M. Anthony Moody
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View article: Terahertz generation of BNA derivatives
Terahertz generation of BNA derivatives Open
N-Benzyl-2-methyl-4-nitroanaline (BNA) is currently the industry standard for terahertz generation at 800 nm using organic materials. We developed four derivatives of BNA by replacing a hydrogen atom on the benzyl substituent with either a…
View article: Mechanisms of early-life immunity associated with induction of heterologous HIV-1 neutralizing antibodies 9283
Mechanisms of early-life immunity associated with induction of heterologous HIV-1 neutralizing antibodies 9283 Open
Description A goal of an HIV-1 vaccine is induction of broadly neutralizing antibodies (bnAbs) that prevent infection of different strains. Previous studies have shown that infants and children living with HIV-1 generate bnAbs more frequen…
View article: Validation of prototype virus inactivation from seven virus families of pandemic potential with a novel low-cost, field-deployable RNA extraction and storage method
Validation of prototype virus inactivation from seven virus families of pandemic potential with a novel low-cost, field-deployable RNA extraction and storage method Open
The Centers for Research in Emerging Infectious Diseases (CREID) was established to enhance pandemic preparedness by studying emerging/reemerging pathogens, especially in resource-limited regions. To overcome infrastructure challenges, a l…
View article: Gene discovery and expression analysis of the B cell receptor repertoire in the domestic ferret model
Gene discovery and expression analysis of the B cell receptor repertoire in the domestic ferret model Open
The domestic ferret is the preferred model organism for the study of influenza A infection and responses to vaccination, because its respiratory tract architecture and sialic acid receptor type and distribution are similar to those in huma…
View article: Analysis of <i>Treponema pallidum</i> subsp. <i>pallidum</i> predicted outer membrane proteins (OMPeomes) in 21 clinical samples: variant sequences are predominantly surface-exposed
Analysis of <i>Treponema pallidum</i> subsp. <i>pallidum</i> predicted outer membrane proteins (OMPeomes) in 21 clinical samples: variant sequences are predominantly surface-exposed Open
The incidence of syphilis, a sexually transmitted disease caused by the Treponema pallidum subsp. pallidum (TPA), has been surging globally despite effective antibiotic therapy. A new strategy for syphilis control is the development of a m…
View article: Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of <i>Treponema pallidum</i> outer membrane proteins
Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of <i>Treponema pallidum</i> outer membrane proteins Open
Knowledge of Treponema pallidum subspecies pallidum ( TPA ) outer membrane protein (OMP) sequence variability is essential for understanding spirochete proliferation within endemic populations as well as the design of a globally effective …
View article: Importance of outbreak response research in bridging knowledge gaps on emerging infectious diseases
Importance of outbreak response research in bridging knowledge gaps on emerging infectious diseases Open
An important outcome of the devastating 2014 West African Ebola virus disease outbreak and the 2020 COVID-19 pandemic has been the growing promotion of conducting research during outbreaks of emerging infectious diseases (EIDs) as a valuab…
View article: SARS-COV-2 MRNA VACCINE IMMUNOGENICITY IN SLE
SARS-COV-2 MRNA VACCINE IMMUNOGENICITY IN SLE Open
PV152 / #774 Poster Topic: AS17 - Miscellaneous Background/Purpose The ACR recommends SARS-CoV-2 vaccination for all patients with rheumatic diseases, but the impact of immune suppressing medications on SARS-CoV-2 immunogenicity remains po…
View article: Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques
Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques Open
Background Sequential multivalent immunizations are used to counter diversity in rapidly mutating viruses. Here, we evaluated the effect of HIV-1 immunogen formats on the binding profile of memory B-cells elicited in two independent Rhesus…
View article: Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of <i>Treponema pallidum</i> outer membrane proteins
Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of <i>Treponema pallidum</i> outer membrane proteins Open
Knowledge of Treponema pallidum subspecies pallidum ( TPA ) outer membrane protein (OMP) sequence variability is essential for understanding spirochete proliferation within endemic populations as well as design of a globally effective syph…
View article: Coinfection with HIV-1 skews iNKT cells toward TCR anergy and limited expansion potential in people with hepatitis C
Coinfection with HIV-1 skews iNKT cells toward TCR anergy and limited expansion potential in people with hepatitis C Open
Introduction Hepatitis C virus (HCV) infection remains a leading cause of morbidity and mortality in people with human immunodeficiency virus (HIV). Liver fibrosis progression is more rapid in people with HIV/HCV coinfection compared to HC…
View article: Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases
Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases Open
The discovery of broadly protective antibodies to the influenza virus neuraminidase (NA) has raised interest in NA as a vaccine target. However, recombinant, solubilized tetrameric NA ectodomains are often challenging to express and isolat…
View article: Use of a pathogen X tabletop exercise to assess the operational response preparedness of an emerging infectious diseases research network
Use of a pathogen X tabletop exercise to assess the operational response preparedness of an emerging infectious diseases research network Open
In mid-2020, the Centers for Research in Emerging Infectious Diseases (CREID) Network was established to address critical gaps in research expertise and capacity in emerging and re-emerging infectious diseases (EIDs). As the Network was es…
View article: Disease diagnostics using machine learning of B cell and T cell receptor sequences
Disease diagnostics using machine learning of B cell and T cell receptor sequences Open
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen exposures encoded by receptors on B cel…
View article: Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases
Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases Open
The discovery of broadly protective antibodies to the influenza virus neuraminidase (NA) has raised interest in NA as a vaccine target. However, recombinant, solubilized tetrameric NA ectodomains are often challenging to express and isolat…
View article: Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities
Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities Open
The global resurgence of syphilis has created a potent stimulus for vaccine development. To identify potentially protective antibodies against Treponema pallidum ( TPA ), we used Pyrococcus furiosus thioredoxin ( Pf Trx) to display extrace…
View article: Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure
Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure Open
It is well established that humoral immunity targeting hepatitis B virus surface antigen (HBsAg) plays a critical role in viral clearance and clinical cure. However, the functional changes in HBsAg-specific B cells before and after achievi…
View article: Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure
Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure Open
It is well established that humoral immunity targeting hepatitis B virus surface antigen (HBsAg) plays a critical role in viral clearance and clinical cure. However, the functional changes in HBsAg-specific B cells before and after achievi…
View article: Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial
Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial Open
For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-…
View article: Spatiotemporal Control of Immune Responses with Nucleic Acid Cocktail Vaccine
Spatiotemporal Control of Immune Responses with Nucleic Acid Cocktail Vaccine Open
Nucleic acid vaccines play important roles in the prevention and treatment of diseases. However, limited immunogenicity remains a major obstacle for DNA vaccine applications in the clinic. To address the issue, the present study investigat…
View article: Impact of Hepatitis B Virus Point-of-care DNA Viral Load Testing Compared With Laboratory-based Standard-of-care Approaches on Uptake of HBV Viral Load Testing, Treatment, and Turnaround Times: A Systematic Review and Meta-analysis
Impact of Hepatitis B Virus Point-of-care DNA Viral Load Testing Compared With Laboratory-based Standard-of-care Approaches on Uptake of HBV Viral Load Testing, Treatment, and Turnaround Times: A Systematic Review and Meta-analysis Open
Background Point-of-care (PoC) hepatitis B virus (HBV) DNA viral load (VL) assays represent an alternative to laboratory-based standard-of-care (SoC) VL assays to accelerate diagnosis and treatment. We evaluated the impact of using PoC ver…
View article: Clinical and genomic diversity of Treponema pallidum subspecies pallidum to inform vaccine research: an international, molecular epidemiology study
Clinical and genomic diversity of Treponema pallidum subspecies pallidum to inform vaccine research: an international, molecular epidemiology study Open
US National Institutes of Health National Institute for Allergy and Infectious Disease, the Bill & Melinda Gates Foundation, Connecticut Children's, and the Czech Republic National Institute of Virology and Bacteriology.
View article: Immunodominant extracellular loops of<i>Treponema pallidum</i>FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities
Immunodominant extracellular loops of<i>Treponema pallidum</i>FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities Open
The global resurgence of syphilis has created a potent stimulus for vaccine development. To identify potentially protective antibodies (Abs) against Treponema pallidum ( TPA ), we used Pyrococcus furiosus thioredoxin ( Pf Trx) to display e…
View article: Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia
Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia Open
Background Venereal syphilis, caused by the spirochete Treponema pallidum subsp. pallidum ( TPA ), is surging worldwide, underscoring the need for a vaccine with global efficacy. Vaccine development requires an understanding of syphilis ep…
View article: Clinical Presentation of Early Syphilis and Genomic Sequences of <i>Treponema pallidum</i> Strains in Patient Specimens and Isolates Obtained by Rabbit Inoculation
Clinical Presentation of Early Syphilis and Genomic Sequences of <i>Treponema pallidum</i> Strains in Patient Specimens and Isolates Obtained by Rabbit Inoculation Open
Background The global resurgence of syphilis necessitates vaccine development. Methods We collected ulcer exudates and blood from 17 participants with primary syphilis (PS) and skin biopsies and blood from 51 patients with secondary syphil…
View article: 901 Cross-sectional analysis of lupus erythematosus and dermatomyositis stress and cardiovascular health (LEADS-CV) data reveals ideal cardiovascular health is rare in affected youth
901 Cross-sectional analysis of lupus erythematosus and dermatomyositis stress and cardiovascular health (LEADS-CV) data reveals ideal cardiovascular health is rare in affected youth Open
Funding This study was supported by the Rheumatology Research Foundation Investigator Award (PI: Ardalan). Disclosures KA – Cure JM Foundation (support for clinical trial design with ReveraGen BioPharma) LES – Bristol Myers Squibb (researc…