Madalena C. Pinto
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View article: Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators
Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators Open
Cystic fibrosis (CF) is a life-shortening disease affecting >160,000 individuals worldwide predominantly with respiratory symptoms. About 80% of individuals with CF have the p.Phe508del variant that causes the CF transmembrane conductance …
View article: Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids
Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids Open
Individuals with cystic fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which impairs airway epithelial ion and fluid secretion. New CFTR …
View article: Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids
Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids Open
Individuals with Cystic Fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the Cystic Fibrosis Transmembrane conductance Regulator ( CFTR ) gene, which impairs airway epithelial ion and fluid secretion. New CFT…
View article: "Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis", CFTR interactomes
"Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis", CFTR interactomes Open
A tidy selection of published CFTR interactomes (or CFTR-related omics datasets) Collects data from the original online sources, converts gene/protein identifiers into a standard tidy format and updates the identifiers. The Unipro…
View article: "Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis", CFTR interactomes
"Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis", CFTR interactomes Open
A tidy selection of published CFTR interactomes (or CFTR-related omics datasets) Collects data from the original online sources, converts gene/protein identifiers into a standard tidy format and updates the identifiers. The Unipro…
View article: Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis
Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis Open
Cystic Fibrosis (CF) is a life-shortening disease affecting >90,000 individuals worldwide predominantly with respiratory symptoms. About 80% of individuals with CF have the F508del mutation that causes the CF transmembrane conductance regu…
View article: Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis
Global Functional Genomics Reveals GRK5 as a Therapeutic Target for Cystic Fibrosis Open
Cystic Fibrosis (CF) is a life-shortening disease affecting >90,000 individuals worldwide predominantly with respiratory symptoms. About 80% of individuals with CF have the F508del mutation that causes the CF transmembrane conductance regu…
View article: Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition
Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition Open
Mutations in the CFTR anion channel cause cystic fibrosis (CF) and have also been related to higher cancer incidence. Previously we proposed that this is linked to an emerging role of functional CFTR in protecting against epithelial–mesenc…
View article: CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system
CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system Open
View article: Synergy in Cystic Fibrosis Therapies: Targeting SLC26A9
Synergy in Cystic Fibrosis Therapies: Targeting SLC26A9 Open
SLC26A9, a constitutively active Cl− transporter, has gained interest over the past years as a relevant disease modifier in several respiratory disorders including Cystic Fibrosis (CF), asthma, and non-CF bronchiectasis. SLC26A9 contribute…
View article: Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis
Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis Open
Cystic fibrosis (CF) is a life-shortening monogenic disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, an anion channel that transports chloride and bicarbonate across epithelia. Des…
View article: Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation
Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation Open
Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher ex…
View article: Seasonal timing of reproductive migrations in adfluvial bull trout: an assessment of sex, spawning experience, population density, and environmental factors
Seasonal timing of reproductive migrations in adfluvial bull trout: an assessment of sex, spawning experience, population density, and environmental factors Open
Using individual tags combined with a fish fence operated at the mouth of Smith-Dorrien Creek, the primary spawning habitat for Lower Kananaskis Lake bull trout (Salvelinus confluentus), we approximated a complete census of the spawning po…