Mackenzie Bloom
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View article: ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice
ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice Open
ETS variant 6 (ETV6) encodes a transcriptional repressor expressed in hematopoietic stem and progenitor cells (HSPCs), where it is required for adult hematopoiesis. Heterozygous pathogenic germline ETV6 variants are associated with thrombo…
View article: Cellular and transcriptional impacts of Janus kinase and/or IFN-gamma inhibition in a mouse model of primary hemophagocytic lymphohistiocytosis
Cellular and transcriptional impacts of Janus kinase and/or IFN-gamma inhibition in a mouse model of primary hemophagocytic lymphohistiocytosis Open
Background Primary hemophagocytic lymphohistiocytosis (pHLH) is an inherited inflammatory syndrome driven by the exuberant activation of interferon-gamma (IFNg)-producing CD8 T cells. Towards this end, ruxolitinib treatment or IFNg neutral…
View article: Molecular basis of <i>ETV6</i>-mediated predisposition to childhood acute lymphoblastic leukemia
Molecular basis of <i>ETV6</i>-mediated predisposition to childhood acute lymphoblastic leukemia Open
There is growing evidence supporting an inherited basis for susceptibility to acute lymphoblastic leukemia (ALL) in children. In particular, we and others reported recurrent germline ETV6 variants linked to ALL risk, which collectively rep…
View article: Recent advances in genetic predisposition to pediatric acute lymphoblastic leukemia
Recent advances in genetic predisposition to pediatric acute lymphoblastic leukemia Open
Introduction: Historically, the majority of childhood cancers, including acute lymphoblastic leukemia (ALL), were not thought to have a hereditary basis. However, recent germline genomic studies have revealed that at least 5 - 10% of child…