Maarten Jaspers
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View article: Process intensification using a semi-continuous mini-blender to support continuous direct compression processing
Process intensification using a semi-continuous mini-blender to support continuous direct compression processing Open
The production of pharmaceutical tablets is shifting towards continuous manufacturing. Therefore, individual unit operations such as powder blending need to be re-designed. Continuous powder blending has been implemented successfully, but …
View article: Modeling the Impact of Excipients Selection on Nitrosamine Formation towards Risk Mitigation
Modeling the Impact of Excipients Selection on Nitrosamine Formation towards Risk Mitigation Open
Risk control for nitrosamine impurities in drug products is currently a major challenge in the industry. Nitrosamines can form during drug product manufacturing and storage through the reaction of nitrites with amine-containing APIs or imp…
View article: Recent developments in lactose blend formulations for carrier-based dry powder inhalation
Recent developments in lactose blend formulations for carrier-based dry powder inhalation Open
Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI) formulations. Numerous inhalation therapies have been developed using lactose as a carrier material. Several theories have described the role of carri…
View article: A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants
A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants Open
Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the inherent…
View article: Impact of excipients on batch and continuous powder blending
Impact of excipients on batch and continuous powder blending Open
Stimulated by Pharma 4.0, the pharmaceutical industry is changing from batch-wise to continuous manufacturing. Therefore, individual processing steps such as blending of the active pharmaceutical ingredient (API) with excipients have to be…
View article: Nonlinear mechanics of hybrid polymer networks that mimic the complex mechanical environment of cells
Nonlinear mechanics of hybrid polymer networks that mimic the complex mechanical environment of cells Open
The mechanical properties of cells and the extracellular environment they reside in are governed by a complex interplay of biopolymers. These biopolymers, which possess a wide range of stiffnesses, self-assemble into fibrous composite netw…
View article: Mechanics and Structure of Strain Stiffening Biomimetic Hydrogels
Mechanics and Structure of Strain Stiffening Biomimetic Hydrogels Open
Cells in the human body show a large increase in stiffness when subjected to an external force, comparable to stretching a rubber band. This phenomena is known as strain stiffening and prevents natural cells and tissues from breaking when …
View article: Bundle Formation in Biomimetic Hydrogels
Bundle Formation in Biomimetic Hydrogels Open
Bundling of single polymer chains is a crucial process in the formation of biopolymer network gels that make up the extracellular matrix and the cytoskeleton. This bundled architecture leads to gels with distinctive properties, including a…
View article: Fibrin-fiber architecture influences cell spreading and differentiation
Fibrin-fiber architecture influences cell spreading and differentiation Open
The mechanical and structural properties of the extracellular matrix (ECM) play an important role in regulating cell fate. The natural ECM has a complex fibrillar structure and shows nonlinear mechanical properties, which are both difficul…
View article: Critical behaviour in the nonlinear elastic response of hydrogels
Critical behaviour in the nonlinear elastic response of hydrogels Open
In this paper we study the elastic response of synthetic hydrogels to an applied shear stress. The hydrogels studied here have previously been shown to mimic the behaviour of biopolymer networks when they are sufficiently far above the gel…