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View article: Spatio-Temporal Variations and the Climatic and Human Activity Driving Factor Analysis of Net Primary Productivity(2000–2022) in the Qinling Shaanxi Section of China
Spatio-Temporal Variations and the Climatic and Human Activity Driving Factor Analysis of Net Primary Productivity(2000–2022) in the Qinling Shaanxi Section of China Open
The Qinling Mountains plays an important geographical and climatic divide between northern and southern China, influencing vegetation dynamics and carbon sequestration. We investigate the spatiotemporal variations in net primary productivi…
View article: Magnesium-containing implants enhance bone healing: A mechanobiological perspective
Magnesium-containing implants enhance bone healing: A mechanobiological perspective Open
Unlike traditional implants primarily composed of bioinert materials, magnesium (Mg) -a degradable biomaterial - offers significant promise for next-generation bone healing implants, whether utilized as a primary structural component or a …
View article: Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation
Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation Open
Incomplete radiofrequency ablation (iRFA) of hepatocellular carcinoma (HCC) has the risk to exacerbate the tumor immunosuppressive microenvironment and promote lung metastasis. There is an urgent need to reverse the immunosuppressive micro…
View article: Identification of Risk Factors for Relapse following Rituximab Therapy in Children with Steroid-Sensitive Nephrotic Syndrome
Identification of Risk Factors for Relapse following Rituximab Therapy in Children with Steroid-Sensitive Nephrotic Syndrome Open
Introduction: Rituximab (RTX) is a key therapeutic agent for maintaining remission in steroid-dependent nephrotic syndrome and frequently relapsing nephrotic syndrome, demonstrating both efficacy and safety. However, reliable biomarkers fo…
View article: Gut microbiota therapy for chronic kidney disease
Gut microbiota therapy for chronic kidney disease Open
Chronic kidney disease (CKD), affecting 13% of the global population, is increasingly linked to gut microbiota dysbiosis, a condition driven by uremic toxins accumulation, metabolic alterations, and dietary factors. This mini review explor…
View article: Antidepressant Effect of Propofol and Its Acute Alterations in Prefrontal-Temporal Cortical Blood Flow in Patients with Depressive Disorder: A Functional Near-Infrared Spectroscopy Study with a Small Sample Size
Antidepressant Effect of Propofol and Its Acute Alterations in Prefrontal-Temporal Cortical Blood Flow in Patients with Depressive Disorder: A Functional Near-Infrared Spectroscopy Study with a Small Sample Size Open
Objective: To investigate the characteristics and significance of near-infrared brain function imaging in patients with depressive disorder after administration of propofol injection. Methods: A total of 28 subjects with depressive disorde…
View article: Identification of Neutrophil Extracellular Trap-Related Biomarkers in Diabetic Foot Ulcers Based on Bioinformatics
Identification of Neutrophil Extracellular Trap-Related Biomarkers in Diabetic Foot Ulcers Based on Bioinformatics Open
This study revealed the potential molecular mechanisms of NETRGs in DFUs, which could provide novel insights for the clinical diagnosis and treatment of DFUs.
View article: Prophylactic Effect of Prefrontal Alternating Current Stimulation on Postoperative Sleep Disturbance in Patients Undergoing Gynecological Laparoscope: A Randomized, Double‐Blind, Sham‐Controlled Trial
Prophylactic Effect of Prefrontal Alternating Current Stimulation on Postoperative Sleep Disturbance in Patients Undergoing Gynecological Laparoscope: A Randomized, Double‐Blind, Sham‐Controlled Trial Open
Aims Postoperative sleep disturbance (PSD) is a common complication following surgical procedures. We aimed to evaluate the effect of prefrontal transcranial alternating current stimulation (tACS) in preventing PSD among patients undergoin…
View article: MiroMind-M1: An Open-Source Advancement in Mathematical Reasoning via Context-Aware Multi-Stage Policy Optimization
MiroMind-M1: An Open-Source Advancement in Mathematical Reasoning via Context-Aware Multi-Stage Policy Optimization Open
Large language models have recently evolved from fluent text generation to advanced reasoning across diverse domains, giving rise to reasoning language models. Among these domains, mathematical reasoning serves as a representative benchmar…
View article: Lesional Macrophage‐Targeted Nanomedicine Regulating Cholesterol Homeostasis for the Treatment of Atherosclerosis
Lesional Macrophage‐Targeted Nanomedicine Regulating Cholesterol Homeostasis for the Treatment of Atherosclerosis Open
The accumulation of atherosclerosis plaques within arterial walls leads to cardiovascular events. Lipid‐laden macrophages, known as foam cells play a pivotal role in atherosclerotic plaque progression by disrupting cholesterol homeostasis …
View article: Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG
Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG Open
This study identified six genes associated with POAG, three of which were novel, offering novel insights into its genetic architecture and systemic regulatory mechanisms.
View article: Comparison of the effects of ice saline and kangfuxin mouthwash on improving oral infection following buccal mucosa resection
Comparison of the effects of ice saline and kangfuxin mouthwash on improving oral infection following buccal mucosa resection Open
Not applicable.
View article: Multiple strategies were adopted to optimize the enzymatic characteristics and improve the expression of bovine chymosin BtChy in Kluyveromyces lactis for cheese production
Multiple strategies were adopted to optimize the enzymatic characteristics and improve the expression of bovine chymosin BtChy in Kluyveromyces lactis for cheese production Open
Chymosin (EC3.4.23.4), primarily sourced from calf abomasum, serves as a conventional coagulant in milk curdling during cheese production. To improve the enzymatic properties and enhance the expression of calf chymosin (BtChy) in Kluyverom…
View article: Bisecting GlcNAc expression by bone marrow stromal cells modulates TGF-β1-driven macrophage polarization in myeloid leukemias
Bisecting GlcNAc expression by bone marrow stromal cells modulates TGF-β1-driven macrophage polarization in myeloid leukemias Open
Accumulating evidence have highlighted the critical role of tumor-associated macrophages (TAMs) in promoting immune evasion and disease progression in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Combined single-cell R…
View article: A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition
A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition Open
Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen species (ROS) and triggering immunogenic cell death. However, the therapeutic effect of PDT is strongly limited by tumor hypoxia and immunosupp…
View article: Identification of Risk Factors for Relapse Following Rituximab Therapy in Children with Steroid-Sensitive Nephrotic Syndrome
Identification of Risk Factors for Relapse Following Rituximab Therapy in Children with Steroid-Sensitive Nephrotic Syndrome Open
Background Rituximab (RTX) is a key therapeutic agent for maintaining remission in steroid-dependent nephrotic syndrome (SDNS) and frequently relapsing nephrotic syndrome (FRNS), demonstrating both efficacy and safety. However, relapse ris…
View article: Dietary fatty acids promote gut health in weaned piglets by regulating gut microbiota and immune function
Dietary fatty acids promote gut health in weaned piglets by regulating gut microbiota and immune function Open
Background Post-weaning diarrhea in piglets is a common challenge that adversely impacts growth performance and increases mortality, leading to severe economic losses. Medium-chain fatty acids (MCFA) and short-chain fatty acids (SCFA) are …
View article: Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse
Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse Open
Our findings provide novel insights into the metabolic mechanisms underlying GVHD and relapse after allo-HSCT. Identified metabolites, particularly pyridoxate, may serve as potential therapeutic targets for GVHD prevention and management.
View article: Mechanism of Action of Exercise in Regulating Spontaneous Hypertension through the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling Pathway
Mechanism of Action of Exercise in Regulating Spontaneous Hypertension through the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling Pathway Open
Although blood pressure can be regulated to normal levels through drug intervention, the prognosis for patients remains bleak, and there is an urgent need to find a new way to prevent or reverse hypertension and its adverse consequences. S…
View article: Tandem metabolic reaction–based sensors unlock in vivo metabolomics
Tandem metabolic reaction–based sensors unlock in vivo metabolomics Open
Mimicking metabolic pathways on electrodes enables in vivo metabolite monitoring for decoding metabolism. Conventional in vivo sensors cannot accommodate underlying complex reactions involving multiple enzymes and cofactors, addressing onl…
View article: Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis
Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis Open
Background Obesity and hypercholesterolemia independently increase cardiovascular disease risk. This analysis evaluated the efficacy and safety of bempedoic acid in people with obesity participating in the CLEAR (Cholesterol Lowering via B…
View article: O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation
O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation Open
Fat mass and obesity-associated protein (FTO) was the first m6A demethylase identified, which is responsible for eliminating m6A modifications in target RNAs. While it is well-established that numerous cytosolic and nuclear proteins underg…
View article: Risk Factors of Mortality and Clinical Characteristics in Descending Necrotizing Mediastinitis: A Retrospective Evaluation of 181 Patients
Risk Factors of Mortality and Clinical Characteristics in Descending Necrotizing Mediastinitis: A Retrospective Evaluation of 181 Patients Open
Objectives: Descending necrotizing mediastinitis (DNM) is a serious infection with a high-mortality rate. However, large-scale studies analyzing the clinical characteristics and risk factors of mortality in DNM are rare. This study aimed t…
View article: Rapid diagnosis of <i>Mycoplasma pneumoniae</i> and prediction of antibiotic resistance by nanopore adaptive sampling
Rapid diagnosis of <i>Mycoplasma pneumoniae</i> and prediction of antibiotic resistance by nanopore adaptive sampling Open
Background Microbial infections, particularly in children, require rapid and accurate diagnostics. It is difficult to differentiate pathogens from commensal organisms, and it is impossible to identify antibiotic resistance genes that belon…