Maarten Coemans
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View article: Continuous indices to assess the phenotypic spectrum of kidney transplant rejection
Continuous indices to assess the phenotypic spectrum of kidney transplant rejection Open
The Banff classification for kidney transplant pathology dichotomizes the rejection continuum into distinct diagnostic categories, introducing artificial cutoff points and threshold effects. To better reflect the underlying disease spectru…
View article: Socioeconomic Deprivation and Kidney Transplant Outcomes
Socioeconomic Deprivation and Kidney Transplant Outcomes Open
View article: Impact of Solvent-Accessible HLA Amino Acid Mismatches on Kidney Transplant Outcomes: A Multicenter Longitudinal Study
Impact of Solvent-Accessible HLA Amino Acid Mismatches on Kidney Transplant Outcomes: A Multicenter Longitudinal Study Open
Current alloimmune risk assessment in kidney transplantation relies on HLA antigen mismatches, lacking precision for individualized care. In contrast, solvent-accessible HLA amino acid (saAA) mismatches, empirically defined across all HLA …
View article: Maximum cold ischemia duration for a kidney allograft: a prediction model for allograft failure at the time of organ allocation
Maximum cold ischemia duration for a kidney allograft: a prediction model for allograft failure at the time of organ allocation Open
View article: Evolution in peak oxygen uptake and its impact on physical activities of daily living in chronic kidney disease and transplantation
Evolution in peak oxygen uptake and its impact on physical activities of daily living in chronic kidney disease and transplantation Open
This viewpoint aims to characterise the evolution of peak oxygen uptake (V̇O 2 peak) in chronic kidney disease (CKD), describe its impact on patients’ ability to engage in physical activities of daily living and frame the meaningfulness of …
View article: <i>FCGR3A</i>F158V Genotype Accelerates Progression to Chronic Alloimmune Injury in Antibody-Mediated Kidney Transplant Rejection: A Population-Based Cohort Study
<i>FCGR3A</i>F158V Genotype Accelerates Progression to Chronic Alloimmune Injury in Antibody-Mediated Kidney Transplant Rejection: A Population-Based Cohort Study Open
Background Evidence for involvement of NK cells and monocytes as prime agents in the process of human kidney transplant rejection is expanding quickly. These cells express FCGR3A, used for antibody-dependent cellular cytotoxicity (ADCC) af…
View article: Primary FSGS is not associated with worse kidney outcome compared with other FSGS subtypes
Primary FSGS is not associated with worse kidney outcome compared with other FSGS subtypes Open
Background Studies that compare kidney outcomes across patients with different forms of focal segmental glomerulosclerosis (FSGS) are lacking. Methods This retrospective study compared annual estimated glomerular filtration rate (eGFR) slo…
View article: Maximum Cold Ischemia Duration for a Kidney Allograft a Prediction Model for Allograft Failure at the Time of Organ Allocation
Maximum Cold Ischemia Duration for a Kidney Allograft a Prediction Model for Allograft Failure at the Time of Organ Allocation Open
View article: Continuous indices to assess the phenotypic spectrum of kidney transplant rejection
Continuous indices to assess the phenotypic spectrum of kidney transplant rejection Open
The international Banff classification for kidney transplant pathology discretizes the rejection continuum into distinct diagnostic categories, introducing artificial dichotomization and threshold effects. To better reflect the underlying …
View article: An observational cohort study examined the change point of kidney function stabilization in the initial period after transplantation
An observational cohort study examined the change point of kidney function stabilization in the initial period after transplantation Open
Baseline kidney function following kidney transplantation is often used in research and clinical decision-making yet is not well defined. Here, a method to determine baseline function was proposed and validated on three single-center retro…
View article: The impact of competing risks in kidney allograft failure prediction
The impact of competing risks in kidney allograft failure prediction Open
Background Prognostic models are becoming increasingly relevant in clinical trials as potential surrogate endpoints, and for patient management as clinical decision support tools. However, the impact of competing risks on model performance…
View article: Are exceptions justified in the current heart allocation system?
Are exceptions justified in the current heart allocation system? Open
Based on waitlist mortality over a longer study period than previous analyses, high-priority exceptions are appropriately placed in the current heart allocation system. The current allocation system requires a large fraction of candidates …
View article: Table of Contents
Table of Contents Open
View article: Automated Urinary Chemokine Assays for Noninvasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study
Automated Urinary Chemokine Assays for Noninvasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study Open
Urinary chemokines CXCL9 and CXCL10 have been suggested to be good noninvasive biomarkers of kidney transplant rejection. However, defining a context of use and integration with clinical information is necessary before clinical implementat…
View article: An observational cohort study of histological screening for BK polyomavirus nephropathy following viral replication in plasma
An observational cohort study of histological screening for BK polyomavirus nephropathy following viral replication in plasma Open
View article: Leukopenia in autosomal dominant polycystic kidney disease: a single-center cohort of kidney transplant candidates with post-transplantation follow-up
Leukopenia in autosomal dominant polycystic kidney disease: a single-center cohort of kidney transplant candidates with post-transplantation follow-up Open
Background Autosomal dominant polycystic kidney disease (ADPKD) has occasionally been associated with lower peripheral white blood cell (WBC) counts. This study aimed to investigate the peripheral blood cell counts in a large cohort of kid…
View article: Bias by censoring for competing events in survival analysis
Bias by censoring for competing events in survival analysis Open
In survival analysis, competing events preclude the occurrence of the event of interest. The censoring of competing events is common in medical studies but leads to biased cumulative incidence estimators. Competing risks methods, such as t…
View article: Association of Predicted HLA T-Cell Epitope Targets and T-Cell–Mediated Rejection After Kidney Transplantation
Association of Predicted HLA T-Cell Epitope Targets and T-Cell–Mediated Rejection After Kidney Transplantation Open
View article: Association of HLA Mismatches and Histology Suggestive of Antibody-Mediated Injury in the Absence of Donor-Specific Anti-HLA Antibodies
Association of HLA Mismatches and Histology Suggestive of Antibody-Mediated Injury in the Absence of Donor-Specific Anti-HLA Antibodies Open
Background and objectives The histology of antibody-mediated rejection after kidney transplantation is observed frequently in the absence of detectable donor-specific anti-HLA antibodies. Although there is an active interest in the role of…
View article: Circulating Donor-Specific Anti-HLA Antibodies Associate With Immune Activation Independent of Kidney Transplant Histopathological Findings
Circulating Donor-Specific Anti-HLA Antibodies Associate With Immune Activation Independent of Kidney Transplant Histopathological Findings Open
Despite the critical role of cytokines in allograft rejection, the relation of peripheral blood cytokine profiles to clinical kidney transplant rejection has not been fully elucidated. We assessed 28 cytokines through multiplex assay in 29…
View article: Forecasting of Patient-Specific Kidney Transplant Function With a Sequence-to-Sequence Deep Learning Model
Forecasting of Patient-Specific Kidney Transplant Function With a Sequence-to-Sequence Deep Learning Model Open
In this diagnostic study, a sequence-to-sequence deep learning model was developed and validated for individual forecasting of kidney transplant function. The patient-specific sequence predictions could be used in clinical practice to guid…
View article: Missing Self–Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study
Missing Self–Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study Open
Significance Statement Microvascular inflammation (MVI) of the kidney transplant is an important determinant of allograft outcome. Although MVI is considered a cardinal manifestation of antibody-mediated rejection, it is often encountered …
View article: Risk factors, histopathological features, and graft outcome of transplant glomerulopathy in the absence of donor-specific HLA antibodies
Risk factors, histopathological features, and graft outcome of transplant glomerulopathy in the absence of donor-specific HLA antibodies Open
Transplant glomerulopathy is established as a hallmark of chronic antibody-mediated rejection in kidney transplant patients with donor-specific HLA antibodies (HLA-DSA). The clinical importance of transplant glomerulopathy in the absence o…
View article: Revisiting the changes in the Banff classification for antibody-mediated rejection after kidney transplantation
Revisiting the changes in the Banff classification for antibody-mediated rejection after kidney transplantation Open
View article: The Histological Picture of Indication Biopsies in the First 2 Weeks after Kidney Transplantation
The Histological Picture of Indication Biopsies in the First 2 Weeks after Kidney Transplantation Open
Background and objectives In preclinical studies, ischemia-reperfusion injury and older donor age are associated with graft inflammation in the early phase after transplantation. In human kidney transplantation, impaired allograft function…
View article: Eplet Mismatch Load and De Novo Occurrence of Donor-Specific Anti-HLA Antibodies, Rejection, and Graft Failure after Kidney Transplantation: An Observational Cohort Study
Eplet Mismatch Load and De Novo Occurrence of Donor-Specific Anti-HLA Antibodies, Rejection, and Graft Failure after Kidney Transplantation: An Observational Cohort Study Open
Significance Statement HLA matching for three HLA loci (HLA-A, HLA-B, and HLA-DR) at a low-resolution antigen level has been integral to algorithms for allocating donor kidneys for transplant since the 1970s. The authors used high-resoluti…
View article: Clinical importance of extended second field high-resolution HLA genotyping for kidney transplantation
Clinical importance of extended second field high-resolution HLA genotyping for kidney transplantation Open
The need for extended second field high-resolution (2F-HR) HLA genotyping in kidney transplantation is debated. In a cohort of 1000 kidney transplants, we evaluated the impact of different HLA genotyping levels on the assignment of donor-s…
View article: Effect of donor nephrectomy time during circulatory-dead donor kidney retrieval on transplant graft failure
Effect of donor nephrectomy time during circulatory-dead donor kidney retrieval on transplant graft failure Open
Background When the blood supply ceases in a deceased organ donor, ischaemic injury starts. Kidneys are cooled to reduce cellular metabolism and minimize ischaemic injury. This cooling is slow and kidneys are lukewarm during nephrectomy. S…
View article: Development and validation of a peripheral blood mRNA assay for the assessment of antibody-mediated kidney allograft rejection: A multicentre, prospective study
Development and validation of a peripheral blood mRNA assay for the assessment of antibody-mediated kidney allograft rejection: A multicentre, prospective study Open
The Seventh Framework Programme (FP7) of the European Commission.
View article: FP787DONOR NEPHRECTOMY TIME DURING CIRCULATORY-DEAD DONOR KIDNEY RETRIEVAL ASSOCIATES WITH GRAFT FAILURE AFTER TRANSPLANTATION
FP787DONOR NEPHRECTOMY TIME DURING CIRCULATORY-DEAD DONOR KIDNEY RETRIEVAL ASSOCIATES WITH GRAFT FAILURE AFTER TRANSPLANTATION Open
old and acute kidney disease.At the last stage, we select 79 patients who strated on dialysis but had an early FCN.This method estimate a potential of 228 PTX in pediatrics patients in France between 2010 and 2016.Worth mentioning, despite…