoma of head and neck– a retrospective analysis from two institutio…
View article: TP Ex for analysis- Weekly paclitaxel baseline data- revision 2.xlsx
TP Ex for analysis- Weekly paclitaxel baseline data- revision 2.xlsx Open
It consists of baseline data wich includes parameters like, PFI, local, brain, liver, bone, lung, skin, muscle, Hypertension, renal. Please consider vaseline data revision 2 as latest sheet.
View article: Quality of life and quality-adjusted time without toxicity in palliatively treated head-and-neck cancer patients
Quality of life and quality-adjusted time without toxicity in palliatively treated head-and-neck cancer patients Open
Background: Quality-adjusted time without toxicity (Q-TWiST) and quality of life (QOL) are indicators of benefit provided by different chemotherapy regimens. Methods: This was a prospective study, in which adult head-and-neck (H and N) can…
View article: Shadow study: randomized comparison of clinic with video follow-up in glioma undergoing adjuvant temozolomide therapy
Shadow study: randomized comparison of clinic with video follow-up in glioma undergoing adjuvant temozolomide therapy Open
VF can substitute CF during adjuvant TMZ administration (CTRI/2017/01/007626).
View article: EMERALD: Emergency visit audit of patients treated under medical oncology in a tertiary cancer center: Logical steps to decrease the burden
EMERALD: Emergency visit audit of patients treated under medical oncology in a tertiary cancer center: Logical steps to decrease the burden Open
Background: We are a tertiary care cancer center and have approximately 1000–1500 emergency visits by cancer patients undergoing treatment under the adult medical oncology unit each month. However, due to the lack of a systematic audit, we…
View article: OUTCOMES OF TREATMENT OF UNRESECTABLE ESOPHAGEAL CARCINOMA TREATED WITH CHEMORADIOTHERAPY AND ORAL METRONOMIC CHEMOTHERAPY: AN EXPERIENCE FROM A RURAL CANCER CENTER
OUTCOMES OF TREATMENT OF UNRESECTABLE ESOPHAGEAL CARCINOMA TREATED WITH CHEMORADIOTHERAPY AND ORAL METRONOMIC CHEMOTHERAPY: AN EXPERIENCE FROM A RURAL CANCER CENTER Open
Introduction: Esophageal carcinoma is the eight most common cancer in the world. The management of locally advancedcarcinoma esophagus is mainly palliative with chemoradiotherapy. The outcome data of such a modality along with oralmetronom…