Mackenzie Williams
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Ten-Year Trend in the Potentially Inappropriate Prescribing of Renally-Dependent Medicines in Australian General Practice Patients with Dementia Open
Background: There is limited published evidence on the prevalence of potentially inappropriate prescribing of medicines in relation to kidney function in older Australians, particularly those with dementia. Objectives: To examine the preva…
Olfactory Dysfunction in a Novel Model of Prodromal Parkinson’s Disease in Adult Zebrafish Open
Olfactory dysfunction is a clinical marker of prodromal Parkinson’s disease (PD), yet the underlying mechanisms remain unclear. To explore this relationship, we developed a zebrafish model that recapitulates the olfactory impairment observ…
Factors Influencing Community Pharmacists’ Participation in Antimicrobial Stewardship: A Qualitative Inquiry Open
Very few studies, all employing surveys, have investigated the perceptions of community pharmacists regarding antimicrobial stewardship (AMS). A qualitative inquiry exploring factors affecting community pharmacists’ participation in AMS ma…
Olfactory dysfunction in a novel model of prodromal Parkinson’s disease in adult zebrafish Open
Olfactory dysfunction is an early clinical marker of prodromal Parkinson’s disease (PD), yet the underlying mechanisms remain unclear. To explore this relationship, we developed a zebrafish model that recapitulates prodromal PD-associated …
Factors Influencing Community Pharmacists’ Participation in Antimicrobial Stewardship: A Qualitative Inquiry Open
Very few studies, all employing surveys, have investigated the perceptions of community pharmacists regarding antimicrobial stewardship (AMS). A qualitative inquiry exploring factors affecting community pharmacists’ participation in AMS ma…
Remedies and the Baumgartner Joint Endeavour Principle: Aspects of the Minimum Equity Rule Open
The doctrine in Baumgartner v Baumgartner – the joint endeavour principle – is now a firmly entrenched feature of Australian equity jurisprudence. However, substantial uncertainties remain as to its remedial operation. It is unclear when t…
View article: The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol
The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol Open
Determining the genetic contributions to Parkinson’s disease (PD) across diverse ancestries is a high priority as this work can guide therapeutic development in a global setting. The genetics of PD spans the etiological risk spectrum, from…
Prevalence and Risk Factors of Inappropriate Drug Dosing among Older Adults with Dementia or Cognitive Impairment and Renal Impairment: A Systematic Review Open
Background: Potentially inappropriate medication prescribing is prevalent and well studied in older adults. However, limited data are available on inappropriate drug dosing in those with dementia or cognitive impairment and renal impairmen…
Maternal Antibiotic Exposure and the Risk of Developing Antenatal Depressive Symptoms Open
Background: Antenatal depression is common and has significant consequences. The literature suggests that antibiotic exposure may be associated with depression. Many individuals are exposed to antibiotics during pregnancy. Further investig…
Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study Protocol Open
Limited epidemiological evidence suggests a link between antibiotic use and developing depression. This study seeks to investigate this association in depth, using a cohort of pregnant individuals. The primary aim is to explore any associa…
Maternal antibiotic exposure and the risk of developing antenatal or postpartum depression: The Maternal Experience Study protocol Open
Background Limited epidemiological evidence suggests a link between antibiotic use and the development of depression. This study seeks to investigate this association in-depth, using a cohort of pregnant individuals. The primary aim is to …
Effect of an ongoing pharmacist service to reduce medicine-induced deterioration and adverse reactions in aged-care facilities (nursing homes): a multicentre, randomised controlled trial (the ReMInDAR trial) Open
Objective To assess the effectiveness of a pharmacist-led intervention using validated tools to reduce medicine-induced deterioration and adverse reactions. Design and setting Multicenter, open-label parallel randomised controlled trial in…
Reducing medicine-induced deterioration and adverse reactions (ReMInDAR) trial: study protocol for a randomised controlled trial in residential aged-care facilities assessing frailty as the primary outcome Open
Introduction Many medicines have adverse effects which are difficult to detect and frequently go unrecognised. Pharmacist monitoring of changes in signs and symptoms of these adverse effects, which we describe as medicine-induced deteriora…
Validation and implementation of a national survey to assess antimicrobial stewardship awareness, practices and perceptions amongst community pharmacists in Australia Open
Future studies utilising the knowledge gained from this study may provide a framework for AMS in community pharmacy settings.
A retrospective review of pain management in Tasmanian residential aged care facilities Open
Background The management of pain by GPs for residents of aged care facilities (ACFs) is very common. Aim To measure the prevalence and assess the management of pain in ACF residents, particularly those with dementia. Design & setting A re…
Perceptions and current practices of community pharmacists regarding antimicrobial stewardship in Tasmania Open
Background Despite increasing interest in antimicrobial stewardship (AMS), little is known about the related practices and perceptions of community pharmacists. Objective To develop and validate a questionnaire to measure the current pract…
Nurses' Knowledge of Pain Assessments and Reassessments Impacts Hospitalized Patients' Reporting of Pain Open
Ineffective pain management can prolong a patient's length of stay and increase cost of care. Inadequate pain control decreases the patient's quality of life and contributes to poor health outcomes. A recent record audit showed that docume…