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View article: Impact of Delayed Cord Clamping and Immediate Kangaroo Mother Care on Oxygen Saturation and Heart Rate in Moderate and Late Preterm Infants
Impact of Delayed Cord Clamping and Immediate Kangaroo Mother Care on Oxygen Saturation and Heart Rate in Moderate and Late Preterm Infants Open
Background: Immediate Kangaroo Mother Care (iKMC) after delivery and delayed cord clamping (DCC), both improve cardiorespiratory stability in newborns. Methods: This prospective observational study included 96 moderate to late preterm (MLP…
View article: A phase 1b randomized, multicenter, dose determination trial of zelpultide alfa (recombinant human surfactant protein D) in preterm neonates at high risk of developing bronchopulmonary dysplasia
A phase 1b randomized, multicenter, dose determination trial of zelpultide alfa (recombinant human surfactant protein D) in preterm neonates at high risk of developing bronchopulmonary dysplasia Open
Background Bronchopulmonary dysplasia (BPD) ranks among the most severe long-term complications of prematurity. Surfactant protein D, not present in commercial surfactant, regulates the innate immune response of the lungs by clearing infec…
View article: International Variation and Trends of Intraventricular Hemorrhage in Very Preterm Infants
International Variation and Trends of Intraventricular Hemorrhage in Very Preterm Infants Open
Introduction: We aimed to investigate international variation in gestational age (GA) specific severe intraventricular hemorrhage (IVH) rates, among infants of
View article: Transfusion Practices in 12 Neonatal Networks: Are We Closer to Adopting a Restrictive Transfusion Approach?
Transfusion Practices in 12 Neonatal Networks: Are We Closer to Adopting a Restrictive Transfusion Approach? Open
Introduction: Recent evidence suggests a restrictive approach toward blood transfusions for management of preterm infants. Objective was to survey blood transfusion practises in preterm neonates ≤35% in 79% of NICUs, and at an age ≥8 days,…
View article: Biomarkers of oxidative stress and inflammation in urine samples of extremely preterm newborns and risk for autism at corrected-age 24 months
Biomarkers of oxidative stress and inflammation in urine samples of extremely preterm newborns and risk for autism at corrected-age 24 months Open
Introduction Extremely preterm birth (defined as birth before 28 weeks’ gestational age) has been associated with an increased risk of developing autism spectrum disorder (ASD) in infancy. The underlying pathophysiological mechanisms drivi…
View article: Delivery Room Handling of the Newborn: Filling the Gaps
Delivery Room Handling of the Newborn: Filling the Gaps Open
Background: Newborn resuscitation algorithms have since the turn of the century been more evidence-based. In this review, we discuss the development of American Heart Association (AHA) and the International Liaison Committee on Resuscitati…
View article: Initial Oxygen Concentration for the Resuscitation of Infants Born at Less Than 32 Weeks’ Gestation
Initial Oxygen Concentration for the Resuscitation of Infants Born at Less Than 32 Weeks’ Gestation Open
Importance Resuscitation with lower fractional inspired oxygen (FiO 2 ) reduces mortality in term and near-term infants but the impact of this practice on very preterm infants is unclear. Objective To evaluate the relative effectiveness of…
View article: Meeting the need for effective and standardized neonatology training: a pan-European Master’s Curriculum
Meeting the need for effective and standardized neonatology training: a pan-European Master’s Curriculum Open
Neonatology is a pediatric sub-discipline focused on providing care for newborn infants, including healthy newborns, those born prematurely, and those who present with illnesses or malformations requiring medical care. The European Trainin…
View article: Does the use of higher versus lower oxygen concentration improve neurodevelopmental outcomes at 18–24 months in very low birthweight infants?
Does the use of higher versus lower oxygen concentration improve neurodevelopmental outcomes at 18–24 months in very low birthweight infants? Open
Background Immediately after birth, the oxygen saturation is between 30 and 50%, which then increases to 85–95% within the first 10 min. Over the last 10 years, recommendations regarding the ideal level of the initial fraction of inspired …
View article: Repeated intravenous doses of human umbilical cord-derived mesenchymal stromal cells for bronchopulmonary dysplasia: results of a phase 1 clinical trial with 2-year follow-up
Repeated intravenous doses of human umbilical cord-derived mesenchymal stromal cells for bronchopulmonary dysplasia: results of a phase 1 clinical trial with 2-year follow-up Open
The administration of repeated intravenous infusion of UC-MSCs in ELGANs at a high risk of developing BPD was feasible and safe in the short- and mid-term follow-up.
View article: Supplementary Material for: International online survey on the management of patent ductus arteriosus
Supplementary Material for: International online survey on the management of patent ductus arteriosus Open
Introduction There is uncertainty and lack of consensus regarding optimal management of patent ductus arteriosus (PDA). We aimed to determine current clinical practice in PDA management across a range of different regions internationally. …
View article: European Training Requirements in Neonatology 2021: The ESPR, EAP, and UEMS Accredited European Syllabus for Neonatal Training
European Training Requirements in Neonatology 2021: The ESPR, EAP, and UEMS Accredited European Syllabus for Neonatal Training Open
Introduction: The European Union stipulates transnational recognition of professional qualifications for several sectoral professions, including medical doctors. The Union of European Medical Specialists (UEMS), in its “Charter on Training…
View article: Effect of autologous umbilical cord blood transfusion in the development of retinopathy of prematurity: randomized clinical trial – study protocol
Effect of autologous umbilical cord blood transfusion in the development of retinopathy of prematurity: randomized clinical trial – study protocol Open
Background Currently, the treatment of anemia in preterm infants is based on packed red blood cell (RBC) transfusions from adult donors. Oxygen (O2) is mainly transported to the tissues bound to hemoglobin (Hb). In extremely low gestationa…
View article: Clinical Parameters in the First 5 Minutes after Birth Have a Predictive Value for Survival of Extremely Preterm Infants
Clinical Parameters in the First 5 Minutes after Birth Have a Predictive Value for Survival of Extremely Preterm Infants Open
Extreme preterm infants (60%) and lower (<30%) initial FiO 2 . Recent evidence and meta-analyses have underscored the predictive value for survival and/or relevant clinical outcomes of the Apgar score and the achievement of arterial oxygen…
View article: Psychomotor development, emotional regulation, and executive functions in 2-years-old children after a threatened preterm labour: a prospective study
Psychomotor development, emotional regulation, and executive functions in 2-years-old children after a threatened preterm labour: a prospective study Open
Objective A threatened preterm labour (TPL) represents an adverse prenatal event with potential long-term consequences on offspring’ neurodevelopment, regardless of prematurity condition. The aim of this study was to assess TPL impact on c…