M. Viguier
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View article: Comprehensive Literature Review Evaluating the Use, Safety, and Efficacy of Subcutaneous Methotrexate in the Treatment of Adult Patients With Moderate‐To‐Severe Plaque‐Type Psoriasis
Comprehensive Literature Review Evaluating the Use, Safety, and Efficacy of Subcutaneous Methotrexate in the Treatment of Adult Patients With Moderate‐To‐Severe Plaque‐Type Psoriasis Open
Methotrexate (MTX) is a conventional systemic therapy widely used to treat chronic plaque‐type psoriasis, a chronic inflammatory skin disease that significantly impacts patients' quality of life. MTX can be administered orally or subcutane…
View article: Impact of autoantibody status on stratifying the risk of organ involvement and mortality in SSc: experience from a multicentre French cohort of 1605 patients
Impact of autoantibody status on stratifying the risk of organ involvement and mortality in SSc: experience from a multicentre French cohort of 1605 patients Open
Introduction Systemic sclerosis (SSc) is a rare autoimmune disease currently classified into two subgroups based on skin extension. The aim of this study was to determine in a large cohort whether the determination of autoantibody (AAb) pr…
View article: Polarization of circulating follicular helper T cells correlates with bullous pemphigoid severity
Polarization of circulating follicular helper T cells correlates with bullous pemphigoid severity Open
Background Follicular helper T (Tfh) cells form a distinct population of T-helper cells with different polarizations (type 1, type 2 and type 17) that regulates humoral responses and may participate in the pathophysiology of B-cell-mediate…
View article: Long-term Remission of Severe and Refractory Chronic Actinic Dermatosis with Dupilumab: A Case Report with Review of the Literature
Long-term Remission of Severe and Refractory Chronic Actinic Dermatosis with Dupilumab: A Case Report with Review of the Literature Open
is missing (Short communication)
View article: Treatment of moderate-to-severe psoriasis in adults: An expert consensus statement using a Delphi method to produce a decision-making algorithm
Treatment of moderate-to-severe psoriasis in adults: An expert consensus statement using a Delphi method to produce a decision-making algorithm Open
This expert consensus statement indicate that newly available IL-17 and IL-23 inhibitors may be favored over TNF and IL-12/23 inhibitors as first-line biologics. The Centre of Evidence of the French Society of Dermatology has drawn up a de…
View article: Long-term Efficacy of Dupilumab in Papulo-erythroderma of Ofuji
Long-term Efficacy of Dupilumab in Papulo-erythroderma of Ofuji Open
is missing (Short communication)
View article: Generalized pustular psoriasis: A nationwide population‐based study using the National Health Data System in France
Generalized pustular psoriasis: A nationwide population‐based study using the National Health Data System in France Open
Background GPP is a rare, chronic, neutrophilic skin disease, with limited real‐world data characterizing patients with flares and the impact of flares on disease progression and morbidity. Objective Describe the clinical characteristics o…
View article: 3D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System
3D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System Open
Routine clinical assays, such as conventional immunohistochemistry, often fail to resolve the regional heterogeneity of complex inflammatory skin conditions. We introduce MANTIS (Multiplex Annotated Tissue Imaging System), a flexible analy…
View article: Efficacy and Safety of Abrocitinib in Patients with Severe and/or Difficult-to-Treat Atopic Dermatitis: A Post Hoc Analysis of the Randomized Phase 3 JADE COMPARE Trial
Efficacy and Safety of Abrocitinib in Patients with Severe and/or Difficult-to-Treat Atopic Dermatitis: A Post Hoc Analysis of the Randomized Phase 3 JADE COMPARE Trial Open
ClinicalTrials.gov, NCT03720470.
View article: Rituximab tunes desmoglein-3-specific follicular T cells in patients with pemphigus vulgaris
Rituximab tunes desmoglein-3-specific follicular T cells in patients with pemphigus vulgaris Open
Background : Pemphigus vulgaris (PV) is characterized by pathogenic auto-antibodies targeting interkeratinocytes desmoglein (Dsg) 1 and 3, and by the HLA-DRB1-0402 predisposition allele. Treatment using rituximab (RTX) combined with short-…
View article: Human papilloma virus‐16‐specific<scp>CD8</scp>+ T‐cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus
Human papilloma virus‐16‐specific<span>CD8</span>+ T‐cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus Open
Lichen planus (LP) is a cutaneomucosal chronic inflammatory disease characterized by a CD8 + cytotoxic T‐lymphocytes (CTL) infiltrate. In erosive oral LP, we found HPV16‐specific activated CTL in lesions, supporting a pathogenic contributi…
View article: 3-D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System (MANTIS)
3-D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System (MANTIS) Open
Routine clinical assays, such as conventional immunohistochemistry, often fail to resolve the regional heterogeneity of complex inflammatory skin conditions. Here we introduce MANTIS (Multiplexed Annotated Tissue Imaging System), a flexibl…
View article: Prevalence, comorbidities and mortality of generalized pustular psoriasis: A literature review
Prevalence, comorbidities and mortality of generalized pustular psoriasis: A literature review Open
Generalized pustular psoriasis (GPP) is a rare auto‐inflammatory skin disease characterised by acute episodes of sterile pustule formation. Diagnosis and treatment of the disease have historically been complicated by a lack of awareness, a…
View article: <b>Switches between biologics in patients with moderate‐to‐severe psoriasis: results from the French cohort</b><scp>PSOBIOTEQ</scp>
<b>Switches between biologics in patients with moderate‐to‐severe psoriasis: results from the French cohort</b><span>PSOBIOTEQ</span> Open
Background Biologics are the cornerstone of treatment of patients with moderate‐to‐severe plaque psoriasis and switches between biologics are frequently needed to maintain clinical improvement over time. Objectives The main purpose of this…
View article: Impact of Childhood Onset Psoriasis on Addictive Behaviours, Socioeconomic and Educational Data in Adulthood
Impact of Childhood Onset Psoriasis on Addictive Behaviours, Socioeconomic and Educational Data in Adulthood Open
Paediatric psoriasis has been associated with school absenteeism, limitation of physical activities, psychiatric disorders and, in the longer term, with sexual dysfunction and addictions. This raises the hypothesis that childhood onset pso…
View article: Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort
Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort Open
Background Acral pustular disease within the pustular psoriasis/psoriasis‐like spectrum mainly includes palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH). Scarce data argue for a distinction between these two ent…
View article: Evolution of Drug Survival with Biological Agents and Apremilast Between 2012 and 2018 in Patients with Psoriasis from the PsoBioTeq Cohort
Evolution of Drug Survival with Biological Agents and Apremilast Between 2012 and 2018 in Patients with Psoriasis from the PsoBioTeq Cohort Open
Drug survival reflects treatment effectiveness and safety in real life. There is limited data on the variation of drug survival with the availability of systemic treatments with additional biological disease-modifying antirheumatic drugs (…
View article: Characteristics of patients with psoriasis with Psoriasis Area and Severity Index < 10 treated with biological agents: results from the French PsoBioTeq cohort
Characteristics of patients with psoriasis with Psoriasis Area and Severity Index < 10 treated with biological agents: results from the French PsoBioTeq cohort Open
International audience
View article: Impact of Bariatric Surgery on Hidradenitis Suppurativa
Impact of Bariatric Surgery on Hidradenitis Suppurativa Open
International audience
View article: Supplementary Material for: First-Line Biologic Therapy and Obesity in Moderate-to-Severe Psoriasis: Results from the Prospective Multicenter Cohort Psobioteq
Supplementary Material for: First-Line Biologic Therapy and Obesity in Moderate-to-Severe Psoriasis: Results from the Prospective Multicenter Cohort Psobioteq Open
Background: Obesity is associated with an increased risk of psoriasis. Objective: In this study, we examined whether body mass index (BMI) is taken into account when choosing first-line biologic therapy for psoriasis. Methods: In this coho…