Maciej Krzakowski
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View article: PACIFIC-5: a phase III clinical trial of consolidation durvalumab in patients with unresectable stage III NSCLC and no progression after concurrent or sequential chemoradiotherapy
PACIFIC-5: a phase III clinical trial of consolidation durvalumab in patients with unresectable stage III NSCLC and no progression after concurrent or sequential chemoradiotherapy Open
NCT03706690.
View article: Radiation Recall Pneumonitis with Pneumocystis jirovecii Superinfection and Treatment Induced Hyponatremia in a Patient with Non-Small-Cell Lung Cancer
Radiation Recall Pneumonitis with Pneumocystis jirovecii Superinfection and Treatment Induced Hyponatremia in a Patient with Non-Small-Cell Lung Cancer Open
Immune checkpoint inhibitors (ICIs) and thoracic radiotherapy are standard treatments for advanced non-small-cell lung cancer (NSCLC), especially in patients with high PD-L1 expression or symptoms such as superior vena cava syndrome (SVCS)…
View article: Best Practices and Communication Strategies for Informing Oncology Patients About Treatment Discontinuation and Transition to Palliative Care—A Practical Guide for Oncologists
Best Practices and Communication Strategies for Informing Oncology Patients About Treatment Discontinuation and Transition to Palliative Care—A Practical Guide for Oncologists Open
Discontinuing active oncological treatment and initiating palliative care is a critical moment in cancer care, requiring oncologists to address complex clinical, ethical, and emotional challenges. This narrative review aims to provide clin…
View article: Granulocyte colony-stimulating factor in supportive treatment in oncology and hematology
Granulocyte colony-stimulating factor in supportive treatment in oncology and hematology Open
View article: Anticoagulant therapy in patients with cancer and thrombocytopenia
Anticoagulant therapy in patients with cancer and thrombocytopenia Open
Cancer and its treatment predispose to thromboembolic complications and thrombocytopenia. Thrombocytopenia does not protect against thromboembolism, but increases the risk of bleeding. The prognosis in venous thromboembolism (VTE) strictly…
View article: AB017. Clinicopathologic features, treatment outcomes, and survival in thymic neuroendocrine tumors: a 25-year single-center experience
AB017. Clinicopathologic features, treatment outcomes, and survival in thymic neuroendocrine tumors: a 25-year single-center experience Open
View article: Outcomes and prognostic insights in primary tracheal cancer: a multicenter retrospective study
Outcomes and prognostic insights in primary tracheal cancer: a multicenter retrospective study Open
Female sex, good performance status, and absence of nodal metastases were favorable prognostic factors. Radical treatment significantly improved outcomes, emphasizing the importance of early diagnosis and multidisciplinary management. Furt…
View article: Cemiplimab in monotherapy and in combination with chemotherapy for patients with non-small cell lung cancer according to an actual drug program for the treatment of lung cancer and pleural mesothelioma
Cemiplimab in monotherapy and in combination with chemotherapy for patients with non-small cell lung cancer according to an actual drug program for the treatment of lung cancer and pleural mesothelioma Open
View article: Decoding the immune landscape: KRAS and STK11 genes mutations shape CD8+ T cell response in resectable non-small-cell lung cancer after neoadjuvant therapy
Decoding the immune landscape: KRAS and STK11 genes mutations shape CD8+ T cell response in resectable non-small-cell lung cancer after neoadjuvant therapy Open
View article: How to prepare and navigate patients for successful perioperative treatment of non-small-cell lung cancer?
How to prepare and navigate patients for successful perioperative treatment of non-small-cell lung cancer? Open
View article: Recent Clinical and Molecular Advances in the Management of Thymic Carcinoids: A Comprehensive Review
Recent Clinical and Molecular Advances in the Management of Thymic Carcinoids: A Comprehensive Review Open
Background: Thymic carcinoids are rare neuroendocrine tumors arising in the anterior mediastinum, often diagnosed at an advanced stage due to nonspecific clinical manifestations. Their management remains challenging because of the paucity …
View article: The Impact of Implementing Indicators of Quality of Oncological Care on Improving Patient Outcomes: A Cross-Sectional Review of Experiences from Countries Using Indicators in the Quality Assessment Process
The Impact of Implementing Indicators of Quality of Oncological Care on Improving Patient Outcomes: A Cross-Sectional Review of Experiences from Countries Using Indicators in the Quality Assessment Process Open
The implementation of QIs in the pursuit of improving patient outcomes in oncological care has become a primary goal for many countries. The purpose of this cross-sectional review is to present the experiences of several countries that hav…
View article: Effectiveness of First-Line Treatment with Anaplastic Lymphoma Kinase and ROS1 Protoncogene Inhibitors in Non-Small Cell Lung Cancer Patients—Real-World Evidence of Two Polish Cancer Centers
Effectiveness of First-Line Treatment with Anaplastic Lymphoma Kinase and ROS1 Protoncogene Inhibitors in Non-Small Cell Lung Cancer Patients—Real-World Evidence of Two Polish Cancer Centers Open
Introduction: The use of ALK (anaplastic lymphoma kinase) and ROS1 (ROS1 protoncogene) inhibitors are the standard of care in advanced non-small-cell lung cancer (NSCLC) patients with ALK or ROS1 gene rearrangements (approximately 5.5% of …
View article: Fusion variants of the ALK gene — the key to modern therapy for patients with ALK-positive non-small-cell lung cancer
Fusion variants of the ALK gene — the key to modern therapy for patients with ALK-positive non-small-cell lung cancer Open
View article: Ivosidenib in treatment of patients with cholangiocarcinoma with IDH1 mutation — real-world data from a multicenter study
Ivosidenib in treatment of patients with cholangiocarcinoma with IDH1 mutation — real-world data from a multicenter study Open
Pomimo znacznego postępu, jaki nastąpił w ostatnich latach w leczeniu chorych na nowotwory, rak dróg żółciowych, szczególnie w stadium zaawansowanym, pozostaje w dalszym ciągu chorobą o złym rokowaniu. Wydaje się, że zastosowanie nowoczesn…
View article: Prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in second-line immunotherapy for patients with non-small cell lung cancer
Prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in second-line immunotherapy for patients with non-small cell lung cancer Open
Inflammatory indices derived from peripheral blood cells-NLR and PLR-can help assess the prognosis of patients receiving immunotherapy. They also appear to be independent prognostic factors with regard to for PFS and OS.
View article: Optimization of systemic treatment in patients with bladder, ureter, and renal pelvis cancer — expert opinion of the Polish Society of Clinical Oncology
Optimization of systemic treatment in patients with bladder, ureter, and renal pelvis cancer — expert opinion of the Polish Society of Clinical Oncology Open
View article: Recommendations of the Expert Panel and the Polish Lung Cancer Study Group on the use of chemotherapy in combination with osimertinib for treatment of non-small cell lung cancer patients with pathogenic variants of the EGFR gene
Recommendations of the Expert Panel and the Polish Lung Cancer Study Group on the use of chemotherapy in combination with osimertinib for treatment of non-small cell lung cancer patients with pathogenic variants of the EGFR gene Open
View article: Emerging insights into STK11, KEAP1 and KRAS mutations: implications for immunotherapy in patients with advanced non-small cell lung cancer
Emerging insights into STK11, KEAP1 and KRAS mutations: implications for immunotherapy in patients with advanced non-small cell lung cancer Open
Immune checkpoint inhibitors (ICIs) have become an established treatment option for patients with advanced non-small cell lung cancer (NSCLC). However, the efficacy of single-agent immunotherapy as well as in combination with chemotherapy …
View article: Venous thromboembolism is associated with increased all-cause mortality in ALK-positive non-small cell lung cancer
Venous thromboembolism is associated with increased all-cause mortality in ALK-positive non-small cell lung cancer Open
View article: The Detailed Analysis of Polish Patients with Non-Small Cell Lung Cancer Through Insights from Molecular Testing (POL-MOL Study)
The Detailed Analysis of Polish Patients with Non-Small Cell Lung Cancer Through Insights from Molecular Testing (POL-MOL Study) Open
Molecular testing is recommended in patients with metastatic non-small cell lung cancer (NSCLC), but the extent of its use in Poland is unknown. The aim of the POL-MOL study was to investigate the frequency of using molecular testing in Po…
View article: Tracheal Tumors: Clinical Practice Guidelines for Palliative Treatment and Follow-Up
Tracheal Tumors: Clinical Practice Guidelines for Palliative Treatment and Follow-Up Open
A substantial portion of patients with advanced cancer cannot be cured, regardless of the therapeutic methods employed. Hence, rational palliative causal treatment becomes crucial. Representative studies specifically addressing the exclusi…
View article: Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature
Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature Open
Pulmonary benign metastasizing leiomyoma (PBML) is a rare condition characterized by the spread of uterine leiomyomas to the lungs, typically observed in premenopausal women with a history of hysterectomy or myomectomy. This report present…
View article: Pembrolizumab monotherapy survival benefits in metastatic non-small-cell lung cancer: a systematic review of real-world data
Pembrolizumab monotherapy survival benefits in metastatic non-small-cell lung cancer: a systematic review of real-world data Open
View article: Microbial and Metabolic Gut Profiling across Seven Malignancies Identifies Fecal Faecalibacillus intestinalis and Formic Acid as Commonly Altered in Cancer Patients
Microbial and Metabolic Gut Profiling across Seven Malignancies Identifies Fecal Faecalibacillus intestinalis and Formic Acid as Commonly Altered in Cancer Patients Open
The key association between gut dysbiosis and cancer is already known. Here, we used whole-genome shotgun sequencing (WGS) and gas chromatography/mass spectrometry (GC/MS) to conduct metagenomic and metabolomic analyses to identify common …
View article: Treatment outcomes of patients with primary tracheal tumors - analysis of a large retrospective series
Treatment outcomes of patients with primary tracheal tumors - analysis of a large retrospective series Open
Objective Primary tracheal tumors are very rare and their management is not definitely established. Due to its rarity, providing patient care in terms of optimal management poses a considerable challenge. The purpose of this study was to i…
View article: Commentary on Diagnostics and treatment of BRCA-associated cancers with olaparib — expert position statement
Commentary on Diagnostics and treatment of BRCA-associated cancers with olaparib — expert position statement Open
Commentary on Diagnostics and treatment of BRCA-associated cancers with olaparib -expert position statementProteins encoded by the suppressor genes BRCA1 and BRCA2 play an essential role in repairing DNA damage.Reducing or inhibiting the a…
View article: The combination of osimertinib and savolitinib as molecular inhibition of EGFR and MET receptors may be selected to provide maximum effectiveness and acceptable toxicity
The combination of osimertinib and savolitinib as molecular inhibition of EGFR and MET receptors may be selected to provide maximum effectiveness and acceptable toxicity Open
View article: Rechallenge of immunotherapy in non-small cell lung cancer patients — navigating indications and evolving perspectives
Rechallenge of immunotherapy in non-small cell lung cancer patients — navigating indications and evolving perspectives Open
Indications for immunotherapy in patients with non-small-cell lung cancer (NSCLC) are expanding, with an increasing number of patients receiving immunotherapy in the perioperative setting or as consolidation of radiochemotherapy. Immune ch…
View article: Clinicopathological characteristics of patients with primary tracheal tumors: Analysis of eighty‐nine cases
Clinicopathological characteristics of patients with primary tracheal tumors: Analysis of eighty‐nine cases Open
Background Primary tracheal tumors are very rare and the literature on this subject is limited. The most common histological type of primary tracheal tumors is squamous cell carcinoma (SCC), followed by adenoid cystic carcinoma (ACC). Limi…