Eliana Vásquez Osorio
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View article: Data from Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy
Data from Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy Open
Purpose:Genome-wide association studies are the gold standard for identifying SNP associated with rectal toxicity after prostate cancer radiotherapy. However, they often neglect the radiotherapy dose distribution, which is a key contributo…
View article: Clinical evidence and reporting standards in reirradiation: Insights from 28 studies at ESTRO 2025, endorsed by the ESTRO reirradiation focus group
Clinical evidence and reporting standards in reirradiation: Insights from 28 studies at ESTRO 2025, endorsed by the ESTRO reirradiation focus group Open
View article: Cumulative dose evaluation in clinical reirradiation – Consensus guidance on technical considerations by the ESTRO reirradiation focus group
Cumulative dose evaluation in clinical reirradiation – Consensus guidance on technical considerations by the ESTRO reirradiation focus group Open
Reirradiation is increasingly used, but its safe application requires accurate evaluation of cumulative doses to organs at risk. Methods of cumulative dose evaluation vary widely, from simple summation of prescription doses to complex thre…
View article: The concept of virtual clinical trials: A game changer in radiation oncology research?
The concept of virtual clinical trials: A game changer in radiation oncology research? Open
Virtual clinical trials use computer simulations (e.g. radiation physics and radiobiology) and/or real-world data (e.g. patient anatomy and tissue characteristics) to model radiation oncology treatments, addressing limitations of tradition…
View article: Associations between patient-reported neurocognition, mood, and fatigue and radiation dose in oropharyngeal cancer survivors
Associations between patient-reported neurocognition, mood, and fatigue and radiation dose in oropharyngeal cancer survivors Open
There are potential positive associations between right-posterior cerebellum dose with late mood disturbance and fatigue, including potential dose-effect thresholds and cerebella sensitivity to dose per fraction. Further research is needed…
View article: Towards Gaussian processes modelling to study the late effects of radiotherapy in children and young adults with brain tumours
Towards Gaussian processes modelling to study the late effects of radiotherapy in children and young adults with brain tumours Open
Survivors of childhood cancer need lifelong monitoring for side effects from radiotherapy. However, longitudinal data from routine monitoring is often infrequently and irregularly sampled, and subject to inaccuracies. Due to this, measurem…
View article: Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy
Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy Open
Purpose: Genome-wide association studies are the gold standard for identifying SNP associated with rectal toxicity after prostate cancer radiotherapy. However, they often neglect the radiotherapy dose distribution, which is a key contribut…
View article: Sensitivity analysis of dose-response model parameters for the bladder in prostate cancer radiotherapy
Sensitivity analysis of dose-response model parameters for the bladder in prostate cancer radiotherapy Open
Parameter selection significantly influences high-risk subregion identification in DRMs, emphasizing the need for standardized parameter reporting for meaningful external comparisons.
View article: Individualised dose mapping uncertainty estimation in the reirradiation setting
Individualised dose mapping uncertainty estimation in the reirradiation setting Open
View article: Dose Mapping Using Image Registration for Reirradiation: A Systematic Review
Dose Mapping Using Image Registration for Reirradiation: A Systematic Review Open
As reirradiation becomes increasingly common due to longer patient survival, accurately mapping previous radiation dose is essential to balance toxicity and tumour control. Image registration (IR) is widely used to align previous dose dist…
View article: External validation of deep learning-derived 18F-FDG PET/CT delta biomarkers for loco-regional control in head and neck cancer
External validation of deep learning-derived 18F-FDG PET/CT delta biomarkers for loco-regional control in head and neck cancer Open
Background and purpose: Delta biomarkers that reflect changes in tumour burden over time can support personalised follow-up in head and neck cancer. However, their clinical use can be limited by the need for manual image segmentation. This…
View article: Radiation exposure of breast tissue in lymphoma radiotherapy: a systematic review of breast dose metrics published since 2000
Radiation exposure of breast tissue in lymphoma radiotherapy: a systematic review of breast dose metrics published since 2000 Open
Background and purpose: We present a systematic review of breast dose metrics reported in lymphoma patients receiving radiotherapy and provide reporting recommendations for breast dose in future publications. Methods and materials: Studies…
View article: Clinical workflow for reirradiation: national consensus recommendations on imaging, treatment planning, dose accumulation, and treatment delivery
Clinical workflow for reirradiation: national consensus recommendations on imaging, treatment planning, dose accumulation, and treatment delivery Open
Background and purpose: Reirradiation is becoming more frequent in clinical practice. However, workflows and practices vary widely between clinics, as general guidelines are scarce or lacking in practical detail. This paper presents compre…
View article: Dose-response mapping of bladder and rectum in prostate cancer patients undergoing radiotherapy with and without baseline toxicity correction
Dose-response mapping of bladder and rectum in prostate cancer patients undergoing radiotherapy with and without baseline toxicity correction Open
DRM without baseline correction appears more sensitive to high-risk subregions due to higher event counts. Non-linear toxicity grading and multivariable analysis may enhance DRM reliability.
View article: Methods of causal effect estimation for high‐dimensional treatments: A radiotherapy simulation study
Methods of causal effect estimation for high‐dimensional treatments: A radiotherapy simulation study Open
Background Radiotherapy, the use of high‐energy radiation to treat cancer, presents a challenge in determining treatment outcome relationships due to its complex nature. These challenges include its continuous, spatial, high‐dimensional, m…
View article: Reirradiation: Standards, challenges, and patient‐focused strategies across tumor types
Reirradiation: Standards, challenges, and patient‐focused strategies across tumor types Open
Reirradiation (reRT), defined as administering a course of radiation therapy to a specific area previously irradiated, is an evolving treatment strategy for locoregionally recurrent cancer that offers significant potential and poses inhere…
View article: Data, dialogue, and design: patient and public involvement and engagement for natural language processing with real-world cancer data
Data, dialogue, and design: patient and public involvement and engagement for natural language processing with real-world cancer data Open
Introduction This study describes the process and outcomes of a Patient and Public Involvement and Engagement (PPIE) event designed to incorporate patient perspectives into the application of Natural Language Processing (NLP) for analyzing…
View article: The value of post radiotherapy prostate specific antigen dynamics for prostate cancer risk stratification models
The value of post radiotherapy prostate specific antigen dynamics for prostate cancer risk stratification models Open
View article: An anatomically-informed correspondence initialisation method to improve learning-based registration for radiotherapy
An anatomically-informed correspondence initialisation method to improve learning-based registration for radiotherapy Open
We propose an anatomically-informed initialisation method for interpatient CT non-rigid registration (NRR), using a learning-based model to estimate correspondences between organ structures. A thin plate spline (TPS) deformation, set up us…
View article: Towards Automatic Identification of Missing Tissues using a Geometric-Learning Correspondence Model
Towards Automatic Identification of Missing Tissues using a Geometric-Learning Correspondence Model Open
Missing tissue presents a big challenge for dose mapping, e.g., in the reirradiation setting. We propose a pipeline to identify missing tissue on intra-patient structure meshes using a previously trained geometric-learning correspondence m…
View article: Hepatoprotective effect of the Sechium HD-Victor hybrid extract in a model of liver damage induced by carbon tetrachloride in mice
Hepatoprotective effect of the Sechium HD-Victor hybrid extract in a model of liver damage induced by carbon tetrachloride in mice Open
Sechium spp., is a vegetable species renowned for its pharmacological properties, including hepatoprotective activity. This species can crossbreed with its wild relatives, leading to the creation of an HD-Victor hybrid with higher levels o…
View article: Dose-Response Mapping of Bladder and Rectum in Prostate Cancer Patients Undergoing Radiotherapy with and Without Baseline Toxicity Normalization
Dose-Response Mapping of Bladder and Rectum in Prostate Cancer Patients Undergoing Radiotherapy with and Without Baseline Toxicity Normalization Open
View article: Dose-Response Mapping of Bladder and Rectum in Prostate Cancer Patients Undergoing Radiotherapy with and Without Baseline Toxicity Correction
Dose-Response Mapping of Bladder and Rectum in Prostate Cancer Patients Undergoing Radiotherapy with and Without Baseline Toxicity Correction Open
View article: New rectum dose surface mapping methodology to identify rectal subregions associated with toxicities following prostate cancer radiotherapy
New rectum dose surface mapping methodology to identify rectal subregions associated with toxicities following prostate cancer radiotherapy Open
We developed a methodology that unfolds the rectum to a 2D surface map. The lower posterior was significant for clinician-reported proctitis and patient-reported bowel urgency, suggesting that reducing the dose in the region could decrease…
View article: Individualised Dose Mapping Uncertainty Estimation in the Reirradiation Setting
Individualised Dose Mapping Uncertainty Estimation in the Reirradiation Setting Open
View article: A neural network to create super‐resolution MR from multiple 2D brain scans of pediatric patients
A neural network to create super‐resolution MR from multiple 2D brain scans of pediatric patients Open
Background High‐resolution (HR) 3D MR images provide detailed soft‐tissue information that is useful in assessing long‐term side‐effects after treatment in childhood cancer survivors, such as morphological changes in brain structures. Howe…
View article: The clinical application of in vivo dosimetry for gynaecological brachytherapy: A scoping review
The clinical application of in vivo dosimetry for gynaecological brachytherapy: A scoping review Open
View article: Ongoing prospective studies on reirradiation: A systematic review of a clinical trials database
Ongoing prospective studies on reirradiation: A systematic review of a clinical trials database Open
View article: Optimising inter-patient image registration for image-based data mining in breast radiotherapy
Optimising inter-patient image registration for image-based data mining in breast radiotherapy Open
B-spline algorithm using NMI and registered supine and prone cohorts independently provides the most optimal spatial normalisation strategy for breast IBDM.
View article: CT- and MR-based image-based data mining are consistent in the brain
CT- and MR-based image-based data mining are consistent in the brain Open
CT-based IBDM was comparable to MR-based IBDM, despite a small advantage in spatial normalisation accuracy with MRI. The use of CT-IBDM over MR-IBDM is useful for multi-institutional retrospective IBDM studies, where the availability of st…