Mack Miller
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View article: First‐in‐human positron emission tomography study of intranasal insulin in aging and MCI
First‐in‐human positron emission tomography study of intranasal insulin in aging and MCI Open
Introduction Intranasal insulin (INI) is being explored to treat Alzheimer's disease and other conditions. The method of intranasal delivery has been shown to affect outcomes, requiring validation prior to clinical investigation. We conduc…
View article: Radiation-induced brain injury in non-human primates: A dual tracer PET study with [11C]MPC-6827 and [11C]PiB
Radiation-induced brain injury in non-human primates: A dual tracer PET study with [11C]MPC-6827 and [11C]PiB Open
Radiation-induced brain injury (RIBI) and Alzheimer's disease (AD) share key pathological features, including β-amyloid (Aβ) plaque formation and microtubule (MT) destabilization, both contributing to neurodegeneration. This pilot study as…
View article: PET imaging utility of a novel Aβ‐tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys
PET imaging utility of a novel Aβ‐tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys Open
Background Older vervet monkeys are an excellent model for studying age‐associated Aß deposition; however, they have high proportions of low‐affinity Aß sites compared to human brains. Commonly used Aß PET radiotracers are most useful in d…
View article: First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease
First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease Open
Background The G protein‐coupled receptor GPR39 is heavily associated with the pathogenesis of neurologic disorders, including Alzheimer’s disease (AD) and related dementia (ADRD). Its dysregulation of zinc 2+ (Zn 2+ ) processes triggers m…
View article: First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease
First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease Open
Background The G protein‐coupled receptor GPR39 is heavily associated with the pathogenesis of neurologic disorders, including Alzheimer’s disease (AD) and related dementia (ADRD). Its dysregulation of zinc 2+ (Zn2+) processes triggers met…
View article: Exploring Microtubule Dynamics in Alzheimer's Disease: Longitudinal Assessment Using [<sup>11</sup>C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models
Exploring Microtubule Dynamics in Alzheimer's Disease: Longitudinal Assessment Using [<sup>11</sup>C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models Open
Background Brains affected by Alzheimer's disease (AD) exhibit senile plaques containing amyloid beta (Aβ) peptides and neurofibrillary tangles, formed when tau becomes hyperphosphorylated and disengages from microtubules (MTs). Early inst…
View article: Exploring Microtubule Dynamics in Alzheimer’s Disease: Longitudinal Assessment Using [11C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models
Exploring Microtubule Dynamics in Alzheimer’s Disease: Longitudinal Assessment Using [11C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models Open
Background Brains affected by Alzheimer’s disease (AD) exhibit senile plaques containing amyloid beta (Aß) peptides and neurofibrillary tangles, formed when tau becomes hyperphosphorylated and disengages from microtubules (MTs). Early inst…
View article: First Comprehensive Intranasal PET imaging of Insulin using the Aptar device in Nonhuman Primates
First Comprehensive Intranasal PET imaging of Insulin using the Aptar device in Nonhuman Primates Open
Background Insulin resistance (IR) is associated with abnormal tau‐phosphorylation and IR markers in AD brain co‐localize with neurofibrillary tangles. One strategy to overcome brain IR is to increase brain insulin is via intranasal insuli…
View article: First Comprehensive Intranasal PET imaging of Insulin using the Aptar device in Nonhuman Primates
First Comprehensive Intranasal PET imaging of Insulin using the Aptar device in Nonhuman Primates Open
Background Insulin resistance (IR) is associated with abnormal tau‐phosphorylation and IR markers in AD brain co‐localize with neurofibrillary tangles. One strategy to overcome brain IR is to increase brain insulin is via intranasal insuli…
View article: PET imaging utility of a novel Aβ‐tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys
PET imaging utility of a novel Aβ‐tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys Open
Background Older vervet monkeys are an excellent model for studying age‐associated Aβ deposition; however, they have high proportions of low‐affinity Aβ sites compared to human brains. Commonly used Aβ PET radiotracers are most useful in d…
View article: PET Imaging of Microtubules in Cognitively Impaired and Normal Older Adults
PET Imaging of Microtubules in Cognitively Impaired and Normal Older Adults Open
Background Although associated with early changes in Aβ and tau formations, microtubule (MT) destabilization has not yet been systematically evaluated as an early biomarker of neurodegeneration and a tool to quantify it in real‐time could …
View article: Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [<sup>11</sup>C]MPC‐6827 PET imaging in rodent models of Alzheimer's‐related pathology
Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [<sup>11</sup>C]MPC‐6827 PET imaging in rodent models of Alzheimer's‐related pathology Open
INTRODUCTION Microtubule (MT) stability is crucial for proper neuronal function. Understanding MT dysregulation is critical for connecting amyloid beta (Aβ) and tau‐based degenerative events and early changes in presymptomatic Alzheimer's …
View article: Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease
Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease Open
Background While microtubule (MT)‐destabilization and synaptic loss hallmark AD pathological events, no study has systematically quantified their in vivo levels in the same brain. Any therapeutic intervention relying on MT destabilization …
View article: Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease
Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease Open
Background While microtubule (MT)‐destabilization and synaptic loss hallmark AD pathological events, no study has systematically quantified their in vivo levels in the same brain. Any therapeutic intervention relying on MT destabilization …
View article: Preliminary PET Imaging of Microtubule-Based PET Radioligand [<sup>11</sup>C]MPC-6827 in a Nonhuman Primate Model of Alzheimer’s Disease
Preliminary PET Imaging of Microtubule-Based PET Radioligand [<sup>11</sup>C]MPC-6827 in a Nonhuman Primate Model of Alzheimer’s Disease Open
The microtubule (MT) instability observed in Alzheimer's disease (AD) is commonly attributed to hyperphosphorylation of the MT-associated protein, tau. In vivo PET imaging offers an opportunity to gain critical information about MT changes…
View article: First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations
First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations Open
G-protein-coupled receptor 119 (GPR119) has emerged as a promising target for treating type 2 diabetes mellitus. Activating GPR119 improves glucose homeostasis, while suppressing appetite and weight gain. Measuring GPR119 levels in vivo co…
View article: Preliminary biological evaluations of first brain‐penetrant GPR119‐based radiotracer in rodents and non‐human primates
Preliminary biological evaluations of first brain‐penetrant GPR119‐based radiotracer in rodents and non‐human primates Open
Background G‐protein‐coupled receptors (GPCRs) plays a key role in regulating glucose metabolism. While GPR119 (an important GPCR) agonists have shown potential for improving neurologic and cognitive function in patients with AD and type2 …
View article: Binding Parameters of [11C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents
Binding Parameters of [11C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents Open
Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer’s disease (AD), Parkinson’s disease and other neurological dis…
View article: Prolonged exposure to cocaine self-administration results in a continued progression of alterations in functional activity in a nonhuman primate model
Prolonged exposure to cocaine self-administration results in a continued progression of alterations in functional activity in a nonhuman primate model Open
These findings demonstrate a clear progression of the impact of cocaine on functional activity with increasing durations of drug experience and have important implications for the development of potential strategies for the treatment of co…
View article: Positron Emission Tomography-Computed Tomography Imaging of Selective Lobar Delivery of Stem Cells in <i>Ex Vivo</i> Lung Model of Mechanical Ventilation
Positron Emission Tomography-Computed Tomography Imaging of Selective Lobar Delivery of Stem Cells in <i>Ex Vivo</i> Lung Model of Mechanical Ventilation Open
Introduction: The delivery of cell therapies may be an important frontier to treat different respiratory diseases in the near future. However, the cell size, delivery conditions, cell viability, and effect in the pulmonary function are cri…
View article: [18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates
[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates Open
Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging is recognized as the standard tool for cancer imaging, there are no clinically-…
View article: Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model
Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model Open
Background Microtubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD) pathogenesis as evidenced by persistent negative regulation (phosphorylation) of the neuronal …
View article: Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse
Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse Open
Purpose Microtubules (MTs) are structural units made of α and β tubulin subunits in the cytoskeleton responsible for axonal transport, information processing, and signaling mechanisms—critical for healthy brain function. Chronic cocaine ex…