Michael D. Ward
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View article: Nanoplastic Contamination Across Common Beverages and Infant Food: An Assessment of Packaging Influence
Nanoplastic Contamination Across Common Beverages and Infant Food: An Assessment of Packaging Influence Open
The widespread presence of nanoplastics (NPs) in the environment creates a significant and growing concern for global health, with ingestion, inhalation, and dermal contact identified as primary exposure pathways. Despite their documented …
View article: Ultrafast Photoinduced Electron Transfer Between Donor (Eosin‐Y) and Acceptor (Naphthoquinone) in a Supramolecular Array Based on a Coordination Cage Host
Ultrafast Photoinduced Electron Transfer Between Donor (Eosin‐Y) and Acceptor (Naphthoquinone) in a Supramolecular Array Based on a Coordination Cage Host Open
An octanuclear M 8 L 12 coordination cage host ( H PEG ⋅ M ) in aqueous solution binds neutral electron‐accepting guests such as naphthoquinone ( NQ ) in its central cavity via the hydrophobic effect, and multiple anionic photosensitisers …
View article: An investigation into catalysed xanthene-based dye oxidation by a family of coordination cages
An investigation into catalysed xanthene-based dye oxidation by a family of coordination cages Open
A Co 8 coordination cage simultaneously binds xanthene dyes around the surface, and performs redox activation of peroxymonosulfate to SO 4 ˙ − , allowing catalysed oxidative degradation of the dyes.
View article: Prospective Investigation of Nanoplastic Accumulation in Healthy Subjects, Autoimmune Diseases, Hematological Malignancies, Lung Cancer, and Murine Models
Prospective Investigation of Nanoplastic Accumulation in Healthy Subjects, Autoimmune Diseases, Hematological Malignancies, Lung Cancer, and Murine Models Open
Nanoplastics (NPs) and microplastics (MPs) are an emerging threat to global health. They negatively impact ecosystems and many physiological processes, causing alterations in xenobiotic metabolism, nutrient uptake, energy metabolism, or cy…
View article: Prognostic Significance of PD-L1 Expression on Circulating Myeloid-Derived Suppressor Cells in NSCLC Patients Treated with Anti-PD-1/PD-L1 Checkpoint Inhibitors
Prognostic Significance of PD-L1 Expression on Circulating Myeloid-Derived Suppressor Cells in NSCLC Patients Treated with Anti-PD-1/PD-L1 Checkpoint Inhibitors Open
Even though anti-PD-1/PD-L1 immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC) have improved survival, a high percentage of patients still do not respond to ICIs. Myeloid-derived suppressor cells (MDSCs) are circulat…
View article: Structural Analysis of Coordination Cage/Guest Complexes Prepared with the ‘Crystalline Sponge’ Methodology
Structural Analysis of Coordination Cage/Guest Complexes Prepared with the ‘Crystalline Sponge’ Methodology Open
The crystalline sponge method has proven invaluable in the preparation and analysis of supramolecular host/guest complexes if the host can be obtained in a suitable crystalline form, allowing the analysis of guest binding modes inside host…
View article: Advances in the Computational Assessment of Disturbed Coronary Flow and Wall Shear Stress: A Contemporary Review
Advances in the Computational Assessment of Disturbed Coronary Flow and Wall Shear Stress: A Contemporary Review Open
Coronary artery blood flow is influenced by various factors including vessel geometry, hemodynamic conditions, timing in the cardiac cycle, and rheological conditions. Multiple patterns of disturbed coronary flow may occur when blood flow …
View article: A Study on Auto‐Catalysis and Product Inhibition: A Nucleophilic Aromatic Substitution Reaction Catalysed within the Cavity of an Octanuclear Coordination Cage
A Study on Auto‐Catalysis and Product Inhibition: A Nucleophilic Aromatic Substitution Reaction Catalysed within the Cavity of an Octanuclear Coordination Cage Open
The ability of an octanuclear cubic coordination cage to catalyse a nucleophilic aromatic substitution reaction on a cavity‐bound guest was studied with 2,4‐dinitrofluorobenzene (DNFB) as the guest/substrate. It was found that DNFB undergo…
View article: Persistence of Chronic Lymphocytic Leukemia Stem-like Populations under Simultaneous In Vitro Treatment with Curcumin, Fludarabine, and Ibrutinib: Implications for Therapy Resistance
Persistence of Chronic Lymphocytic Leukemia Stem-like Populations under Simultaneous In Vitro Treatment with Curcumin, Fludarabine, and Ibrutinib: Implications for Therapy Resistance Open
Leukemic stem cells (LSCs) possess similar characteristics to normal hematopoietic stem cells, including self-renewal capacity, quiescence, ability to initiate leukemia, and drug resistance. These cells play a significant role in leukemia …
View article: Photoswitching of Co(<scp>ii</scp>)-based coordination cages containing azobenzene backbones
Photoswitching of Co(<span>ii</span>)-based coordination cages containing azobenzene backbones Open
Incorporation of a photoswitchable azobenzene unit into a ditopic bis(pyrazolyl-pyridine) ligand allows a range of reversible light-induced transformations between different cage assemblies.
View article: Coordination-cage binding and catalysed hydrolysis of organophosphorus chemical warfare agent simulants
Coordination-cage binding and catalysed hydrolysis of organophosphorus chemical warfare agent simulants Open
Simulants of organophosphate chemical warfare agents can bind in the cavity of an octanuclear coordination cage (the figure shows a carbonate-based guest), resulting in some cases in catalysed hydrolytic decomposition.
View article: New insights into coordination-cage based catalysis
New insights into coordination-cage based catalysis Open
Recent work on catalysed reactions using coordination cage hosts, including new mechanistic insights and reactions types, is reviewed.
View article: Correction: Cu(<scp>i</scp>) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light
Correction: Cu(<span>i</span>) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light Open
Correction for ‘Cu( i ) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light’ by Martin V. Appleby et al. , Mater. Adv. , 2020, 1 , 3417–3427, https://doi.org/10.1039/D0MA00642D.
View article: CCDC 2279872: Experimental Crystal Structure Determination
CCDC 2279872: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2279871: Experimental Crystal Structure Determination
CCDC 2279871: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2279869: Experimental Crystal Structure Determination
CCDC 2279869: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2279870: Experimental Crystal Structure Determination
CCDC 2279870: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2279873: Experimental Crystal Structure Determination
CCDC 2279873: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Mechanism of Oxygen Quenching of the Excited States of Heteroleptic Chromium(III) Phenanthroline Derivatives
Mechanism of Oxygen Quenching of the Excited States of Heteroleptic Chromium(III) Phenanthroline Derivatives Open
In this study, we report the synthesis and characterization of some heteroleptic Cr(III) complexes of the form [Cr(Phen)2L](OTf)3, where Phen = 1,10-phenanthroline and L is either 2,2'-bipyridine (bpy) or its derivatives, such as 4,4'-dime…
View article: Binding Modes of High Stoichiometry Guest Complexes with a Co8L12 Cage Uncovered by Mass Spectrometry
Binding Modes of High Stoichiometry Guest Complexes with a Co8L12 Cage Uncovered by Mass Spectrometry Open
We demonstrate how different modes of guest binding to a Co8L12 cubic cage host can be determined using ESI-MS. High stoichiometry guest binding was observed, with binding modes which showed the guests preferentially binding externally, bu…
View article: Programmable Monodisperse Glyco-Multivalency Using Self-Assembled Coordination Cages as Scaffolds
Programmable Monodisperse Glyco-Multivalency Using Self-Assembled Coordination Cages as Scaffolds Open
The multivalent presentation of glycans leads to enhanced binding avidity to lectins due to the cluster glycoside effect. Most materials used as scaffolds for multivalent glycan arrays, such as polymers or nanoparticles, have intrinsic dis…
View article: The preservation of sarin and O,O’-diisopropyl fluorophosphate inside coordination cage hosts
The preservation of sarin and O,O’-diisopropyl fluorophosphate inside coordination cage hosts Open
The host-guest chemistry of O,O-diisopropyl fluorophosphate (DFP), a phosphonofluoridate G-series chemical warfare agent simulant, in the presence of a number of octanuclear cubic coordination cages was investigated. The aim was to demonst…
View article: CCDC 2206745: Experimental Crystal Structure Determination
CCDC 2206745: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Systems and methods for separating particles utilizing engineered acoustic contrast capture particles
Systems and methods for separating particles utilizing engineered acoustic contrast capture particles Open
An apparatus for separating particles from a medium includes a capillary defining a flow path therein that is in fluid communication with a medium source. The medium source includes engineered acoustic contrast capture particle having a pr…