Ying Li
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View article: Two-year evolution of frailty status and predictive factors in Chinese older adults: a national longitudinal study
Two-year evolution of frailty status and predictive factors in Chinese older adults: a national longitudinal study Open
Background With the global aging population, frailty in older adults has emerged as a critical focus in health and aging research. As a dynamic and multifactorial process, the transition to frailty is shaped by not only biological factors …
View article: Global, regional, and national burden of brain and other central nervous system cancers from 1990 to 2021, and projections to 2035: a systematic analysis for the global burden of disease study 2021
Global, regional, and national burden of brain and other central nervous system cancers from 1990 to 2021, and projections to 2035: a systematic analysis for the global burden of disease study 2021 Open
Background: The burden of primary brain and other central nervous system (CNS) cancers, collectively termed CNS cancers, has undergone significant changes in recent decades. This study aimed to estimate the burden, trends, and inequalities…
View article: Impact of social vulnerability on frailty transition among older adults in China: a national two-year cohort study
Impact of social vulnerability on frailty transition among older adults in China: a national two-year cohort study Open
Frailty deterioration with age is more common than improvement. Increased social frailty is a significant risk factor for the worsening of frailty, particularly in non-frail and prefrail individuals. Early identification and prevention of …
View article: Luteolin as a multifaceted immunomodulator: insights into its effects on diverse immune cell populations and therapeutic implications
Luteolin as a multifaceted immunomodulator: insights into its effects on diverse immune cell populations and therapeutic implications Open
Luteolin, a natural flavonoid, exerts broad immunomodulatory effects across multiple immune cell populations, positioning it as a promising candidate for treating inflammatory diseases, infections, and cancer. This review synthesizes curre…
View article: Electroacupuncture restores intestinal mucosal barrier in IBS-D rats by modulating mast cell-derived exosomal MiR-149-5p
Electroacupuncture restores intestinal mucosal barrier in IBS-D rats by modulating mast cell-derived exosomal MiR-149-5p Open
Background Intestinal barrier dysfunction is a key etiology of diarrhea-predominant irritable bowel syndrome (IBS-D), and our previous work has demonstrated that mast cells play a critical role in this process. Here, we further show that e…
View article: Piezo knockdown reduces 5‑hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation
Piezo knockdown reduces 5‑hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation Open
Enterochromaffin (EC) cell dysfunction decreases 5‑hydroxytryptamine (5‑HT) secretion, contributing to functional constipation (FC). However, the underlying mechanisms remain unclear. Piezo ion channels mediate 5‑HT release from EC cells. …
View article: Association Between Anti-Inflammatory Diet, Dietary Diversity, and Depressive Symptoms Among Chinese Pregnant Women
Association Between Anti-Inflammatory Diet, Dietary Diversity, and Depressive Symptoms Among Chinese Pregnant Women Open
Background: Dietary inflammatory potential and dietary diversity during pregnancy may program depression, yet these associations remain poorly characterized. This study aimed to assess an anti-inflammatory diet and dietary diversity in rel…
View article: AZD5153 enhances the chemo-sensitivity of gemcitabine on pancreatic cancer cells in vitro and in vivo
AZD5153 enhances the chemo-sensitivity of gemcitabine on pancreatic cancer cells in vitro and in vivo Open
Background Pancreatic cancer is a malignant disease with a poor prognosis. Gemcitabine (GEM), the first-line treatment drug, shows limited efficacy because of the notorious drug resistance of pancreatic cancer. Therefore, the development o…
View article: Clinical characteristics and the risk factors of patients with chronic kidney disease in young-onset versus late-onset newly diagnosed type 2 diabetes
Clinical characteristics and the risk factors of patients with chronic kidney disease in young-onset versus late-onset newly diagnosed type 2 diabetes Open
Background The association between young-onset diabetes and chronic kidney disease has been well studied, however, few studies have described the features of chronic kidney disease (CKD) specifically in young-onset diabetes. We aimed to co…
View article: Case Report: Omalizumab-associated hair loss: a case of eyebrow alopecia areata, literature review and FAERS database analysis
Case Report: Omalizumab-associated hair loss: a case of eyebrow alopecia areata, literature review and FAERS database analysis Open
Hair loss is a rare adverse reaction associated with omalizumab, with limited literature reports. The incidence, underlying mechanisms, and clinical characteristics of omalizumab-associated hair loss have not been clarified. We report a 52…
View article: Sleep prevents brain phosphoproteome disruption to safeguard survival
Sleep prevents brain phosphoproteome disruption to safeguard survival Open
Prolonged sleep deprivation (Pr-SD) causes death in many species. While various mechanisms related to sleep regulation or this fatal consequence of sleep loss have been identified, the core molecular basis linking Pr-SD-induced lethality a…
View article: [Clinical characteristics of epilepsy with intellectual disability associated with <i>SETD1B</i> gene in three pediatric cases and a literature review].
[Clinical characteristics of epilepsy with intellectual disability associated with <i>SETD1B</i> gene in three pediatric cases and a literature review]. Open
The primary phenotypes associated with SETD1B gene variants are intellectual disability and seizures, and seizures exhibit distinct characteristics. Eyelid myoclonia is not uncommon.
View article: Circ_0001715 Mediated Progression and Inflammation in Fibroblast‐Like Synoviocytes of Rheumatoid Arthritis by Targeting miR‐326/TLR‐4‐NF‐κB Pathway
Circ_0001715 Mediated Progression and Inflammation in Fibroblast‐Like Synoviocytes of Rheumatoid Arthritis by Targeting miR‐326/TLR‐4‐NF‐κB Pathway Open
Rheumatoid arthritis (RA) is a systemic autoimmune disease. Circular RNA_0001715 (circ_0001715) has been demonstrated to be involved in the progression of cancers. This study aimed to discuss the function of circ_0001715 on the development…
View article: Comprehensive genomic analysis of genetic diversity, body size, and origins of the Hetian Gray donkey
Comprehensive genomic analysis of genetic diversity, body size, and origins of the Hetian Gray donkey Open
In summary, the results confirm that geographical distance plays a crucial role in determining the genetic relationships among the Hetian Gray donkey and other populations. The Xinjiang donkey and the Guanzhong donkey played an important r…
View article: Oscillator Gene OsRVE6a Coordinates Multi-Level Defense Mechanisms against Small Brown Planthopper in Rice
Oscillator Gene OsRVE6a Coordinates Multi-Level Defense Mechanisms against Small Brown Planthopper in Rice Open
Pest and disease outbreaks are considerable threats to global food security. Salicylic acid (SA) and jasmonic acid (JA) are key defense hormones that play crucial roles in plant resistance to biotic stresses. However, the mechanism by whic…
View article: Dynamic Syntactic Feature Filtering and Injecting Networks for Cross-lingual Dependency Parsing
Dynamic Syntactic Feature Filtering and Injecting Networks for Cross-lingual Dependency Parsing Open
Pre-trained language models enhanced parsers have achieved outstanding performance in rich-resource languages. Cross-lingual dependency parsing aims to learn useful knowledge from high-resource languages to alleviate data scarcity in low-r…
View article: Sanshen San Formula Hinders Cognitive Function and Pathology in Alzheimer's Disease Through Potentiating the Function of Synapse
Sanshen San Formula Hinders Cognitive Function and Pathology in Alzheimer's Disease Through Potentiating the Function of Synapse Open
Background Alzheimer's disease ( AD ) constitutes a devastating neurodegenerative disorder, manifested by amyloid‐β aggregation, phosphorylated tau accumulation, and progressive cognitive deterioration. Current therapeutic interventions re…
View article: Dietary fiber from burdock root ameliorates functional constipation in aging rats by regulating intestinal motility
Dietary fiber from burdock root ameliorates functional constipation in aging rats by regulating intestinal motility Open
Functional constipation is a common gastrointestinal health issue among the aging population. Dietary fiber supplementation is widely recognized as a first-line strategy for constipation. However, the effectiveness of dietary fiber in prac…
View article: Mizoribine or Cyclophosphamide for Lupus Nephritis
Mizoribine or Cyclophosphamide for Lupus Nephritis Open
Importance Lupus nephritis is typically treated with intravenous cyclophosphamide, which is associated with serious adverse effects. Oral mizoribine may be an alternative for induction therapy of lupus nephritis. However, large-scale, long…