Malcolm Reed
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View article: Between-hospital variability in the management and outcomes of postoperative periprosthetic femoral fractures
Between-hospital variability in the management and outcomes of postoperative periprosthetic femoral fractures Open
Aims Postoperative periprosthetic femoral fractures (POPFFs) following hip arthroplasty pose complex challenges, with differences in management and outcomes across healthcare facilities. However, there is limited published literature on su…
View article: Does candidate race influence simulated patient ratings in standardised assessments of clinical practice? A single-blinded randomised study in UK medical schools
Does candidate race influence simulated patient ratings in standardised assessments of clinical practice? A single-blinded randomised study in UK medical schools Open
Objectives Standardisation of medical examinations involves minimising assessor stereotyping and bias for a fair process. This study aimed to determine whether being a non-white candidate affected scoring by simulated patients, compared wi…
View article: Post-operative periprosthetic femoral fractures in England: Patient profiles and short-term outcomes
Post-operative periprosthetic femoral fractures in England: Patient profiles and short-term outcomes Open
This is the first national description of the burden of adverse outcomes for people with POPFF in England, of whom a large proportion require ongoing specialist support. Fewer POPFF cases follow prior hip fracture surgery than elective joi…
View article: Occupational support following arthroplasty of the lower limb (OPAL): trial protocol for a UK-wide phase III randomised controlled trial
Occupational support following arthroplasty of the lower limb (OPAL): trial protocol for a UK-wide phase III randomised controlled trial Open
Background In the UK, one in four patients are in work at the time of their hip or knee replacement surgery. These patients receive little support about their return to work (RTW). There is a need for an occupational support intervention t…
View article: Pressure-enhanced sensing of tissue oxygenation via endogenous porphyrin: Implications for dynamic visualization of cancer in surgery
Pressure-enhanced sensing of tissue oxygenation via endogenous porphyrin: Implications for dynamic visualization of cancer in surgery Open
Fluorescence guidance is routinely used in surgery to enhance perfusion contrast in multiple types of diseases. Pressure-enhanced sensing of tissue oxygenation (PRESTO) via fluorescence is a technique extensively analyzed here, that uses a…
View article: The Situational Judgement Test: not the right answer for UK Foundation Programme Allocation
The Situational Judgement Test: not the right answer for UK Foundation Programme Allocation Open
Editor – Allocation to UK Foundation Programme training posts has long been an issue of contention. Following recent analysis of the allocation process, the UK Foundation Programme Office has now moved away from the use of a Situational Ju…
View article: Automated Item Generation: impact of item variants on performance and standard setting
Automated Item Generation: impact of item variants on performance and standard setting Open
Background Automated Item Generation (AIG) uses computer software to create multiple items from a single question model. There is currently a lack of data looking at whether item variants to a single question result in differences in stude…
View article: The carbon footprint of products used in five common surgical operations: identifying contributing products and processes
The carbon footprint of products used in five common surgical operations: identifying contributing products and processes Open
Objectives Mitigating carbon footprint of products used in resource-intensive areas such as surgical operating rooms will be important in achieving net zero carbon healthcare. The aim of this study was to evaluate the carbon footprint of p…
View article: Supplemental Figure from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Supplemental Figure from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus Open
Supplemental Figure: Description of sample sets for the DNAseq and RNAseq experiments.
View article: Supplemental Methods and Supplemental Table from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Supplemental Methods and Supplemental Table from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus Open
Equations to calculate sample size in a homozygous discordant design. Supplemental Table: Sample size requirements (n in each group)
View article: Supplemental Methods and Supplemental Table from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Supplemental Methods and Supplemental Table from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus Open
Equations to calculate sample size in a homozygous discordant design. Supplemental Table: Sample size requirements (n in each group)
View article: Data from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Data from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus Open
The findings from genome-wide association studies hold enormous potential for novel insight into disease mechanisms. A major challenge in the field is to map these low-risk association signals to their underlying functional sequence varian…
View article: Data from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Data from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus Open
The findings from genome-wide association studies hold enormous potential for novel insight into disease mechanisms. A major challenge in the field is to map these low-risk association signals to their underlying functional sequence varian…
View article: Supplemental Figure Legend from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Supplemental Figure Legend from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus Open
Supplemental Figure Legend
View article: Supplemental Figure from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Supplemental Figure from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus Open
Supplemental Figure: Description of sample sets for the DNAseq and RNAseq experiments.
View article: Supplementary Figure 1, Tables 1-2 from Fine-Mapping <i>CASP8</i> Risk Variants in Breast Cancer
Supplementary Figure 1, Tables 1-2 from Fine-Mapping <i>CASP8</i> Risk Variants in Breast Cancer Open
PDF file - 410K
View article: Data from Fine-Mapping <i>CASP8</i> Risk Variants in Breast Cancer
Data from Fine-Mapping <i>CASP8</i> Risk Variants in Breast Cancer Open
Background: Multiple genome-wide and candidate gene association studies have been conducted in search of common risk variants for breast cancer. Recent large meta analyses, consolidating evidence from these studies, have been consistent in…
View article: Supplementary Figure 1, Tables 1-2 from Fine-Mapping <i>CASP8</i> Risk Variants in Breast Cancer
Supplementary Figure 1, Tables 1-2 from Fine-Mapping <i>CASP8</i> Risk Variants in Breast Cancer Open
PDF file - 410K
View article: Supplemental Figure Legend from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Supplemental Figure Legend from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus Open
Supplemental Figure Legend
View article: Data from Fine-Mapping <i>CASP8</i> Risk Variants in Breast Cancer
Data from Fine-Mapping <i>CASP8</i> Risk Variants in Breast Cancer Open
Background: Multiple genome-wide and candidate gene association studies have been conducted in search of common risk variants for breast cancer. Recent large meta analyses, consolidating evidence from these studies, have been consistent in…
View article: Automated Item Generation: – Impact of item variants on performance and standard setting
Automated Item Generation: – Impact of item variants on performance and standard setting Open
Background Automated Item Generation (AIG) uses computer software to create multiple items from a single question model. Items generated using AIG software have been shown to be of similar quality to those produced using traditional item w…
View article: The influence of candidates’ physical attributes on patient ratings in simulated assessments of clinical practice
The influence of candidates’ physical attributes on patient ratings in simulated assessments of clinical practice Open
The presence of certain physical attributes (tattoos or purple hair) was associated with higher scores given by patients to candidates in a simulated physical examination station.
View article: Life cycle assessment and life cycle cost of repairing surgical scissors
Life cycle assessment and life cycle cost of repairing surgical scissors Open
Purpose The primary objective of this study was to evaluate the environmental impact and financial cost of repairing surgical scissors. Methods We used life cycle assessment (LCA) and life cycle cost analysis to estimate environmental impa…
View article: Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT
Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT Open
Background In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit. This…