Ashok Kumar Singh
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View article: One-year outcomes of Bent ab-interno needle goniectomy with phacoemulsification in primary glaucoma
One-year outcomes of Bent ab-interno needle goniectomy with phacoemulsification in primary glaucoma Open
Purpose: To study 1-year outcomes of bent ab-interno needle goniectomy (BANG) with phacoemulsification in patients across the glaucoma spectrum. Methods: This Prospective, noncomparative interventional study enrolled primary glaucoma patie…
View article: Mining of resistance source for root-knot nematode (Meloidogyne incognita) in bitter gourd
Mining of resistance source for root-knot nematode (Meloidogyne incognita) in bitter gourd Open
Bitter gourd (Momordica charantia L.) is nutritionally and medicinally rich cucurbit crop and widely cultivated during summer and kharif season in India but suffer a lot with several biotic and abiotic stresses. Among biotic stresses, root…
View article: Cu(II) and Fe(III) Catalyzed Synthesis of Novel Thiophene Hybridized Thiadiazolyl Schiff Bases (TTS) as COX-2 Selective Inhibitor
Cu(II) and Fe(III) Catalyzed Synthesis of Novel Thiophene Hybridized Thiadiazolyl Schiff Bases (TTS) as COX-2 Selective Inhibitor Open
A novel series of thiophene hybridized thiadiazolyl Schiff bases (TTS) were designed and synthesized using copper nitrate (CuII) catalyzed synthesis of Schiff bases and their subsequent ferric chloride (FeIII) catalyzed cyclization into th…
View article: Fluticasone Furoate/Vilanterol Use Trends and Characteristics in Patients With Obstructive Airway Disease: A Real-World Study of 10,374 Patients From India
Fluticasone Furoate/Vilanterol Use Trends and Characteristics in Patients With Obstructive Airway Disease: A Real-World Study of 10,374 Patients From India Open
Introduction Obstructive Airway Diseases (OADs) are the leading cause of death among chronic respiratory diseases worldwide, and novel therapies are direly needed. Fluticasone furoate/vilanterol (FF/Vi) (100/25 µg) is the first once-daily …
View article: Cytomorphology of lymphadenopathy on fine needle aspiration cytology
Cytomorphology of lymphadenopathy on fine needle aspiration cytology Open
Introduction: FNAC is widely accepted the most accurate sensitive, specific, cost-effective minimally invasive OPD technique to establish the basic diagnostic information not only to relieve the anxiety of the patients but also to provide …
View article: Issue Information
Issue Information Open
Role of CD68 immunohistochemistry in categorizing benign nonmesothelial cell population and refining "atypical" category in serous fluid cytology Amanda Ama Coleman-Eghan, Pamela MichelowThe effect of antiretroviral therapy on fine-needle …
View article: Author Correction: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals
Author Correction: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: CLINICAL CORRELATION OF PURVAROOPA AVASTHA OF PRAMEHA WITH SROTADUSTHI: A REVIEW
CLINICAL CORRELATION OF PURVAROOPA AVASTHA OF PRAMEHA WITH SROTADUSTHI: A REVIEW Open
Srotas are the channels of the body which are designed for inner transport system of our body.According to Ayurveda all diseases are due to Srotadusthi as without existence of 'Kha-vaigunya' diseases cannot be manifested.Disease like Prame…
View article: Anti-spasmolytic and Anti-diarrheal Activities of Newbouldia laevis, Cola nitida and Acanthus montanus Extracts on Gastrointestinal Muscles
Anti-spasmolytic and Anti-diarrheal Activities of Newbouldia laevis, Cola nitida and Acanthus montanus Extracts on Gastrointestinal Muscles Open
Background and Objective: In developing countries, diarrhea is the leading cause of death in children.Several medicinal plants have been implicated in treatment of diarrhea.The present study was carried out to evaluate the anti-spasmolytic…
View article: Nutritional security through utilization of uncommon green leafy vegetables for product development
Nutritional security through utilization of uncommon green leafy vegetables for product development Open
The present study was conducted to collect information regarding physical, nutritional and product development potential of uncommon green leafy vegetables in Barabanki and Sultanpur district of eastern U.P so as to ensure nutritional secu…
View article: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals
Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals Open
Inspired by the well-documented tumor protecting ability of paullones, recently, we synthesized novel paullone-like scaffolds, indole-fused benzo-oxazepines (IFBOs), and screened them against hepatocellular carcinoma (HCC) specific Hep-G2 …
View article: Selective Colorimetric Sensors for Cyanide and Acetate Ion in Partially Aqueous Medium
Selective Colorimetric Sensors for Cyanide and Acetate Ion in Partially Aqueous Medium Open
4-(thiazol-2-yldiazenyl)phenol (L1) and 2-((4-hydroxyphenyl) diazenyl)-5-nitrophenol (L2) based on azo phenol were synthesised and used as selective colorimetric sensor for CN- and AcO− ion in DMSO/H2O-HEPES (v/v; 1:1, pH–7.3 &…
View article: Poly(lactic-<em>co</em>-glycolic acid)-loaded nanoparticles of betulinic acid for improved treatment of hepatic cancer: characterization, in vitro and in vivo evaluations
Poly(lactic-<em>co</em>-glycolic acid)-loaded nanoparticles of betulinic acid for improved treatment of hepatic cancer: characterization, in vitro and in vivo evaluations Open
The prepared BNP showed a better therapeutic response against HCC and could be attributed as future candidate molecule for HCC treatment.
View article: DETERMINATION OF 5H-BENZO[2,3][1,4]OXAZEPINO[5,6-B]INDOLES IN RAT PLASMA BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC-ULTRAVIOLET METHOD: APPLICATION TO PHARMACOKINETIC STUDIES
DETERMINATION OF 5H-BENZO[2,3][1,4]OXAZEPINO[5,6-B]INDOLES IN RAT PLASMA BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC-ULTRAVIOLET METHOD: APPLICATION TO PHARMACOKINETIC STUDIES Open
Objective: Recently, we reported newly synthesized 5H-benzo[2,3][1,4]oxazepino[5,6-b]indole) derivatives and proved their cytotoxicity against hepatocellular carcinoma specific Hep-G2 cell lines. We attempted herein to describe a reversed-…
View article: A METHOD FOR DETERMINING 1,4-BENZOTHIAZINE DERIVATIVES IN RAT PLASMA BY HPLC AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
A METHOD FOR DETERMINING 1,4-BENZOTHIAZINE DERIVATIVES IN RAT PLASMA BY HPLC AND ITS APPLICATION TO A PHARMACOKINETIC STUDY Open
Objective: The objective of the study was to develop, optimize and validate of a new reverse-phase high-performance liquid chromatography (RP-HPLC) method for the determining 1,4-benzothiazine derivatives (AR13 and AR15) in a biological sa…
View article: A comparative study of anticonvulsant effect of phenytoin and lamotrigine in albino mice
A comparative study of anticonvulsant effect of phenytoin and lamotrigine in albino mice Open
Background: The anticonvulsant activity of lamotrigine has been extensively studied and its role is established. Lamotrigine have shown recently to be useful in various epileptic seizures. Since antiepileptic drugs are used for longer dura…
View article: 5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction
5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction Open
5H-benzo[h]thiazolo[2,3-b]quinazoline scaffold is known to have an antitumor effect on certain types of malignancies; however, its effect on hepatocellular carcinoma (HCC) remains unclear. Previously, we reported p-toluenesulfonic acid-pro…
View article: 6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Attenuates Heptatocellular Carcinoma in Rats with NMR-Based Metabolic Perturbations
6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Attenuates Heptatocellular Carcinoma in Rats with NMR-Based Metabolic Perturbations Open
M1 manifested notable antiproliferative profile, and warrants further investigation for future anticancer therapy.
View article: <em>p</em>-TSA-promoted syntheses of 5H-benzo[h]thiazolo[2,3-b]quinazoline and indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma
<em>p</em>-TSA-promoted syntheses of 5H-benzo[h]thiazolo[2,3-b]quinazoline and indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma Open
In our efforts to address the rising incidence of hepatocellular carcinoma (HCC), we have made a commitment to the synthesis of novel molecules to combat Hep-G2 cells. A facile and highly efficient one-pot, multicomponent reaction has been…
View article: Ameliorative effects of pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma
Ameliorative effects of pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma Open
Pyrazinoic acid (PA) is structurally similar to nicotinic acid which acts on G-protein-coupled receptor (GPR109A). GPR109A expresses in colonic and intestinal epithelial sites, and involves in DNA methylation and cellular apoptosis. Theref…
View article: Indole-Fused Benzooxazepines: a New Structural Class of Anticancer Agents
Indole-Fused Benzooxazepines: a New Structural Class of Anticancer Agents Open
The most active compounds - 6a, 10a, 13a, 14a and 15a - exemplify notable anticancer profile with GI50 <10 μg/ml. Preliminary structure-activity relationship among the tested compounds can produce an assumption that the electronegative gro…
View article: Protective Effect of Naringin against Pylorus Ligation-induced Esophagitis in Male Wistar Rats
Protective Effect of Naringin against Pylorus Ligation-induced Esophagitis in Male Wistar Rats Open
The present study was undertaken to evaluate the effect of naringin, a naturally occurring flavonoid, on experimental esophagitis in Wistar rats. Animals divided into six groups and received carboxymethyl cellulose (0.25%, 3 ml/kg, sham co…
View article: CCDC 1445563: Experimental Crystal Structure Determination
CCDC 1445563: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Design and synthesis of 1,4-benzothiazine derivatives with promising effects against colorectal cancer cells
Design and synthesis of 1,4-benzothiazine derivatives with promising effects against colorectal cancer cells Open
In this study, we designed and synthesized a series of 1,4-benzothiazine and evaluated them for anticancer activity toward HT-29 human colon cancer cells using SRB assay. Before the synthesis, docking studies were performed using various m…
View article: OXIDATIVE STRESS-BASED HEPATOTOXICITY OF DULOXETINE IN WISTAR RATS
OXIDATIVE STRESS-BASED HEPATOTOXICITY OF DULOXETINE IN WISTAR RATS Open
Objective: Duloxetine, a selective serotonin and noradrenaline reuptake inhibitor used in major depressive disorders, urinary incontinence and diabetic peripheral neuropathic pain. It is reported to be associated with several types of live…
View article: An updated review on the phytochemistry, pharmacology, and clinical trials of Salacia oblonga
An updated review on the phytochemistry, pharmacology, and clinical trials of Salacia oblonga Open
Salacia oblonga (S. oblonga), a perennial herb, has been used for thousands of years in ayurvedic medicine and is closely associated with prevention, treatment, and cure of various human ailments such as obesity and diabetes. A vast and wi…