Mackenzie J. Parker
YOU?
Author Swipe
View article: Exercise Capacity Following Pulmonary Embolism in Children and Adolescents
Exercise Capacity Following Pulmonary Embolism in Children and Adolescents Open
Background: Self-reported physical activity after pediatric pulmonary embolism (PE) is reduced after diagnosis. However, objectively measured exercise capacity and mechanisms of exercise pathophysiology after PE are unknown. Research Quest…
View article: Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay Open
Werner syndrome protein (WRN) is a multifunctional enzyme with helicase, ATPase, and exonuclease activities that are necessary for numerous DNA-related transactions in the human cell. Recent studies identified WRN as a synthetic lethal tar…
View article: Pathways of thymidine hypermodification
Pathways of thymidine hypermodification Open
The DNAs of bacterial viruses are known to contain diverse, chemically complex modifications to thymidine that protect them from the endonuclease-based defenses of their cellular hosts, but whose biosynthetic origins are enigmatic. Up to h…
View article: Phage-encoded ten-eleven translocation dioxygenase (TET) is active in C5-cytosine hypermodification in DNA
Phage-encoded ten-eleven translocation dioxygenase (TET) is active in C5-cytosine hypermodification in DNA Open
Significance Chemical tailoring of canonical bases expands the functionality of DNA in the same manner that posttranscriptional and -translational modifications enhance functional diversity in RNA and proteins. We describe the activities o…
View article: Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice
Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice Open
Many patients of choroidal neovascularization (CNV) are unresponsive to the current anti-VEGF treatment. The mechanisms for anti-VEGF resistance are poorly understood. We explore the unique property of the apolipoprotein A-I (apoA-I) bindi…
View article: A novel form of allosteric regulation in <i>Bacillus subtilis</i> ribonucleotide reductase revealed by SAXS and cryo-electron microscopy
A novel form of allosteric regulation in <i>Bacillus subtilis</i> ribonucleotide reductase revealed by SAXS and cryo-electron microscopy Open
DNA replication and repair are required for all modern life on Earth.De novo synthesis of the building blocks of DNA is carried out by the essential enzyme ribonucleotide reductase (RNR), which reduces the precursors of RNA (ribonucleotide…
View article: An endogenous dAMP ligand in<i>Bacillus subtilis</i>class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP
An endogenous dAMP ligand in<i>Bacillus subtilis</i>class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP Open
Significance Negative feedback regulation of ribonucleotide reductase (RNR) activity by dATP is important for maintaining balanced intracellular 2ʹ-deoxynucleoside triphosphate (dNTP) pools essential for the high fidelity of DNA replicatio…
View article: An endogenous dAMP ligand in
An endogenous dAMP ligand in Open
© 2018 National Academy of Sciences. All rights reserved. The high fidelity of DNA replication and repair is attributable, in part, to the allosteric regulation of ribonucleotide reductases (RNRs) that maintains proper deoxynucleotide pool…
View article: Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer
Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer Open
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleoside diphosphate substrates (S) to deoxynucleotides with allosteric effectors (e) controlling their relative ratios and amounts, crucial for fidelity of DNA replication and …
View article: Discovery and investigation of the novel overall activity allosteric regulation of the Bacillus subtilis class Ib ribonucleotide reductase
Discovery and investigation of the novel overall activity allosteric regulation of the Bacillus subtilis class Ib ribonucleotide reductase Open
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2017.