Xiaomin Niu
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View article: Immunotherapy for small cell lung cancer: current challenges and prospects
Immunotherapy for small cell lung cancer: current challenges and prospects Open
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy with limited treatment options. While immunotherapy has revolutionized SCLC therapy and now serves as a front-line treatment, the disease continues to present s…
View article: Mediating roles of social connection and stress-coping self-efficacy in the association between physical activity and emotional distress among lung cancer survivors: a cross-sectional study
Mediating roles of social connection and stress-coping self-efficacy in the association between physical activity and emotional distress among lung cancer survivors: a cross-sectional study Open
Objectives Although previous studies have examined the psychological benefits of physical activity in cancer survivors, the underlying psychological mechanisms among lung cancer survivors remain poorly understood. This study aims to examin…
View article: Oral nanoliposomes functionalized with cRGD and polydopamine for enhanced antimalarial efficacy of disulfide bond-modified dihydroartemisinin prodrug
Oral nanoliposomes functionalized with cRGD and polydopamine for enhanced antimalarial efficacy of disulfide bond-modified dihydroartemisinin prodrug Open
Malaria remains a global health crisis, with Plasmodium resistance underscoring the urgent need for advanced drug delivery strategies. To overcome the limitations of oral antimalarials, such as hepatic first-pass metabolism and insu…
View article: METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner
METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner Open
Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosi…
View article: Immunotherapy resistance in non-small cell lung cancer: from mechanisms to therapeutic opportunities
Immunotherapy resistance in non-small cell lung cancer: from mechanisms to therapeutic opportunities Open
This review provides a comprehensive synthesis of current knowledge on immunotherapy resistance in non-small cell lung cancer (NSCLC), a disease that accounts for approximately 85% of all lung cancer cases and remains the leading cause of …
View article: Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis
Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis Open
Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is a rare malignancy originating from mesothelial cells of the testicular tunica vaginalis. Due to its insidious onset and local aggressiveness, most patients are diagnosed at a…
View article: Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma
Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma Open
Primary malignant pericardial mesothelioma (PMPM), a rare pericardium‐derived malignancy, urgently requires standardized diagnostic and therapeutic protocols. This consensus, established by the Chinese Alliance of Research for Mesothelioma…
View article: Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration
Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration Open
Alterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances in precision therapies targeting MET alterations have significantly expanded treatm…
View article: Role of SMOC2 in adenomyosis: implications for ECM remodeling and EMT pathogenesis
Role of SMOC2 in adenomyosis: implications for ECM remodeling and EMT pathogenesis Open
View article: NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer
NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer Open
Background Tumor immune evasion extends beyond T cells, affecting innate immune elements like natural killer cells (NK) and macrophages within the tumor-immune microenvironment (TIME). Nevertheless, translational strategies to trigger coll…
View article: Plasma Proteomics Profiling Identifies Predictive Biomarkers for Immunotherapy Response In Small-Cell Lung Cancer
Plasma Proteomics Profiling Identifies Predictive Biomarkers for Immunotherapy Response In Small-Cell Lung Cancer Open
View article: [E<sub>2</sub> signaling in myofibers promots macrophage efferocytosis in mouse skeletal muscles with cardiotoxin-induced acute injury].
[E<sub>2</sub> signaling in myofibers promots macrophage efferocytosis in mouse skeletal muscles with cardiotoxin-induced acute injury]. Open
In injured mouse skeletal muscles, myofiber E2 signaling promotes M1 to M2 transition to increase macrophage efferocytosis, thereby relieving inflammation and promoting muscle regeneration and repair.
View article: RPS6KA1 is a histone acetylation-related oncoprotein in acute myeloid leukemia which is targeted by afzelin
RPS6KA1 is a histone acetylation-related oncoprotein in acute myeloid leukemia which is targeted by afzelin Open
View article: Evaluation of the therapeutic effects of rehabilitation therapy on patients with amyotrophic lateral sclerosis—a meta-analysis
Evaluation of the therapeutic effects of rehabilitation therapy on patients with amyotrophic lateral sclerosis—a meta-analysis Open
Objective To investigate the effect of rehabilitation therapy on the global function, respiratory function, and quality of life in patients with amyotrophic lateral sclerosis (ALS). Methods PubMed, Web of Science, and The National Library …
View article: Current status and continuing medical education need for general practitioners in Tibet, China: a cross-sectional study
Current status and continuing medical education need for general practitioners in Tibet, China: a cross-sectional study Open
View article: Development and Evaluation of a Quantitative Systems Pharmacology Model for Mechanism Interpretation and Efficacy Prediction of Atezolizumab in Combination with Carboplatin and Nab-Paclitaxel in Patients with Non-Small-Cell Lung Cancer
Development and Evaluation of a Quantitative Systems Pharmacology Model for Mechanism Interpretation and Efficacy Prediction of Atezolizumab in Combination with Carboplatin and Nab-Paclitaxel in Patients with Non-Small-Cell Lung Cancer Open
Immunotherapy has shown clinical benefit in patients with non-small-cell lung cancer (NSCLC). Due to the limited response of monotherapy, combining immune checkpoint inhibitors (ICIs) and chemotherapy is considered a treatment option for a…
View article: Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice
Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice Open
To improve the efficacy of artemisinins against cerebral malaria (CM) in murine, dihydroartemisinin (DHA) and perillyl alcohol (POH) co-loaded liposomes (DP@Tyr-Lips) were designed and prepared, in which POH was expected to exert neuroprot…
View article: Cisplatin-induced Pyroptosis Enhances the Efficacy of PD-L1 Inhibitor in Small-Cell Lung Cancer via GSDME/IL12/CD4Tem Axis
Cisplatin-induced Pyroptosis Enhances the Efficacy of PD-L1 Inhibitor in Small-Cell Lung Cancer via GSDME/IL12/CD4Tem Axis Open
The combination therapy of platinum-based chemotherapy and PD-L1 inhibitors but not the single anti-PD-L1 therapy has significantly improved the prognosis of patients with small-cell lung cancer (SCLC). However, the synergistic mechanism o…
View article: Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma
Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma Open
Malignant pleural mesothelioma (MPM) is a malignant tumor originating from the pleura, and its incidence has been increasing in recent years. Due to the insidious onset and strong local invasiveness of MPM, most patients are diagnosed in t…
View article: A 3D Ex Vivo Tumor‐Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion (Adv. Biology 7/2023)
A 3D Ex Vivo Tumor‐Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion (Adv. Biology 7/2023) Open
3D Model CD8+ T Cells In article 2200264, Wenguo Cui, Ying Wang, Shun Lu, and co-workers established a tumor-immune microenvironment (TIME) mimicking a hydrogel-based 3D microsphere co-culturing system (3D-HYGTIC). During long-term co-cult…
View article: Data from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment
Data from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment Open
Purpose: The past decade has witnessed the rapid development of personalized targeted therapies in lung cancer. It is still unclear whether epigenetic changes are involved in the response to tyrosine kinase inhibitor (TKI) treatment…
View article: Data from Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer
Data from Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer Open
Purpose:Activation of NFE2L2 has been linked to chemoresistance in cell line models. Recently, somatic mutations that activate NFE2L2, including mutations in NFE2L2, KEAP1, or CUL3, have been found to be associated with poor …
View article: Supplementary Data from Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer
Supplementary Data from Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer Open
Legend for supplementary figure
View article: Supplementary File from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment
Supplementary File from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment Open
Supplementary Methods and Figure legend of Supplementary Figure S1.
View article: Data from Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer
Data from Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer Open
Purpose:Activation of NFE2L2 has been linked to chemoresistance in cell line models. Recently, somatic mutations that activate NFE2L2, including mutations in NFE2L2, KEAP1, or CUL3, have been found to be associated with poor …
View article: Table S2 from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment
Table S2 from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment Open
Sixty erlotinib-related aberrant DNA methylation genes in both patients discovered with the the methyl-sensitive cut counting sequencing (MSCC) screening method.
View article: Table S3 from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment
Table S3 from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment Open
DNA methylation results of GABAA receptor families was relatively conservative before and after erlotinib treatment in both patients using methyl-sensitive cut counting sequencing (MSCC) screening method.
View article: Table S2 from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment
Table S2 from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment Open
Sixty erlotinib-related aberrant DNA methylation genes in both patients discovered with the the methyl-sensitive cut counting sequencing (MSCC) screening method.
View article: Supplementary File from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment
Supplementary File from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment Open
Supplementary Methods and Figure legend of Supplementary Figure S1.
View article: Table S1 from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment
Table S1 from Genome-wide DNA Methylation Analysis Reveals <i>GABBR2</i> as a Novel Epigenetic Target for <i>EGFR</i> 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment Open
Data summary of methyl-sensitive cut counting sequencing (MSCC) sequencing of the 4 samples (8 libraries).