Maarten Mennes
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View article: Default mode network integrity across neuropsychiatric disorders and its relation to social dysfunction: A normative modelling approach
Default mode network integrity across neuropsychiatric disorders and its relation to social dysfunction: A normative modelling approach Open
Structural and functional default mode network (DMN) alterations are common in neuropsychiatric disorders and may contribute transdiagnostically to social dysfunction. Normative modelling enables assessment of DMN alterations at the indivi…
View article: Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study
Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study Open
Background Sensory processing requires selectivity to salient sensory input. Many autistic individuals report different sensory processing, which has been associated with altered sensory selectivity. The locus-coeruleus norepinephrine (LC-…
View article: Social dysfunction relates to altered default mode network functional integrity across neuropsychiatric disorders: A replication and generalization study
Social dysfunction relates to altered default mode network functional integrity across neuropsychiatric disorders: A replication and generalization study Open
Background Social dysfunction is an early manifestation of neuropsychiatric disorders that may relate to altered Default Mode Network (DMN) integrity. This study aimed to replicate previous findings linking social dysfunction with diminish…
View article: Correction: Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study
Correction: Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study Open
View article: Multiscale heterogeneity of functional connectivity in autism
Multiscale heterogeneity of functional connectivity in autism Open
Atypical functional connectivity (FC) in autism is a common finding, but the results of individual studies are often inconsistent and sometimes contradictory. Classical reliance on case-control comparisons of group means that ignore the in…
View article: Patterns of Brain Maturation in Autism and Their Molecular Associations
Patterns of Brain Maturation in Autism and Their Molecular Associations Open
Importance In the neurotypical brain, regions develop in coordinated patterns, providing a fundamental scaffold for brain function and behavior. Whether altered patterns contribute to clinical profiles in neurodevelopmental conditions, inc…
View article: Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study
Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study Open
View article: Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortex
Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortex Open
Neuroimaging studies have identified the anterior cingulate cortex (ACC) as one of the major targets of ketamine in the human brain, which may be related to ketamine’s antidepressant (AD) mechanisms of action. However, due to different met…
View article: Digital behavioural signatures reveal trans-diagnostic clusters of Schizophrenia and Alzheimer's disease patients
Digital behavioural signatures reveal trans-diagnostic clusters of Schizophrenia and Alzheimer's disease patients Open
View article: The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings
The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings Open
Background Autism spectrum disorders (ASD) are neurodevelopmental conditions accompanied by differences in brain development. Neuroanatomical differences in autism are variable across individuals and likely underpin distinct clinical pheno…
View article: Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study
Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study Open
View article: Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring
Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring Open
View article: Differences in Intrinsic Gray Matter Connectivity and Their Genomic Underpinnings in Autism Spectrum Disorder
Differences in Intrinsic Gray Matter Connectivity and Their Genomic Underpinnings in Autism Spectrum Disorder Open
Based on intrinsic gray matter connectivity, the current study investigated the complex neuroanatomy of autism and linked between-group differences to putative genomic and/or molecular mechanisms to parse the heterogeneity of autism and pr…
View article: Region- and time- specific effects of ketamine on cerebral blood flow: a randomized controlled trial
Region- and time- specific effects of ketamine on cerebral blood flow: a randomized controlled trial Open
View article: Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case–control study
Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case–control study Open
View article: Supplementary Material for: Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain
Supplementary Material for: Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain Open
Introduction: Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion i…
View article: Effects of ketamine and lamotrigine on negative emotional processing in the brain: a double-blind randomized controlled neuroimaging study
Effects of ketamine and lamotrigine on negative emotional processing in the brain: a double-blind randomized controlled neuroimaging study Open
View article: Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain
Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain Open
Introduction: Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion interaction sin…
View article: Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project
Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project Open
View article: Connectome-wide Mega-analysis Reveals Robust Patterns of Atypical Functional Connectivity in Autism
Connectome-wide Mega-analysis Reveals Robust Patterns of Atypical Functional Connectivity in Autism Open
The FC alterations observed, which primarily involve hypoconnectivity of primary sensory and attention networks and hyperconnectivity of the default mode network and subcortex with the rest of the brain, do not appear to be age or sex depe…
View article: Closing the life-cycle of normative modeling using federated hierarchical Bayesian regression
Closing the life-cycle of normative modeling using federated hierarchical Bayesian regression Open
Clinical neuroimaging data availability has grown substantially in the last decade, providing the potential for studying heterogeneity in clinical cohorts on a previously unprecedented scale. Normative modeling is an emerging statistical t…
View article: The Link Between Autism and Sex-Related Neuroanatomy, and Associated Cognition and Gene Expression
The Link Between Autism and Sex-Related Neuroanatomy, and Associated Cognition and Gene Expression Open
OBJECTIVE: The male preponderance in prevalence of autism is among the most pronounced sex ratios across neurodevelopmental conditions. The authors sought to elucidate the relationship between autism and typical sex-differential neuroanato…
View article: The effects of transient receptor potential cation channel inhibition by BI 1358894 on cortico-limbic brain reactivity to negative emotional stimuli in major depressive disorder
The effects of transient receptor potential cation channel inhibition by BI 1358894 on cortico-limbic brain reactivity to negative emotional stimuli in major depressive disorder Open
Abnormal emotional processing in major depressive disorder (MDD) has been associated with increased activation to negative stimuli in cortico-limbic brain regions. The authors investigated whether treatment with BI 1358894, a small-molecul…
View article: Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology
Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology Open
View article: Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring
Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring Open
Background. The connectome, constituting a unique fingerprint of a person’s brain, may be influenced by its prenatal environment, potentially affecting later-life resilience and mental health. Methods. We conducted a prospective resting-st…
View article: Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis
Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis Open
View article: Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior
Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior Open
View article: The link between autism and sex-specific neuroanatomy, and associated cognition and gene expression
The link between autism and sex-specific neuroanatomy, and associated cognition and gene expression Open
Objectives The male preponderance in autism spectrum conditions (ASC) prevalence is among the most pronounced sex ratios across different neurodevelopmental conditions. Here, we aimed to elucidate the relationship between autism and typica…
View article: Connectome-wide mega-analysis reveals robust patterns of atypical functional connectivity in autism
Connectome-wide mega-analysis reveals robust patterns of atypical functional connectivity in autism Open
Neuroimaging studies on functional connectivity (FC) in autism have been hampered by small sample sizes and inconsistent findings with regard to whether connectivity is increased or decreased in individuals with autism, whether these alter…
View article: Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers
Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers Open