Federico Pisanu
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View article: Speciation and structural transformation of a V<sup>V</sup>–malate complex in the absence and in the presence of a protein: from a dinuclear species to decavanadate
Speciation and structural transformation of a V<sup>V</sup>–malate complex in the absence and in the presence of a protein: from a dinuclear species to decavanadate Open
Cs 2 [VV2O 4 (malato) 2 ]·2H 2 O can undergo transformation into a variety of V-containing species which can interact with proteins through multiple binding modes and stabilization mechanisms.
View article: Non‐Covalent and Covalent Binding of New Mixed‐Valence Cage‐like Polyoxidovanadate Clusters to Lysozyme
Non‐Covalent and Covalent Binding of New Mixed‐Valence Cage‐like Polyoxidovanadate Clusters to Lysozyme Open
The high‐resolution X‐ray structures of the model protein lysozyme in the presence of the potential drug [V IV O(acetylacetonato) 2 ] from crystals grown in 1.1 M NaCl, 0.1 M sodium acetate at pH 4.0 reveal the binding to the protein of di…
View article: Non‐Covalent and Covalent Binding of New Mixed‐Valence Cage‐like Polyoxidovanadate Clusters to Lysozyme
Non‐Covalent and Covalent Binding of New Mixed‐Valence Cage‐like Polyoxidovanadate Clusters to Lysozyme Open
The high‐resolution X‐ray structures of the model protein lysozyme in the presence of the potential drug [V IV O(acetylacetonato) 2 ] from crystals grown in 1.1 M NaCl, 0.1 M sodium acetate at pH 4.0 reveal the binding to the protein of di…
View article: Experimental and Computational Studies on the Interaction of DNA with Hesperetin Schiff Base CuII Complexes
Experimental and Computational Studies on the Interaction of DNA with Hesperetin Schiff Base CuII Complexes Open
The interactions with calf thymus DNA (CT-DNA) of three Schiff bases formed by the condensation of hesperetin with benzohydrazide (HHSB or L1H3), isoniazid (HIN or L2H3), or thiosemicarbazide (HTSC or L3H3) and their CuII complexes (CuHHSB…
View article: Solution chemistry of oxidovanadium(IV) complexes with two bis-kojic acid derivatives
Solution chemistry of oxidovanadium(IV) complexes with two bis-kojic acid derivatives Open
Despite the recognized importance of vanadium compounds in biological systems, including insulin-mimetic properties of oxidovanadium(IV) complexes, namely those with two units of natural occurring mono-hydroxypyrone ligands, as kojic acid,…
View article: Implications of Protein Interaction in the Speciation of Potential V<sup>IV</sup>O–Pyridinone Drugs
Implications of Protein Interaction in the Speciation of Potential V<sup>IV</sup>O–Pyridinone Drugs Open
Vanadium complexes (VCs) are promising agents for the treatment, among others, of diabetes and cancer. The development of vanadium-based drugs is mainly limited by a scarce knowledge of the active species in the target organs, which is oft…
View article: CCDC 2004342: Experimental Crystal Structure Determination
CCDC 2004342: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2004343: Experimental Crystal Structure Determination
CCDC 2004343: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2004341: Experimental Crystal Structure Determination
CCDC 2004341: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A Series of Non-Oxido V<sup>IV</sup>Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity
A Series of Non-Oxido V<sup>IV</sup>Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity Open
A series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1-4)2] (1-4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1-4, are reported. All the synthesized non-oxido VIV compounds…
View article: Interaction of V<sup>IV</sup>O–8-hydroxyquinoline species with RNase A: the effect of metal ligands in the protein adduct stabilization
Interaction of V<sup>IV</sup>O–8-hydroxyquinoline species with RNase A: the effect of metal ligands in the protein adduct stabilization Open
The interaction of [V IV O(8-HQ) 2 ] (8-HQ – = 8-hydroxyquinolato) with RNase A occurs upon binding of Glu111 to [V IV O(8-HQ)(H 2 O)] + moiety and release of one 8-HQ – . It is influenced not only by the stability of V species but also by…
View article: Binding of V<sup>IV</sup>O<sup>2+</sup>, V<sup>IV</sup>OL, V<sup>IV</sup>OL<sub>2</sub> and V<sup>V</sup>O<sub>2</sub>L Moieties to Proteins: X‐ray/Theoretical Characterization and Biological Implications
Binding of V<sup>IV</sup>O<sup>2+</sup>, V<sup>IV</sup>OL, V<sup>IV</sup>OL<sub>2</sub> and V<sup>V</sup>O<sub>2</sub>L Moieties to Proteins: X‐ray/Theoretical Characterization and Biological Implications Open
Vanadium compounds have frequently been proposed as therapeutics, but their application has been hampered by the lack of information on the different V‐containing species that may form and how these interact with blood and cell proteins, a…