Maciej Pelak
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View article: Patient-reported outcomes, neurocognitive functioning and oncologic results of pencil-beam-scanning proton beam therapy for CNS WHO G2 and G3 IDH1-mutant diffuse adult glioma: A single institution experience
Patient-reported outcomes, neurocognitive functioning and oncologic results of pencil-beam-scanning proton beam therapy for CNS WHO G2 and G3 IDH1-mutant diffuse adult glioma: A single institution experience Open
Proton therapy is a safe and effective treatment for IDH1/2-mutant diffuse glioma with no apparent detrimental effect on QoL and neurocognitive functioning in this prospective cohort.
View article: P09.03.B ONCOLOGIC AND PATIENT-REPORTED OUTCOMES OF PENCIL-BEAM-SCANNING PROTON BEAM THERAPY FOR CNS WHO G2 AND G3 IDH1-MUTANT GLIOMA: A SINGLE INSTITUTION EXPERIENCE
P09.03.B ONCOLOGIC AND PATIENT-REPORTED OUTCOMES OF PENCIL-BEAM-SCANNING PROTON BEAM THERAPY FOR CNS WHO G2 AND G3 IDH1-MUTANT GLIOMA: A SINGLE INSTITUTION EXPERIENCE Open
BACKGROUND Patients with CNS-WHO G2 and G3 IDH-mutant glioma commonly achieve long survival after chemoradiotherapy. Proton beam therapy (PBT) can be used for this group to reduce the dose to uninvolved brain and, consequently, late toxici…
View article: Carbon-Ion Radiotherapy for Head and Neck Mucosal Melanoma: Preliminary Clinical Outcomes and the MedAustron Approach for Reporting RBE-Weighted Dose With 2 Models
Carbon-Ion Radiotherapy for Head and Neck Mucosal Melanoma: Preliminary Clinical Outcomes and the MedAustron Approach for Reporting RBE-Weighted Dose With 2 Models Open
Bi-RBE model (LEM-I, mMKM) optimized CIRT protocol improved dose comparability of plans between different systems. It also improved intratumoral LETd distribution and resulted in rapid tumor regression, favorable toxicity profile, and exce…
View article: The Value of PET/CT in Particle Therapy Planning of Various Tumors with SSTR2 Receptor Expression: Comparative Interobserver Study
The Value of PET/CT in Particle Therapy Planning of Various Tumors with SSTR2 Receptor Expression: Comparative Interobserver Study Open
The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor …
View article: Carbon Ion radiotherapy for bulky pelvic sarcoma: The MedAustron experience
Carbon Ion radiotherapy for bulky pelvic sarcoma: The MedAustron experience Open
View article: Carbon Ion radiotherapy for head and neck tumors: The MedAustron experience
Carbon Ion radiotherapy for head and neck tumors: The MedAustron experience Open
View article: Prospective Analysis of Radiation-Induced Contrast Enhancement and Health-Related Quality of Life After Proton Therapy for Central Nervous System and Skull Base Tumors
Prospective Analysis of Radiation-Induced Contrast Enhancement and Health-Related Quality of Life After Proton Therapy for Central Nervous System and Skull Base Tumors Open
The overall incidence of clinically relevant RICE after PBT is very low and has no significant negative effect on long-term patient QoL.
View article: P18.09.A PROTON THERAPY FOR PATIENTS WITH MENINGIOMA - WHAT ABOUT FINANCIAL TOXICITY AND OCCUPATIONAL STATUS?
P18.09.A PROTON THERAPY FOR PATIENTS WITH MENINGIOMA - WHAT ABOUT FINANCIAL TOXICITY AND OCCUPATIONAL STATUS? Open
BACKGROUND Patients (pts) with meningioma are commonly treated with proton therapy (PT) in order to minimize integral dose to normal brain parenchyma. Considering the high local control probability, preservation of Quality of Life (QoL) is…
View article: P07.10.A CLINICAL OUTCOMES OF SPOT-SCANNING PROTON BEAM THERAPY FOR IDH-MUTANT CNS WHO GRADE 2 AND 3 GLIOMA
P07.10.A CLINICAL OUTCOMES OF SPOT-SCANNING PROTON BEAM THERAPY FOR IDH-MUTANT CNS WHO GRADE 2 AND 3 GLIOMA Open
BACKGROUND The latest WHO brain tumour classification puts utmost emphasis on prognostic significance of isocitrate dehydrogenase (IDH) mutation. IDH-wildtype tumours are now automatically considered CNS WHO grade 4 and associated with poo…
View article: Proton or Carbon Ion Therapy for Skull Base Chordoma: Rationale and First Analysis of a Mono-Institutional Experience
Proton or Carbon Ion Therapy for Skull Base Chordoma: Rationale and First Analysis of a Mono-Institutional Experience Open
Background: Skull base chordomas are radio-resistant tumors that require high-dose, high-precision radiotherapy, as can be delivered by particle therapy (protons and carbon ions). We performed a first clinical outcome analysis of particle …
View article: P03.06.B Proton irradiation (PT) for benign meningiomas, Grade I clinical experience of the first 100 patients from REGI-MA-002015
P03.06.B Proton irradiation (PT) for benign meningiomas, Grade I clinical experience of the first 100 patients from REGI-MA-002015 Open
Background Meningiomas are the most common CNS tumors and the majority is regarded as benign. However, a subset of patients presents with complex tumors involving several anatomic compartments of the skull base - eluding any concepts of gr…
View article: JS09.6.A Low incidence of radiation-induced brain lesions and stable QoL following proton irradiation for CNS and Skull Base tumors- results from the prospective MedAustron register REGI-MA-002015
JS09.6.A Low incidence of radiation-induced brain lesions and stable QoL following proton irradiation for CNS and Skull Base tumors- results from the prospective MedAustron register REGI-MA-002015 Open
Background Irradiation of intracranial tumors may induce endothelial damage in the surrounding normal brain tissues, resulting in an increase of capillary permeability. These changes can be depicted on magnetic resonance imaging (MRI) as a…
View article: Normofractionated and moderately hypofractionated proton therapy: comparison of acute toxicity and early quality of life outcomes
Normofractionated and moderately hypofractionated proton therapy: comparison of acute toxicity and early quality of life outcomes Open
Aim Data on the safety of moderately hypofractionated proton beam therapy (PBT) are limited. The aim of this study is to compare the acute toxicity and early quality of life (QoL) outcomes of normofractionated (nPBT) and hypofractionated P…
View article: The Value of SSTR2 Receptor-Targeted PET/CT in Proton Irradiation of Grade I Meningioma
The Value of SSTR2 Receptor-Targeted PET/CT in Proton Irradiation of Grade I Meningioma Open
Grade I meningioma is the most common intracranial tumor in adults. The standard imaging for its radiation treatment planning is MRI, and [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated PET/CT can further i…
View article: A Review of Particle Therapy for Skull Base Tumors: Modern Considerations and Future Directions
A Review of Particle Therapy for Skull Base Tumors: Modern Considerations and Future Directions Open
Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy r…
View article: Clinical outcomes of head and neck adenoid cystic carcinoma patients treated with pencil beam-scanning proton therapy
Clinical outcomes of head and neck adenoid cystic carcinoma patients treated with pencil beam-scanning proton therapy Open
PBS PT is an effective and safe treatment for patients with head & neck ACC in both definitive and adjuvant setting. Distant metastases are the main pattern of failure. Age, tumor stage and clinical stage had a significant negative impact …
View article: OS6.5 The prognostic usability of Ga68-DOTA-TATE PET-CT in irradiated meningioma
OS6.5 The prognostic usability of Ga68-DOTA-TATE PET-CT in irradiated meningioma Open
View article: Prognostic value and clinical correlations of 18-fluorodeoxyglucose metabolism quantifiers in gastric cancer
Prognostic value and clinical correlations of 18-fluorodeoxyglucose metabolism quantifiers in gastric cancer Open
PET-CT in GC may represent a valuable diagnostic and prognostic tool that requires further evaluation in highly standardised environments such as randomised clinical trials.
View article: The prognostic significance of indoleamine-2,3-dioxygenase and the receptors for transforming growth factor β and interferon γ in metastatic lymph nodes in malignant melanoma
The prognostic significance of indoleamine-2,3-dioxygenase and the receptors for transforming growth factor β and interferon γ in metastatic lymph nodes in malignant melanoma Open
We analyzed the prognostic significance of indoleamine-2,3-dioxygenase (IDO) and type 1 receptors for transforming growth factor beta (TGF-βR1) and interferon gamma (IFN-γR1) in resected nodal metastases of 48 malignant melanoma patients. …