Explanipedia

Molecular detection and isolation of clade Ib monkeypox virus, Canada, November 2024 Open

Mable Chan, Jonathan Audet, Jérémie Prévost, Karla Soriano, Kaylie Doan , et al. · 2025

In November 2024, a case of clade Ib mpox was confirmed in Canada. Here, we describe the events that led to laboratory confirmation of clade Ib monkeypox virus (MPXV) and the public health response. Genomic analysis of the Canadian clade I…

Mucosal Vaccination with a Newcastle Disease Virus-Vectored Vaccine Reduces Viral Loads in SARS-CoV-2-Infected Cynomolgus Macaques Open

Bryce M. Warner, Mable Chan, Nikesh Tailor, Robert Vendramelli, Jonathan Audet , et al. · 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged following an outbreak of unexplained viral illness in China in late 2019. Since then, it has spread globally causing a pandemic that has resulted in millions of deaths an…

Detection of Mpox Virus in Wastewater Provides Fore-Warning of Clinical Cases in Canadian Cities Open

Edgard M. Mejia, Nikho A. Hizon, Codey Dueck, Ravinder Lidder, Jade Daigle , et al. · 2024

Extracellular vesicle storm during the course of Ebola virus infection in primates Open

Andrea Vucetic, Andrea Lafleur, Marceline Côté, Darwyn Kobasa, Mable Chan , et al. · 2023

Introduction Ebola virus (EBOV) is an RNA virus of the Filoviridae family that is responsible for outbreaks of hemorrhagic fevers in primates with a lethality rate as high as 90%. EBOV primarily targets host macrophages leading to cell act…

Sphingosine Kinases Promote Ebola Virus Infection and Can Be Targeted to Inhibit Filoviruses, Coronaviruses, and Arenaviruses Using Late Endocytic Trafficking to Enter Cells Open

Corina M. Stewart, Yuxia Bo, Kathy Fu, Mable Chan, Robert Kozak , et al. · 2023

Entry of enveloped viruses in host cells requires the fusion of viral and host cell membranes, a process that is facilitated by viral fusion proteins protruding from the viral envelope. These viral fusion proteins need to be triggered by h…

An Outbred Guinea Pig Disease Model for Lassa Fever Using a Host-Adapted Clade III Nigerian Lassa Virus Open

Yvon Deschambault, Geoff Soule, Levi Klassen, Angela Sloan, Jonathan Audet , et al. · 2023

Nigeria experiences annual outbreaks of Lassa fever (LF) with high case numbers. At least three clades of Lassa virus (LASV) have been documented in Nigeria, though recent outbreaks are most often associated with clade II or clade III viru…

Exploration of wastewater surveillance for Monkeypox virus Open

Edgard M. Mejia, Nikho Hizon, Codey Dueck, Ravinder Lidder, Jade Daigle , et al. · 2022

The sudden emergence and spread of Monkeypox in non-endemic parts of the world is currently not well understood. Infections are often mis-diagnosed and surveillance strategies are scarce. Wastewater-based surveillance (WBS) of human Monkey…

Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells Open

Corina M. Stewart, Yuxia Bo, Kathy Fu, Mable Chan, Robert Kozak , et al. · 2022

Entry of enveloped viruses in host cells requires the fusion of the viral and host cell membranes, a process that is facilitated by viral fusion proteins protruding from the viral envelope. For fusion, viral fusion proteins need to be trig…

Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques Open

Mable Chan, Meenakshi Tiwary, Helen L. Wu, Nikesh Tailor, Robert Vendramelli , et al. · 2022

The world remains at risk of an influenza pandemic, and the development of new therapeutic and preventative modalities is critically important for minimizing human death and suffering during the next influenza pandemic. Animal models are c…

Host parameters and mode of infection influence outcome in SARS-CoV-2-infected hamsters Open

Bryan D. Griffin, Bryce M. Warner, Mable Chan, Emelissa J. Valcourt, Nikesh Tailor , et al. · 2021

Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease Open

Bryce M. Warner, Lisa A. Santry, Alexander Leacy, Mable Chan, Phuc H. Pham , et al. · 2021

The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Ne…

SARS-CoV-2 infection and transmission in the North American deer mouse Open

Bryan D. Griffin, Mable Chan, Nikesh Tailor, Emelissa J. Mendoza, Anders Leung , et al. · 2021

Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection Open

Bryan D. Griffin, Bryce M. Warner, Mable Chan, Emelissa J. Mendoza, Nikesh Tailor , et al. · 2021

The emergence of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resultant pandemic of coronavirus disease 2019 (COVID-19) has led to over one hundred million confirmed infections, greater than three million deaths, an…

Simulated sunlight decreases the viability of SARS-CoV-2 in mucus Open

Angela Sloan, Todd Cutts, Bryan D. Griffin, Samantha Kasloff, Zachary Schiffman , et al. · 2021

The novel coronavirus, SARS-CoV-2, has spread into a pandemic since its emergence in Wuhan, China in December of 2019. This has been facilitated by its high transmissibility within the human population and its ability to remain viable on i…

Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry Open

Zhujun Ao, Mable Chan, Maggie Jing Ouyang, Titus Abiola Olukitibi, Mona Mahmoudi , et al. · 2021

Until now, antiviral therapeutic agents are still urgently required for treatment or prevention of SARS-coronavirus 2 (SCoV-2) virus infection. In this study, we established a sensitive SCoV-2 Spike glycoprotein (SP), including an SP mutan…

A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens Open

E. Gary, Bryce M. Warner, Elizabeth M. Parzych, Bryan D. Griffin, Xizhou Zhu , et al. · 2021

Author Index Open

I. Abaasah, Camille Abadie, Abdul Rahim, Ahmad Bin, Natalie Abramov , et al. · 2021

Characterization of Ebola Virus Risk to Bedside Providers in an Intensive Care Environment Open

Mia J. Biondi, Lauren Garnett, Alexander Bello, Duane J. Funk, Philippe Guillaume Poliquin , et al. · 2021

Background: The 2014–2016 Ebola outbreak in West Africa recapitulated that nosocomial spread of Ebola virus could occur and that health care workers were at particular risk including notable cases in Europe and North America. These instanc…

Simulated Sunlight Decreases the Viability of SARS-CoV-2 in Mucus Open

Angela Sloan, Todd Cutts, Bryan D. Griffin, Samantha Kasloff, Zachary Schiffman , et al. · 2020

This study examined the effect of simulated sunlight on the viability of SARS-CoV-2 spiked into tissue culture medium or mucus. The study revealed that inactivation took 37 minutes in medium and 107 minutes in mucus. These times-to-inactiv…

North American deer mice are susceptible to SARS-CoV-2 Open

Bryan D. Griffin, Mable Chan, Nikesh Tailor, Emelissa J. Mendoza, Anders Leung , et al. · 2020

The zoonotic spillover of the pandemic SARS-coronavirus 2 (SARS-CoV-2) from an animal reservoir, currently presumed to be the Chinese horseshoe bat, into a naïve human population has rapidly resulted in a significant global public health e…

Simulated sunlight decreases the viability of SARS-CoV-2 Open

Angela Sloan, Todd Cutts, Bryan D. Griffin, Samantha Kasloff, Zachary Schiffman , et al. · 2020

The novel coronavirus, SARS-CoV-2, has spread into a pandemic since its emergence in Wuhan, China in December of 2019. This has been facilitated by its high transmissibility within the human population and its ability to remain viable on i…

H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice Open

Mable Chan, Anders Leung, Tamiko Hisanaga, Bradley Pickering, Bryan D. Griffin , et al. · 2020

Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly patho…

<i>Prunella vulgaris</i> Extract Blocks SARS- <i>Coronavirus 2</i> Virus Spike Protein D614 and G614 Variants Mediated Receptor Binding and Virus Entry Open

Zhujun Ao, Mable Chan, Maggie Jing Ouyang, Titus Abiola Olukitibi, Mona Mahmoudi , et al. · 2020

Correction to: Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model Open

Guillaume Poliquin, Duane J. Funk, Shane Jones, Kaylie N. Tran, Charlene Ranadheera , et al. · 2019

Generation and Characterization of a Mouse-Adapted Makona Variant of Ebola Virus Open

Mable Chan, Anders Leung, Bryan D. Griffin, Robert Vendramelli, Nikesh Tailor , et al. · 2019

Ebola virus (EBOV) is a zoonotic pathogen that poses a significant threat to public health, causing sporadic yet devastating outbreaks that have the potential to spread worldwide, as demonstrated during the 2013–2016 West African outbreak.…

Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model Open

Guillaume Poliquin, Duane J. Funk, Shane Jones, Kaylie N. Tran, Charlene Ranadheera , et al. · 2019

Establishment of an RNA polymerase II-driven reverse genetics system for Nipah virus strains from Malaysia and Bangladesh Open

Bryan D. Griffin, Anders Leung, Mable Chan, Bryce M. Warner, Charlene Ranadheera , et al. · 2019

Efficacy of Ebola Glycoprotein-Specific Equine Polyclonal Antibody Product Against Lethal Ebola Virus Infection in Guinea Pigs Open

Mable Chan, Frederick W. Holtsberg, Hong Vu, Katie A. Howell, Anders Leung , et al. · 2018

This study showed that equine-derived polyclonal antibodies are efficacious against lethal EBOV disease in a relevant animal model. Furthermore, the studies support the utility of the equine antibody platform for the rapid production of a …

Intensive Supportive Care Alone Does Not Impact Survival in a Lethal Non-Human Primate Model of Ebola Virus Disease Open

Guillaume Poliquin, Duane J. Funk, Shane Jones, Kaylie N. Tran, Charlene Ranadheera , et al. · 2018

DNA vaccination protects mice against Zika virus-induced damage to the testes Open

Bryan D. Griffin, Kar Muthumani, Bryce M. Warner, Anna Majer, Mable Chan , et al. · 2017

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