M. Zaeem Cader
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View article: A purine metabolic checkpoint that prevents autoimmunity and autoinflammation
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation Open
Still's disease, the paradigm of autoinflammation-cum-autoimmunity, predisposes for a cytokine storm with excessive T lymphocyte activation upon viral infection. Loss of function of the purine nucleoside enzyme FAMIN is the sole known caus…
View article: Acute Upper GI Bleeding: Good Night, Sleep Tight, Endoscopy Can Wait until Morning Light
Acute Upper GI Bleeding: Good Night, Sleep Tight, Endoscopy Can Wait until Morning Light Open
View article: GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation Open
View article: Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis Open
IgG antibodies cause inflammation and organ damage in autoimmune diseases such as systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages isolated from inflamed tissues in immune complex (IC)-associated dis…
View article: FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle
FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle Open
(Cell 180, 278–295.e1–e23, January 23, 2020) Due to a production error, the last name of author Ana Belén Iglesias-Romero was misspelled as “Inglesias-Romero.” This error has been corrected online, and we apologize for any confusion we may…
View article: FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle
FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle Open
Mutations in FAMIN cause arthritis and inflammatory bowel disease in early childhood, and a common genetic variant increases risk for Crohn’s disease and leprosy. We developed an unbiased liquid chromatography mass spectrometry screen for …
View article: GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump
GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump Open
A GPCR–Na/K-ATPase interaction alters metabolism and proliferation to enhance intestinal tumor formation.
View article: The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development
The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development Open
US-defined digit flexor TS provided independent predictive data for persistent RA development in patients with early arthritis. The predictive utility of this tendon site should be further assessed in a larger cohort; investigators designi…
View article: C13orf31 (FAMIN) is a central regulator of immunometabolic function
C13orf31 (FAMIN) is a central regulator of immunometabolic function Open
View article: O21. Ultrasound-Defined Tenosynovitis Improves the Prediction of Early Rheumatoid Arthritis
O21. Ultrasound-Defined Tenosynovitis Improves the Prediction of Early Rheumatoid Arthritis Open