Madavan Vasudevan
YOU?
Author Swipe
View article: T13F2.2 of C. elegans is Critical for Chromatin Organization, Autophagy, and Longevity
T13F2.2 of C. elegans is Critical for Chromatin Organization, Autophagy, and Longevity Open
Intricately modulated by a spectrum of proteins, Chromatin structure governs gene expression and cellular homeostasis. In Caenorhabditis elegans, critical components like the TATA-binding protein tbp-1 play pivotal roles in orchestrating c…
View article: A study of SARS-CoV-2 genomic profiles, evolutionary changes, and transmission dynamics in Southeastern India during three pandemic waves
A study of SARS-CoV-2 genomic profiles, evolutionary changes, and transmission dynamics in Southeastern India during three pandemic waves Open
SARS-CoV-2 bio-surveillance at all levels is crucial for understanding its genetic evolution and vaccine effectiveness.This study investigated the emergence and evolution of new SARS-CoV-2 variants in the city of Puducherry, India througho…
View article: Featured Cover
Featured Cover Open
The cover image is based on the article Epigenetic modulation rescues neurodevelopmental deficits in Syngap1+/−; mice by Akash Kumar Singh et al.,https://doi.org/10.1111/acel.14408 [Image: see text]
View article: Additional Cover
Additional Cover Open
The cover image is based on the article Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model by Tamunotonye Omoluabi et al., https://doi.org/10.1111/acel.14405 [Image: see text]
View article: Epigenetic modulation rescues neurodevelopmental deficits in <i>Syngap1<sup>+/−</sup></i> mice
Epigenetic modulation rescues neurodevelopmental deficits in <i>Syngap1<sup>+/−</sup></i> mice Open
SYNGAP1 is a Ras GTPase‐activating protein that plays a crucial role during brain development and in synaptic plasticity. Sporadic heterozygous mutations in SYNGAP1 affect social and emotional behaviour observed in intellectual disability …
View article: Global proteomics reveals pathways of mesenchymal stem cells altered by Mycobacterium tuberculosis
Global proteomics reveals pathways of mesenchymal stem cells altered by Mycobacterium tuberculosis Open
Mycobacterium tuberculosis (M. tb) has a remarkable ability to persist inside host cells. Several studies showed that M. tb infects and survives inside bone marrow mesenchymal stem cells (BM-MSCs) escaping the host immune system. Here, we …
View article: ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis
ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis Open
Triple-negative breast cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming especially fatty ac…
View article: Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy
Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy Open
Lamins form a proteinaceous meshwork as a major structural component of the nucleus. Lamins, along with their interactors, act as determinants for chromatin organization throughout the nucleus. The major dominant missense mutations respons…
View article: Urolithin A mitigates behavioral and synaptic deficits associated with epilepsy through VDAC-1 inhibition: A novel treatment approach
Urolithin A mitigates behavioral and synaptic deficits associated with epilepsy through VDAC-1 inhibition: A novel treatment approach Open
The persistence of drug-resistant epilepsy indicates the need for new therapeutic interventions against novel targets with reduced side effects. One such approach is modifying underlying pathophysiological mechanisms of synaptic plasticity…
View article: Global proteomics reveals pathways of mesenchymal stem cells altered by Mycobacterium tuberculosis.
Global proteomics reveals pathways of mesenchymal stem cells altered by Mycobacterium tuberculosis. Open
Mycobacterium tuberculosis (M. tb) has a remarkable ability to persist inside host cells. Several studies showed that M. tb infects and survives inside bone marrow mesenchymal stem cells (BM-MSCs) escaping the host immune system. Here, we …
View article: Evaluation of lamin A/C mechanotransduction under different surface topography in <scp>LMNA</scp> related muscular dystrophy
Evaluation of lamin A/C mechanotransduction under different surface topography in <span>LMNA</span> related muscular dystrophy Open
Most of the single point mutations of the LMNA gene are associated with distinct muscular dystrophies, marked by heterogenous phenotypes but primarily the loss and symmetric weakness of skeletal muscle tissue. The molecular mechanism and p…
View article: UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling
UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling Open
The intricate interplay between resident cells and the extracellular matrix (ECM) profoundly influences cancer progression. In triple-negative breast cancer (TNBC), ECM architecture evolves due to the enrichment of lysyl oxidase, fibronect…
View article: GENOMIC PROFILING OF SARS-COV-2 STRAINS CIRCULATING IN SOUTH EASTERN REGION OF INDIA DURING THREE WAVES OF PANDEMIC
GENOMIC PROFILING OF SARS-COV-2 STRAINS CIRCULATING IN SOUTH EASTERN REGION OF INDIA DURING THREE WAVES OF PANDEMIC Open
Continuous bio-surveillance of SARS-CoV-2 is an ongoing task at local, national and global levels since the pandemic onset for understanding genetic evolution and vaccine efficacy. Present study was designed to track the emergence of new v…
View article: Epigenetic Modulation to perturb the<i>SYNGAP1</i>Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits
Epigenetic Modulation to perturb the<i>SYNGAP1</i>Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits Open
Sporadic heterozygous mutations in SYNGAP1 affects social and emotional behaviour that are often observed in intellectual disability (ID) and autism spectrum disorder (ASD). Although neurophysiological deficits have been extensively studie…
View article: ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression
ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression Open
Triple-Negative Breast Cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming has emerged as a ma…
View article: Three‐amino acid loop extension homeodomain proteins regulate stress responses and encystation in <i>Entamoeba</i>
Three‐amino acid loop extension homeodomain proteins regulate stress responses and encystation in <i>Entamoeba</i> Open
It is interesting to identify factors involved in the regulation of the encystation of Entamoeba histolytica that differentiate trophozoites into cysts. Evolutionarily conserved three amino acid loop extension (TALE) homeodomain proteins a…
View article: miRNA-mRNA Network in PBMCs of PCOS Women Identifies Overactivated Stress-Activated Kinases
miRNA-mRNA Network in PBMCs of PCOS Women Identifies Overactivated Stress-Activated Kinases Open
Background/Aims: Earlier studies have revealed the miRNAs and mRNAs involved in Polycystic Ovarian Syndrome (PCOS), but little is known about their regulatory networks. Methods: To address this issue, we applied a comprehensive miRNA, mRNA…
View article: Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid‐beta 1–42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons
Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid‐beta 1–42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons Open
The master epigenetic regulator lysine acetyltransferase (KAT) p300/CBP plays a pivotal role in neuroplasticity and cognitive functions. Recent evidence has shown that in several neurodegenerative diseases, including Alzheimer's disease (A…
View article: Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy
Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy Open
In metazoan cells, lamins form a proteinaceous meshwork as a major structural component of the nucleus and also play a role in regulating essential cellular processes. Lamins, along with their interactors, act as determinants for chromatin…
View article: Chemosensitizing effect of neferine on cisplatin-resistant colorectal cancer: Identification of potential candidate genes and pathways through whole transcriptome profiling
Chemosensitizing effect of neferine on cisplatin-resistant colorectal cancer: Identification of potential candidate genes and pathways through whole transcriptome profiling Open
Background: Cisplatin drug resistance is a serious impediment for the therapeutic success against platinum-based chemotherapy in several cancers. Neferine, a bisbenzylisoquinoline alkaloid from Nelumbo nucifera is an effective anticancer a…
View article: Interconnection between molecular regulators in LMNA related muscular dystrophy
Interconnection between molecular regulators in LMNA related muscular dystrophy Open
Nuclear lamina is composed of different A-type and B-type lamin proteins and acts as major regulator of DNA replication, transcription, heterochromatin-euchromatin machinery. The majority of mutations in A type lamin are associated with so…
View article: Evaluation of lamin A/C mechanotransduction under different surface topography in LMNA related muscular dystrophy
Evaluation of lamin A/C mechanotransduction under different surface topography in LMNA related muscular dystrophy Open
Most of the single point mutations of the LMNA gene are associated with distinct muscular dystrophies, marked by heterogenous phenotypes but primarily the loss and symmetric weakness of skeletal muscle tissue. The molecular mechanism and p…
View article: Identification of miRNAs associated with dendritic cell dysfunction during acute and chronic hepatitis B virus infection
Identification of miRNAs associated with dendritic cell dysfunction during acute and chronic hepatitis B virus infection Open
The uptake or expression of hepatitis B virus (HBV) proteins by dendritic cells (DCs) is considered important for disease outcome. Differential expression of microRNA (miRNA) may have a role in viral persistence and hepatocellular injury. …
View article: The Signature Amino Acid Residue Serine 31 of HIV-1C Tat Potentiates an Activated Phenotype in Endothelial Cells
The Signature Amino Acid Residue Serine 31 of HIV-1C Tat Potentiates an Activated Phenotype in Endothelial Cells Open
The natural cysteine to serine variation at position 31 of Tat in HIV-1C disrupts the dicysteine motif attenuating the chemokine function of Tat. We ask if there exists a trade-off in terms of a gain of function for HIV-1C Tat due to this …
View article: Comparative transcriptome analysis of pigeonpea, Cajanus cajan (L.) and one of its wild relatives Cajanus platycarpus (Benth.) Maesen
Comparative transcriptome analysis of pigeonpea, Cajanus cajan (L.) and one of its wild relatives Cajanus platycarpus (Benth.) Maesen Open
Pigeonpea is a major source of dietary protein to the vegetarian population of the Indian sub-continent. Crop improvement to mitigate biotic and abiotic stresses for realization of its potential yield and bridging yield gap is the need of …
View article: Functional interplay between YY1 and CARM1 promotes oral carcinogenesis
Functional interplay between YY1 and CARM1 promotes oral carcinogenesis Open
Coactivator associated arginine methyltransferase 1 (CARM1) has been functionally implicated in maintenance of pluripotency, cellular differentiation and tumorigenesis; where it plays regulatory roles by virtue of its ability to coactivate…
View article: Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier
Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier Open
Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the collectin …
View article: Comparative genomic analysis of a naturally competent Elizabethkingia anophelis isolated from an eye infection
Comparative genomic analysis of a naturally competent Elizabethkingia anophelis isolated from an eye infection Open
Elizabethkingia anophelis has now emerged as an opportunistic human pathogen. However, its mechanisms of transmission remain unexplained. Comparative genomic (CG) analysis of E. anopheles endophthalmitis strain surprisingly found from an e…
View article: Publisher Correction: Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress
Publisher Correction: Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress Open
A correction to this article has been published and is linked from the HTML and PDF version of this paper. The error has been fixed in the paper.