Julia Sinclair
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View article: Characteristics of alcohol care teams in England: results of the ProACTIVE National Survey
Characteristics of alcohol care teams in England: results of the ProACTIVE National Survey Open
Aims This study aimed to identify (i) the number of alcohol care teams (ACTs) in England, (ii) the characteristics of patients supported by ACTs, and (iii) the service structure and care components offered by ACTs. Methods All acute hospit…
View article: Exploring the psychosocial needs and nutritional status of older adults with alcohol use disorder: A mixed-methods study (The OLA Study)
Exploring the psychosocial needs and nutritional status of older adults with alcohol use disorder: A mixed-methods study (The OLA Study) Open
Background Alcohol-related hospital admissions are rising in England, particularly among individuals aged 65 and over. While alcohol intake and nutritional status are important factors in health outcomes, they are often overlooked. Lonelin…
View article: Judgments of predictability, preventability and causation of mental health homicides in England 2010 – 2023
Judgments of predictability, preventability and causation of mental health homicides in England 2010 – 2023 Open
Independent mental health homicide inquiries in England are required to comment on predictability and preventability and attribute causation. National commissioning bodies do not provide definitions. This study examines how predictability …
View article: Framework for Brain-Derived Dimensions of Psychopathology
Framework for Brain-Derived Dimensions of Psychopathology Open
Importance Psychiatric diagnoses are not defined by neurobiological measures hindering the development of therapies targeting mechanisms underlying mental illness. Research confined to diagnostic boundaries yields heterogeneous biological …
View article: AUDIT^2 – A Clinical Audit of the Alcohol Assessment and Management in the Southern Gambling Service – First Round Results
AUDIT^2 – A Clinical Audit of the Alcohol Assessment and Management in the Southern Gambling Service – First Round Results Open
Aims: The audit aimed to evaluate assessment, intervention, and signposting for alcohol use problems in people with gambling disorder presenting to the Southern Gambling Service (SGS). Methods: The study included ninety-eight patients refe…
View article: Brain Diffusion Transformer for Personalized Neuroscience and Psychiatry
Brain Diffusion Transformer for Personalized Neuroscience and Psychiatry Open
Task-fMRI analyses typically focus on localized activation contrasts between stimuli, neglecting the brain’s dynamic hierarchy. We introduce Brain Diffusion Transformer (Brain-DiT), a deep generative model capturing recurrent processing un…
View article: Hierarchical Neurocognitive Model of Externalizing and Internalizing Comorbidity
Hierarchical Neurocognitive Model of Externalizing and Internalizing Comorbidity Open
Mounting evidence suggests hierarchical psychopathology factors underlying psychiatric comorbidity. However, the exact neurobiological characterizations of these multilevel factors remain elusive. In this study, leveraging the brain-behavi…
View article: Alcohol use among populations with autism spectrum disorder: narrative systematic review
Alcohol use among populations with autism spectrum disorder: narrative systematic review Open
Background Alcohol use in autism spectrum disorder (ASD) is under-researched. Previous reviews have explored substance use as a whole, but this neglects individual characteristics unique to different substances. Alcohol use in non-clinical…
View article: Multimodal Investigations of Structural and Functional Brain Alterations in Anorexia and Bulimia Nervosa and Their Relationships to Psychopathology
Multimodal Investigations of Structural and Functional Brain Alterations in Anorexia and Bulimia Nervosa and Their Relationships to Psychopathology Open
These findings illuminate key neurobehavioral mechanisms that underlie EDs and point to potential brain-based targets for developing specialized treatment.
View article: Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review
Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review Open
There is a growing literature exploring the placebo response within specific mental disorders, but no overarching quantitative synthesis of this research has analyzed evidence across mental disorders. We carried out an umbrella review of m…
View article: Distinct personality profiles associated with disease risk and diagnostic status in eating disorders
Distinct personality profiles associated with disease risk and diagnostic status in eating disorders Open
The results suggest neuroticism and impulsivity as risk and diagnostic markers for EDs, with neuroticism and hopelessness as shared diagnostic markers. They may inform the design of more personalised prevention and intervention strategies.
View article: A framework for a brain-derived nosology of psychiatric disorders
A framework for a brain-derived nosology of psychiatric disorders Open
Current psychiatric diagnoses are not defined by neurobiological measures which hinders the development of therapies targeting mechanisms underlying mental illness 1,2 . Research confined to diagnostic boundaries yields heterogeneous biolo…
View article: Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy
Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy Open
Brief psychosocial interventions may increase the rate of continuous abstinence among pregnant women who report alcohol use during pregnancy. Further studies should be conducted to investigate the efficacy and safety of psychosocial interv…
View article: Machine learning models for diagnosis and risk prediction in eating disorders, depression, and alcohol use disorder
Machine learning models for diagnosis and risk prediction in eating disorders, depression, and alcohol use disorder Open
This study uses machine learning models to uncover diagnostic and risk prediction markers for eating disorders (EDs), major depressive disorder (MDD), and alcohol use disorder (AUD). Utilizing case-control samples (ages 18-25 years) and a …
View article: RoB2 datasheets
RoB2 datasheets Open
Here, you can find the datasheets used to evaluate the risk of bias of the included studies in the following review: Minozzi S, Ambrosi L, Saulle R, Uhm SS, Terplan M, Sinclair JMA, Agabio R. Psychosocial and medication interventions to st…
View article: Differing impact of the COVID-19 pandemic on youth mental health: combined population and clinical study
Differing impact of the COVID-19 pandemic on youth mental health: combined population and clinical study Open
Background Identifying youths most at risk to COVID-19-related mental illness is essential for the development of effective targeted interventions. Aims To compare trajectories of mental health throughout the pandemic in youth with and wit…
View article: Placebo effects in mental health disorders: protocol for an umbrella review
Placebo effects in mental health disorders: protocol for an umbrella review Open
Introduction Given the high prevalence of mental health disorders and their significant socioeconomic burden, there is a need to develop improved treatments, and to evaluate them through placebo-controlled trials. However, the magnitude of…
View article: Adjunctive Medication Management and Contingency Management to enhance adherence to acamprosate for alcohol dependence: the ADAM trial RCT
Adjunctive Medication Management and Contingency Management to enhance adherence to acamprosate for alcohol dependence: the ADAM trial RCT Open
Background Acamprosate is an effective and cost-effective medication for alcohol relapse prevention but poor adherence can limit its full benefit. Effective interventions to support adherence to acamprosate are therefore needed. Objectives…
View article: Author Correction: A shared neural basis underlying psychiatric comorbidity
Author Correction: A shared neural basis underlying psychiatric comorbidity Open
Correction to: Nature Medicine. Published online 24 April 2023. In the version of this article initially published, the STRATIFY data also included cohort data from the ESTRA consortium, though this was not acknowledged in the author list …
View article: 1586 OLDER AGE IS AN IMPORTANT PREDICTOR OF NON-REFERRAL TO COMMUNITY ALCOHOL SERVICES FOLLOWING AN INPATIENT EPISODE: FINDINGS FROM
1586 OLDER AGE IS AN IMPORTANT PREDICTOR OF NON-REFERRAL TO COMMUNITY ALCOHOL SERVICES FOLLOWING AN INPATIENT EPISODE: FINDINGS FROM Open
Introduction Alcohol use disorder (AUD) in older adults is increasingly common, under-recognised and under-treated within acute hospitals. Methods Consecutive patients seen by the Alcohol Care Team (ACT) at an acute NHS trust between Janua…
View article: Management of medically assisted withdrawal from alcohol in acute adult mental health and specialist addictions in-patient services: UK clinical audit findings
Management of medically assisted withdrawal from alcohol in acute adult mental health and specialist addictions in-patient services: UK clinical audit findings Open
Background Medically assisted alcohol withdrawal (MAAW) is increasingly undertaken on acute adult psychiatric wards. Aims Comparison of the quality of MAAW between acute adult wards and specialist addictions units in mental health services…
View article: Autism and gambling: A systematic review, focusing on neurocognition
Autism and gambling: A systematic review, focusing on neurocognition Open
Autism spectrum disorders (hereafter autism) are prevalent and often associated with elevated rates of substance use disorders. A subset of people who gamble develop gambling disorder, which is functionally impairing. Characterization of r…
View article: RoB2 datasheets
RoB2 datasheets Open
Here, you can find the datasheets used to evaluate the risk of bias of the included studies in the following review: Minozzi S, Ambrosi L, Saulle R, Uhm SS, Terplan M, Sinclair JMA, Agabio R. Psychosocial and medication interventions to st…