Maartje J. Hooning
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View article: Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women
Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women Open
Background: Breast cancer polygenic risk scores (PRS) and traditional risk models (e.g., the Gail model [Gail]) are known to contribute largely independent information, but it is unclear how the overlap varies by ancestry, age, disease typ…
View article: Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer
Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer Open
View article: Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on bone mineral density
Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on bone mineral density Open
The pre-registered clinical trial number is < NCT03835793 > .
View article: Supplemental Table 6 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Table 6 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplemental Table 6 includes a sensitivity analysis to determine changes in mammographic density in women who underwent a risk-reducing salpingo-oophorectomy compared to women who did not undergo RRSO in the interval between mammograms, r…
View article: Supplemental Table 5 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Table 5 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplemental Table 5 includes changes in total breast area among women with a pathogenic germline variant in BRCA1 or BRCA2 who did or did not undergo risk-reducing salpingo-oophorectomy in the interval between mammograms
View article: Supplemental Table 7 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Table 7 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplemental Table 7 includes analysis of changes in mammographic density in women with pathogenic germline variant in BRCA1 who underwent a risk-reducing salpingo-oophorectomy (RRSO) compared to women with a pathogenic germline variant in…
View article: Supplemental Table 1 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Table 1 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplemental Table 1 includes the descriptive statistics of the 2356 BRCA1 or BRCA2 carriers in the IBCCS consortium who had any available mammograms prior to selection and inclusion in the current study
View article: Supplemental Table 8 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Table 8 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplemental Table 8 includes analysis of changes in mammographic density in women with pathogenic germline variant in BRCA2 who underwent a risk-reducing salpingo-oophorectomy (RRSO) compared to women with a pathogenic germline variant in…
View article: Supplemental Figure 2 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Figure 2 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplemental Figure 2 shows a cross-tabulation of pseudo BI-RADS classification of breast density at first and second mammograms in women with a pathogenic germline variant in BRCA1 or BRCA2 who did not undergo risk-reducing salpingo-oopho…
View article: Supplemental Table 3 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Table 3 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplementary Table 3 includes the descriptive statistics of the women with a pathogenic germline variant in BRCA2 with or without risk-reducing salpingo-oophorectomy who were included in the study analysis (N=290)
View article: Data from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Data from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Background:We studied changes in mammographic density (MD) among premenopausal women with a pathogenic germline variant (PGV) in the BRCA1 or BRCA2 gene, comparing those who did and did not undergo risk-reducing salpingo-ooph…
View article: Supplemental Figure 1 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Figure 1 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplemental Figure 1 shows a cross-tabulation of pseudo BI-RADS classification of breast density before and after a risk-reducing salpingo-oophorectomy (RRSO) in women with pathogenic germline variant in BRCA1 or BRCA2
View article: Supplemental Table 4 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Table 4 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplementary Table 4 includes the median density and change in mammographic density country per view and per country
View article: Supplemental Table 2 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Supplemental Table 2 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Supplementary Table 2 includes the descriptive statistics of the women with a pathogenic germline variant in BRCA1 with or without risk-reducing salpingo-oophorectomy who were included in the study analysis (N=401)
View article: Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>
Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i> Open
Background: We studied changes in mammographic density (MD) among premenopausal women with a pathogenic germline variant (PGV) in the BRCA1 or BRCA2 gene, comparing those who did and did not undergo risk-reducing salpingo-oophorectomy (RRS…
View article: Coronary Artery Calcium Scores After Prophylactic Premenopausal Bilateral Salpingo-Oophorectomy
Coronary Artery Calcium Scores After Prophylactic Premenopausal Bilateral Salpingo-Oophorectomy Open
View article: Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset
Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset Open
View article: The impact of baseline health factors on second primary cancer risk after radiotherapy for prostate cancer
The impact of baseline health factors on second primary cancer risk after radiotherapy for prostate cancer Open
Purpose: In evaluating second primary cancers (SPCs) following External Beam Radiotherapy (EBRT), the role of lifestyle factors is frequently not considered due to data limitations. We investigated the association between smoking, comorbid…
View article: Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families
Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families Open
View article: The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families
The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families Open
To determine the changes in surveillance category by adding a polygenic risk score based on 311 breast cancer (BC)-associated variants (PRS311), questionnaire-based risk factors and breast density on personalized BC risk in unaffected wome…
View article: Erratum to ‘The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families’ [The Breast 73 (2024) 103611]
Erratum to ‘The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families’ [The Breast 73 (2024) 103611] Open
View article: Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk
Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk Open
Background Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of BRCA1 / BRCA2 (CIMBA), …
View article: Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction
Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction Open
The 313-variant polygenic risk score (PRS 313 ) provides a promising tool for breast cancer risk prediction. However, evaluation of the PRS 313 across different European populations which could influence risk estimation has not been perfor…
View article: Expression and Localization of Ferritin-Heavy Chain Predicts Recurrence for Breast Cancer Patients with a BRCA1/2 Mutation
Expression and Localization of Ferritin-Heavy Chain Predicts Recurrence for Breast Cancer Patients with a BRCA1/2 Mutation Open
The ferritin-heavy chain (FTH1) is the catalytic subunit of the ferroxidase ferritin, which prevents oxidative DNA damage via intracellular iron storage. FTH1 was shown to be a prognostic marker for triple-negative breast cancer (BC) patie…
View article: The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families
The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families Open
View article: The effect of (neo)adjuvant chemotherapy on long‐term survival outcomes in patients with invasive lobular breast cancer treated with endocrine therapy: A retrospective cohort study
The effect of (neo)adjuvant chemotherapy on long‐term survival outcomes in patients with invasive lobular breast cancer treated with endocrine therapy: A retrospective cohort study Open
Background Despite histological and molecular differences between invasive lobular carcinoma (ILC) and invasive carcinoma of no special type, according to national treatment guidelines no distinction is made regarding the use of (neo)adjuv…
View article: Urinary incontinence more than 15 years after premenopausal risk‐reducing salpingo‐oophorectomy: a multicentre cross‐sectional study
Urinary incontinence more than 15 years after premenopausal risk‐reducing salpingo‐oophorectomy: a multicentre cross‐sectional study Open
Objective To study the impact of premenopausal risk‐reducing salpingo‐oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) ≥10 years later. Design Cross‐sectional study, nested in a nationwide cohort. Settin…
View article: Contralateral breast cancer risk in patients with breast cancer and a germline-<i>BRCA1/2</i> pathogenic variant undergoing radiation
Contralateral breast cancer risk in patients with breast cancer and a germline-<i>BRCA1/2</i> pathogenic variant undergoing radiation Open
Background Radiation-induced secondary breast cancer (BC) may be a concern after radiation therapy (RT) for primary breast cancer (PBC), especially in young patients with germline (g)BRCA–associated BC who already have high contralateral B…
View article: Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases
Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases Open
FANCM germline protein truncating variants (PTVs) are moderate-risk factors for ER-negative breast cancer. We previously described the spectrum of FANCM PTVs in 114 European breast cancer cases. In the present, larger cohort, we report the…
View article: PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants
PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants Open