Maximilian J. Waldner
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View article: Calibration-free Laser-induced Breakdown Spectroscopy (CF-LIBS): Plasma criteria for porcine tissue
Calibration-free Laser-induced Breakdown Spectroscopy (CF-LIBS): Plasma criteria for porcine tissue Open
Laser-induced Breakdown Spectroscopy (LIBS) has established itself as a powerful analytical method in industrial applications, effectively analysing a wide range of materials such as metals and polymers, and even identifying the material c…
View article: Detecting immune cells with label-free two-photon autofluorescence and deep learning
Detecting immune cells with label-free two-photon autofluorescence and deep learning Open
Label-free imaging has gained broad interest because of its potential to omit elaborate staining procedures which is especially relevant for in vivo use. Label-free multiphoton microscopy (MPM), for instance, exploits two-photon excitation…
View article: IBUS‐SAS Is a Highly Accurate Intestinal Ultrasound Score for Predicting Endoscopic Disease Activity in Ulcerative Colitis
IBUS‐SAS Is a Highly Accurate Intestinal Ultrasound Score for Predicting Endoscopic Disease Activity in Ulcerative Colitis Open
Background The international bowel ultrasound group‐segmental activity score (IBUS‐SAS) is a validated tool with high interobserver agreement for accurately detecting disease activity in Crohn's disease (CD). Here, we addressed whether the…
View article: Glycan Atlassing: Nanoscale analysis of glycocalyx architecture enables functional tracing of cell state
Glycan Atlassing: Nanoscale analysis of glycocalyx architecture enables functional tracing of cell state Open
The glycocalyx is a complex layer of glycosylated biomolecules surrounding all cells in the human body. It is involved in the regulation of critical cellular processes such as immune response modulation, cell adhesion, and host-pathogen in…
View article: Derivation and validation of a non-invasive optoacoustic imaging biomarker for detection of patients with intermittent claudication
Derivation and validation of a non-invasive optoacoustic imaging biomarker for detection of patients with intermittent claudication Open
View article: Accuracy of superb microvascular imaging (SMI) in predicting endoscopic Crohn's disease activity
Accuracy of superb microvascular imaging (SMI) in predicting endoscopic Crohn's disease activity Open
SMI is a highly promising tool to improve or simplify the non-invasive assessment of disease activity in CD that should further be investigated in real-world and multi-center trials.
View article: Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation
Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation Open
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia with a massive burden on global health. The prevalence of AF increases dramatically with age and can be up to 18% in patients older than 80 years. Telomeres, which a…
View article: Guided Multispectral Optoacoustic Tomography for 3D Imaging of the Murine Colon
Guided Multispectral Optoacoustic Tomography for 3D Imaging of the Murine Colon Open
Multispectral optoacoustic tomography is a promising medical imaging modality that combines light and sound to provide molecular imaging information at depths of several centimeters, based on the optical absorption of endogenous chromophor…
View article: TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice
TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice Open
Intestinal immune homeostasis relies on intestinal epithelial cells (IECs), which provide an efficient barrier, and warrant a state of tolerance between the microbiome and the mucosal immune system. Thus, proper epithelial microbial sensin…
View article: In Vivo Assessment of Deep Vascular Patterns in Murine Colitis Using Optoacoustic Mesoscopic Imaging
In Vivo Assessment of Deep Vascular Patterns in Murine Colitis Using Optoacoustic Mesoscopic Imaging Open
The analysis of vascular morphology and functionality enables the assessment of disease activity and therapeutic effects in various pathologies. Raster‐scanning optoacoustic mesoscopy (RSOM) is an imaging modality that enables the visualiz…
View article: Teachability of multispectral optoacoustic tomography
Teachability of multispectral optoacoustic tomography Open
To date, the appropriate training required for the reproducible operation of multispectral optoacoustic tomography (MSOT) is poorly discussed. Therefore, the aim of this study was to assess the teachability of MSOT imaging. Five operators …
View article: Multispectral optoacoustic tomography of benign parotid tumors in vivo: a prospective observational pilot study
Multispectral optoacoustic tomography of benign parotid tumors in vivo: a prospective observational pilot study Open
Parotid lumps are a heterogeneous group of mainly benign but also malignant tumors. Preoperative imaging does not allow a differentiation between tumor types. Multispectral optoacoustic tomography (MSOT) may improve the preoperative diagno…
View article: Monitoring spinal muscular atrophy with three-dimensional optoacoustic imaging
Monitoring spinal muscular atrophy with three-dimensional optoacoustic imaging Open
The project was funded by ELAN Fonds (P055) at the University Hospital of the Friedrich-Alexander-Universität (FAU) Erlangen-Nurnberg to A.P.R.
View article: Ultrasound Diagnosis of Hepatocellular Carcinoma: Is the Future Defined by Artificial Intelligence?
Ultrasound Diagnosis of Hepatocellular Carcinoma: Is the Future Defined by Artificial Intelligence? Open
Technological progress and the development of complex mathematical models that allow the analysis of large and partially unstructured data have led to the rapid development of artificial intelligence (AI) since the 2010 s [1]. New AI appli…
View article: Metabolic and molecular imaging in inflammatory arthritis
Metabolic and molecular imaging in inflammatory arthritis Open
It is known that metabolic shifts and tissue remodelling precede the development of visible inflammation and structural organ damage in inflammatory rheumatic diseases such as the inflammatory arthritides. As such, visualising and measurin…
View article: Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease
Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease Open
View article: Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease
Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease Open
Multispectral optoacoustic tomography (MSOT) allows non-invasive molecular disease activity assessment in adults with inflammatory bowel disease (IBD). In this prospective pilot-study, we investigated, whether increased levels of MSOT haem…
View article: Derivation and validation of a non-invasive optoacoustic imaging biomarker for patients with intermittent claudication
Derivation and validation of a non-invasive optoacoustic imaging biomarker for patients with intermittent claudication Open
Background Multispectral optoacoustic tomography (MSOT), a molecular sensitive ultrasound, offers a non-invasive diagnostic approach to image the deep-tissue biomarkers. Objectives The authors aimed to investigate the diagnostic accuracy o…
View article: Healing of the epithelial barrier in the ileum is superior to endoscopic and histologic remission for predicting major adverse outcomes in ulcerative colitis
Healing of the epithelial barrier in the ileum is superior to endoscopic and histologic remission for predicting major adverse outcomes in ulcerative colitis Open
Background Achieving endoscopic remission is a key therapeutic goal in patients with ulcerative colitis (UC) that is associated with favorable long-term disease outcomes. Here, we prospectively compared the predictive value of endoscopic a…
View article: Contrast‐Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract
Contrast‐Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract Open
Real‐time imaging and functional assessment of the intestinal tract and its transit pose a significant challenge to conventional clinical diagnostic methods. Multispectral optoacoustic tomography (MSOT), a molecular‐sensitive imaging techn…
View article: Issue Information
Issue Information Open
View article: Transrectal Absorber Guide Raster‐Scanning Optoacoustic Mesoscopy for Label‐Free In Vivo Assessment of Colitis
Transrectal Absorber Guide Raster‐Scanning Optoacoustic Mesoscopy for Label‐Free In Vivo Assessment of Colitis Open
Optoacoustic imaging (OAI) enables microscale imaging of endogenous chromophores such as hemoglobin at significantly higher penetration depths compared to other optical imaging technologies. Raster‐scanning optoacoustic mesoscopy (RSOM) ha…
View article: Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies
Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies Open
During surgery, rapid and accurate histopathological diagnosis is essential for clinical decision making. Yet the prevalent method of intra-operative consultation pathology is intensive in time, labour and costs, and requires the expertise…
View article: Anti‐β7 integrin treatment impedes the recruitment on non‐classical monocytes to the gut and delays macrophage‐mediated intestinal wound healing
Anti‐β7 integrin treatment impedes the recruitment on non‐classical monocytes to the gut and delays macrophage‐mediated intestinal wound healing Open
Background Closing mucosal defects to reach mucosal healing is an important goal of therapy in inflammatory bowel disease (IBD). Among other cells, monocyte‐derived macrophages are centrally involved in such intestinal wound healing. We ha…
View article: Data from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Data from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells Open
Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with epithelial-…
View article: Supplementary Table from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Supplementary Table from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells Open
List of differentially expressed genes in all analyzed datasets
View article: Supplementary Figures from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Supplementary Figures from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells Open
SUPPLEMENTARY FIGURE 1 Correlation of VIM/CDH1 ratios in different datasets. The list of 35 genes significantly correlated with EMT. Lack of correlation between AKR1B10 mRNA levels and EMT. SUPPLEMENTARY FIGURE 2 AKR1B1 levels are modulate…
View article: Supplementary Table from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Supplementary Table from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells Open
List of differentially expressed genes in all analyzed datasets
View article: Data from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Data from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells Open
Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with epithelial-…
View article: Supplementary Figures from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Supplementary Figures from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells Open
SUPPLEMENTARY FIGURE 1 Correlation of VIM/CDH1 ratios in different datasets. The list of 35 genes significantly correlated with EMT. Lack of correlation between AKR1B10 mRNA levels and EMT. SUPPLEMENTARY FIGURE 2 AKR1B1 levels are modulate…