Explanipedia

Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies Open

Ilana Lichtenstein, MA Charleston, TS Caetano, Gamble, MA Vadas · 2013

Background The learning active subnetworks problem involves finding subnetworks of a bio-molecular network that are active in a particular condition. Many approaches integrate observation data (e.g., gene expression) with the network topol…

Extracellular truncations of h beta c, the common signaling subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5, lead to ligand-independent activation Open

RJ DAndrea, SC Barry, PA Moretti, Karen L. Jones, Sarah Ellis , et al. · 1996

The hypothesis that extracellular truncation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony- stimulating factor, and IL-5 (h beta c) can lead to ligand-independent activation was tested by infecting …

Chronic expression of P-selectin on endothelial cells stimulated by the T-cell cytokine, interleukin-3 Open

Yeesim Khew‐Goodall, C M Butcher, MS Litwin, Shawn D. Newlands, Eija Korpelainen , et al. · 1996

P-selectin expressed on the surface of endothelium mediates leukocyte adhesion in vitro and rolling in vivo. Several inducers of cell-surface P-selectin expression on endothelial cells (EC) have previously been identified, all of which yie…

Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist Open

Qing‐Yuan Sun, Joanna M. Woodcock, Aaron P. Rapoport, FC Stomski, Eija Korpelainen , et al. · 1996

The human interleukin-3 receptor (IL-3R) is expressed on myeloid, lymphoid, and vascular endothelial cells, where it transduces IL-3- dependent signals leading to cell activation. Although IL-3R activation may play a role in hematopoiesis …

Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist Open

Qing‐Yuan Sun, Joanna M. Woodcock, Aaron P. Rapoport, FC Stomski, Eija Korpelainen , et al. · 1996

The human interleukin-3 receptor (IL-3R) is expressed on myeloid, lymphoid, and vascular endothelial cells, where it transduces IL-3- dependent signals leading to cell activation. Although IL-3R activation may play a role in hematopoiesis …

Regulation of granulocyte-macrophage colony-stimulating factor and E- selectin expression in endothelial cells by cyclosporin A and the T- cell transcription factor NFAT Open

GW Cockerill, Andrew G. Bert, GR Ryan, Jennifer R. Gamble, MA Vadas , et al. · 1995

Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As w…

Regulation of granulocyte-macrophage colony-stimulating factor and E- selectin expression in endothelial cells by cyclosporin A and the T- cell transcription factor NFAT Open

GW Cockerill, Andrew G. Bert, GR Ryan, Jennifer R. Gamble, MA Vadas , et al. · 1995

Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As w…

Interferon-gamma upregulates interleukin-3 (IL-3) receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production Open

Eija Korpelainen, Jennifer R. Gamble, William Smith, Mara Dottore, MA Vadas , et al. · 1995

The human interleukin-3 (IL-3) receptor is constitutively expressed on certain hematopoietic cells where it mediates proliferation and differentiation, or functional activation. We have recently found that human umbilical vein endothelial …

Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor Open

TR Hercus, Bronwyn Cambareri, Mara Dottore, Joanna M. Woodcock, CJ Bagley , et al. · 1994

Residues within the first and fourth helices of human granulocyte- macrophage colony-stimulating factor (hGM-CSF) were analyzed for their role in biologic activity and interaction with the alpha- and beta- chains of the hGM-CSF receptor. W…

Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor Open

TR Hercus, Bronwyn Cambareri, Mara Dottore, Joanna M. Woodcock, CJ Bagley , et al. · 1994

Residues within the first and fourth helices of human granulocyte- macrophage colony-stimulating factor (hGM-CSF) were analyzed for their role in biologic activity and interaction with the alpha- and beta- chains of the hGM-CSF receptor. W…

Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter Open

SM Dunn, LS Coles, RK Lang, Steve Gerondakis, MA Vadas , et al. · 1994

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor produced by mesenchymal and myeloid cells following activation by inflammatory stimuli. It has previously been shown that a region of the G-CSF promoter, (-200 …

A cytokine receptor gene cluster in the X-Y pseudoautosomal region? Open

Eric J. Kremer, Elizabeth Baker, RJ DAndrea, Rima Slim, Hilary A. Phillips , et al. · 1993

The receptors for interleukin-3 (IL-3), IL-5, and granulocyte- macrophage colony-stimulating factor (GM-CSF) are heterodimers comprised of ligand specific alpha chains and a common beta chain. The genes encoding the IL-5 receptor alpha cha…

Inhibition of human monocyte adhesion by interleukin-4 Open

MJ Elliott, Jennifer R. Gamble, LS Park, MA Vadas, Angel F. López · 1991

The adhesion of monocytes to vascular surfaces is central to inflammation and atherogenesis; however, very little is known about regulatory factors that can prevent these processes. Here we report the inhibition of human monocyte adhesion …

Human interleukin-3 mRNA accumulation is controlled at both the transcriptional and posttranscriptional level Open

GR Ryan, SE Milton, Angel F. López, PG Bardy, MA Vadas , et al. · 1991

Interleukin-3 (IL-3) is a hematopoietic growth factor that regulates the differentiation of multilineage and committed progenitor cells and the functions of some mature blood cells. The expression of human IL-3 appears to be restricted to …

Recombinant human interleukin-3 and granulocyte-macrophage colony- stimulating factor show common biological effects and binding characteristics on human monocytes Open

MJ Elliott, MA Vadas, JM Eglinton, LS Park, LB To , et al. · 1989

Two human hemopoietic growth factors involved in monocytopoiesis, interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) were studied for their ability to stimulate blood monocytes and to bind to the monocyte me…

Recombinant human interleukin-3 and granulocyte-macrophage colony- stimulating factor show common biological effects and binding characteristics on human monocytes Open

MJ Elliott, MA Vadas, JM Eglinton, LS Park, LB To , et al. · 1989

Two human hemopoietic growth factors involved in monocytopoiesis, interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) were studied for their ability to stimulate blood monocytes and to bind to the monocyte me…

Recombinant human interleukin-3 stimulation of hematopoiesis in humans: loss of responsiveness with differentiation in the neutrophilic myeloid series Open

Angel F. López, P. Dyson, To Lb, MJ Elliott, SE Milton , et al. · 1988

Recombinant human (rh) interleukin-3 (IL-3) stimulated the proliferation and differentiation of erythroid, granulocyte, macrophage, eosinophil (Eo), and mixed colonies as well as megakaryocytes from human bone marrow cells. rh IL-3 was a w…

Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome Open

GR Sutherland, E Baker, DF Callen, HD Campbell, IG Young , et al. · 1988

Human interleukin-5 (IL-5) is a selective eosinophilopoietic and eosinophil-activating growth hormone. By in situ hybridization this gene is mapped to chromosome 5q23.3 to 5q32. It is shown to be deleted in two patients with the 5q-syndrom…

Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome Open

GR Sutherland, Elizabeth Baker, DF Callen, HD Campbell, IG Young , et al. · 1988

Human interleukin-5 (IL-5) is a selective eosinophilopoietic and eosinophil-activating growth hormone. By in situ hybridization this gene is mapped to chromosome 5q23.3 to 5q32. It is shown to be deleted in two patients with the 5q-syndrom…

Localization of the G-CSF gene on chromosome 17 proximal to the breakpoint in the t(15;17) in acute promyelocytic leukemia Open

RN Simmers, LM Webber, M Shannon, O. Margaret Garson, G Wong , et al. · 1987

The human granulocyte-colony stimulating factor gene (G-CSF) is localized at 17q11.2-q21, the region of one of the breakpoints in the 15;17 chromosome translocation specific for acute promyelocytic leukemia (APL). As G-CSF induces differen…

Localization of the G-CSF gene on chromosome 17 proximal to the breakpoint in the t(15;17) in acute promyelocytic leukemia Open

RN Simmers, LM Webber, M Shannon, O. Margaret Garson, G Wong , et al. · 1987

The human granulocyte-colony stimulating factor gene (G-CSF) is localized at 17q11.2-q21, the region of one of the breakpoints in the 15;17 chromosome translocation specific for acute promyelocytic leukemia (APL). As G-CSF induces differen…

Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: a rapid and sensitive microassay for colony-stimulating factors Open

C. Glenn Begley, Angel F. López, Nicos A. Nicola, DJ Warren, MA Vadas , et al. · 1986

The survival of purified human blood neutrophils and eosinophils was monitored using microwell cultures. Survival was enhanced in cultures containing human or murine colony-stimulating factors (CSFs). The survival of both cell types was en…

Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: a rapid and sensitive microassay for colony-stimulating factors Open

C. Glenn Begley, Angel F. López, Nicos A. Nicola, D. J. Warren, MA Vadas , et al. · 1986

The survival of purified human blood neutrophils and eosinophils was monitored using microwell cultures. Survival was enhanced in cultures containing human or murine colony-stimulating factors (CSFs). The survival of both cell types was en…

Biologic properties in vitro of a recombinant human granulocyte- macrophage colony-stimulating factor Open

D Metcalf, C. Glenn Begley, GR Johnson, Nicos A. Nicola, MA Vadas , et al. · 1986

Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) was purified to homogeneity from medium conditioned by COS cells transfected with a cloned human GM-CSF cDNA and shown to be an effective proliferative stimulus…

Correlation between the stimulation of human neutrophil function by monoclonal antibody and by colony-stimulating factor Open

MA Vadas, C Clarke, Nicos A. Nicola, Angel F. López · 1985

Purified human neutrophils from 48 individuals were tested for their capacity to kill antibody-coated target cells in vitro in the absence or presence of stimulating agents. The agents used to stimulate cytotoxic capacity were the monoclon…

Correlation between the stimulation of human neutrophil function by monoclonal antibody and by colony-stimulating factor Open

MA Vadas, C. Peter Clarke, Nicos A. Nicola, Angel F. López · 1985

Purified human neutrophils from 48 individuals were tested for their capacity to kill antibody-coated target cells in vitro in the absence or presence of stimulating agents. The agents used to stimulate cytotoxic capacity were the monoclon…

The clonal proliferation in vitro of enriched populations of human promyelocytes and myelocytes Open

C. Glenn Begley, Angel F. López, MA Vadas, D Metcalf · 1985

The proliferative capacity of normal human promyelocytes and myelocytes was demonstrated and characterized on the basis of clonal proliferation in agar. An enriched population of normal human promyelocytes and myelocytes was obtained from …

The clonal proliferation in vitro of enriched populations of human promyelocytes and myelocytes Open

C. Glenn Begley, Angel F. López, MA Vadas, Daisy Metcalf · 1985

The proliferative capacity of normal human promyelocytes and myelocytes was demonstrated and characterized on the basis of clonal proliferation in agar. An enriched population of normal human promyelocytes and myelocytes was obtained from …

Eosinophil activation by colony-stimulating factor in man: metabolic effects and analysis by flow cytometry Open

MA Vadas, G Varigos, N Nicola, S Pincus, A Dessein , et al. · 1983

Substantial increases in the killing capacity of human eosinophils after in vitro incubation with human placental conditioned medium (HPCM), a standard source of colony-stimulating factor (CSF), have recently been described. In this articl…

Eosinophil activation by colony-stimulating factor in man: metabolic effects and analysis by flow cytometry Open

MA Vadas, George Varigos, Nicos A. Nicola, S Pincus, Alain Dessein , et al. · 1983

Substantial increases in the killing capacity of human eosinophils after in vitro incubation with human placental conditioned medium (HPCM), a standard source of colony-stimulating factor (CSF), have recently been described. In this articl…

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