Maaike R. Scheenstra
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View article: S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration
S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration Open
Chronic infection with Schistosoma mansoni parasites is associated with reduced allergic sensitization in humans, while schistosome eggs protects against allergic airway inflammation (AAI) in mice. One of the main secretory/excretory molec…
View article: Schistosoma mansoni egg-derived thioredoxin and Sm14 drive the development of IL-10 producing regulatory B cells
Schistosoma mansoni egg-derived thioredoxin and Sm14 drive the development of IL-10 producing regulatory B cells Open
During chronic schistosome infections, a complex regulatory network is induced to regulate the host immune system, in which IL-10-producing regulatory B (Breg) cells play a significant role. Schistosoma mansoni soluble egg antigens (SEA) a…
View article: Innate Immune Training of Human Macrophages by Cathelicidin Analogs
Innate Immune Training of Human Macrophages by Cathelicidin Analogs Open
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against…
View article: The cathelicidin CATH-2 efficiently neutralizes LPS- and E. coli-induced activation of porcine bone marrow derived macrophages
The cathelicidin CATH-2 efficiently neutralizes LPS- and E. coli-induced activation of porcine bone marrow derived macrophages Open
View article: d-enantiomers of CATH-2 enhance the response of macrophages against Streptococcus suis serotype 2
d-enantiomers of CATH-2 enhance the response of macrophages against Streptococcus suis serotype 2 Open
View article: The immunomodulatory effect of cathelicidin-B1 on chicken macrophages
The immunomodulatory effect of cathelicidin-B1 on chicken macrophages Open
View article: Cathelicidins Modulate TLR-Activation and Inflammation
Cathelicidins Modulate TLR-Activation and Inflammation Open
Cathelicidins are short cationic peptides that are part of the innate immune system. At first, these peptides were studied mostly for their direct antimicrobial killing capacity, but nowadays they are more and more appreciated for their im…
View article: Chicken CATH-2 Increases Antigen Presentation Markers on Chicken Monocytes and Macrophages
Chicken CATH-2 Increases Antigen Presentation Markers on Chicken Monocytes and Macrophages Open
Background: Cathelicidins are a family of Host Defense Peptides (HDPs), that play an important role in the innate immune response. They exert both broad-spectrum antimicrobial activity against pathogens, and strong immunomodulatory functio…
View article: Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action
Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action Open
Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimicrobial activity, also important immunomodulatory functions. Bacteria are less likely to develop resistance against HDPs because these pepti…
View article: A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages
A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages Open
Porcine M1- and M2-polarized macrophages can be most efficiently cultured from mononuclear bone marrow cells using porcine GM-CSF and murine M-CSF. The new culture method facilitates more refined studies of porcine macrophages in vitro, im…
View article: Studies on Gata1 and PU.1 in dendritic cells: Mice are not human
Studies on Gata1 and PU.1 in dendritic cells: Mice are not human Open
View article: Cathelicidins Inhibit <i>Escherichia coli</i>–Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner
Cathelicidins Inhibit <i>Escherichia coli</i>–Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner Open
Activation of the immune system needs to be tightly regulated to provide protection against infections and, at the same time, to prevent excessive inflammation to limit collateral damage to the host. This tight regulation includes regulati…
View article: A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence
A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence Open
View article: Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis
Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis Open
View article: Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment
Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment Open
During hematopoiesis, transcriptional programs are essential for the commitment and differentiation of progenitors into the different blood lineages. GATA1 is a transcription factor expressed in several hematopoietic lineages and essential…