Maciej Florczyk
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View article: Transcriptomic Analysis of Biofilm Formation Inhibition by PDIA Iminosugar in Staphylococcus aureus
Transcriptomic Analysis of Biofilm Formation Inhibition by PDIA Iminosugar in Staphylococcus aureus Open
Background: Iminosugars are natural or synthetic sugar analogues with a very broad spectrum of activities, including those against the most prominent bacterial pathogens, like P. aeruginosa or S. aureus. In a series of studies, we have dem…
View article: Transcriptomic Analysis of Biofilm Formation Inhibition by Pdia Iminosugar in <em>Staphylococcus aureus</em>
Transcriptomic Analysis of Biofilm Formation Inhibition by Pdia Iminosugar in <em>Staphylococcus aureus</em> Open
Background: Iminosugars are natural or synthetic sugar analogues with a very broad spectrum of activities including these against most prominent bacterial pathogens like P. aeruginosa or S. aureus. In a series of studies, we have demonstra…
View article: Biopolymer Production in a Full-Scale Activated Sludge Wastewater Treatment Plant: Seasonal Changes and Promising Bacterial Producers
Biopolymer Production in a Full-Scale Activated Sludge Wastewater Treatment Plant: Seasonal Changes and Promising Bacterial Producers Open
Wastewater treatment plants (WWTPs) offer the possibility of recovering valuable substances produced by microorganisms, such as extracellular polymeric substances (EPSs). This study aimed to investigate the generation and properties of bio…
View article: Comparison of Three DNA Extraction Kits for Assessment of Bacterial Diversity in Activated Sludge, Biofilm, and Anaerobic Digestate
Comparison of Three DNA Extraction Kits for Assessment of Bacterial Diversity in Activated Sludge, Biofilm, and Anaerobic Digestate Open
Direct DNA analysis is the most widely used approach for microorganism characterization in natural and built environments; therefore, reliable and effective methods of nucleic acid extraction for samples from particular types of environmen…
View article: Biological Activity and Stability of Aeruginosamides from Cyanobacteria
Biological Activity and Stability of Aeruginosamides from Cyanobacteria Open
Aeruginosamides (AEGs) are classified as cyanobactins, ribosomally synthesized peptides with post-translational modifications. They have been identified in cyanobacteria of genera Microcystis, Oscillatoria, and Limnoraphis. In this work, t…
View article: De Novo Profiling of Long Non-Coding RNAs Involved in MC-LR-Induced Liver Injury in Whitefish: Discovery and Perspectives
De Novo Profiling of Long Non-Coding RNAs Involved in MC-LR-Induced Liver Injury in Whitefish: Discovery and Perspectives Open
Microcystin-LR (MC-LR) is a potent hepatotoxin for which a substantial gap in knowledge persists regarding the underlying molecular mechanisms of liver toxicity and injury. Although long non-coding RNAs (lncRNAs) have been extensively stud…
View article: De novo profiling of long non-coding RNAs involved in MC-LR–induced liver injury in whitefish: discovery and perspectives
De novo profiling of long non-coding RNAs involved in MC-LR–induced liver injury in whitefish: discovery and perspectives Open
BackgroundMicrocystin-LR (MC-LR) is a potent hepatotoxin for which a substantial gap in knowledge persists regarding the underlying molecular mechanisms of liver toxicity and injury. Although long non-coding RNAs (lncRNAs) have been extens…
View article: Luciferase reporter assay for small-molecule inhibitors of MIR92b-3p function: Screening cyanopeptolins produced by Nostoc from the Baltic Sea
Luciferase reporter assay for small-molecule inhibitors of MIR92b-3p function: Screening cyanopeptolins produced by Nostoc from the Baltic Sea Open
We developed a cell sensor that detects the liver cancer-specific microRNA MIR92b-3p, involved in hepatocellular carcinoma development and hepatitis C virus infection. To validate our small-molecule screen that employs a Huh7 human hepatom…
View article: <i>In vivo</i> miRNA delivery in whitefish: Synthetic MiR92b-3p uptake and the efficacy of gene expression silencing
<i>In vivo</i> miRNA delivery in whitefish: Synthetic MiR92b-3p uptake and the efficacy of gene expression silencing Open
Here, we provide the first report of an efficient method of in vivo delivery of MiRNA92b-3p mimic by intraperitoneal injection to whitefish, a Teleost fish. Juvenile whitefish were exposed to synthetic MiR92b-3p suspended in Invivofectamin…
View article: Exploring Baltic Sea cyanobacteria for small-molecule inhibitors of microRNA function: a project description
Exploring Baltic Sea cyanobacteria for small-molecule inhibitors of microRNA function: a project description Open
Environmental Biotechnology deals with preservation and restoration of fauna, flora, and their environment.The utilisation of environmental biotechnology has significantly affected the world and will be one of the most valuable tools for i…
View article: Illumina Sequencing Reveals Aberrant Expression of MicroRNAs and Their Variants in Whitefish (Coregonus lavaretus) Liver after Exposure to Microcystin-LR
Illumina Sequencing Reveals Aberrant Expression of MicroRNAs and Their Variants in Whitefish (Coregonus lavaretus) Liver after Exposure to Microcystin-LR Open
Molecular analyses show that challenging fish with microcystin-LR (MC-LR) causes perturbations of microRNA (miRNA) signaling. However, the significance and scope of these alterations is currently unknown. To address this issue, we studied …
View article: Functional investigation of MiR92b 3p for diagnosis and miRNA based cure in chemically induced liver injury in fish: a project description
Functional investigation of MiR92b 3p for diagnosis and miRNA based cure in chemically induced liver injury in fish: a project description Open
Environmental Biotechnology deals with preservation and restoration of fauna, flora, and their environment.The utilisation of environmental biotechnology has significantly affected the world and will be one of the most valuable tools for i…