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View article: High content 3D imaging by dual-view oblique plane microscopy
High content 3D imaging by dual-view oblique plane microscopy Open
Oblique plane microscopy (OPM) is a form of light-sheet fluorescence microscopy (LSFM) employing a single microscope objective at the sample for both fluorescence excitation and detection. Dual-view OPM (dOPM) is an optically folded form o…
View article: Identifying tissue states by spatial protein patterns related to chemotherapy response in triple-negative breast cancer
Identifying tissue states by spatial protein patterns related to chemotherapy response in triple-negative breast cancer Open
Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited targeted therapies and variable responses to conventional chemotherapy, influenced by intratumoral heterogeneity and complex tumor microenvironment (TME) interac…
View article: Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast Cancer
SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast Cancer Open
A major challenge in treating Triple-Negative Breast Cancer (TNBC) lies in its molecular, morphological and clinical heterogeneity, which hampers accurate prediction of responses to neoadjuvant treatment. To address this, we introduce SMAR…
View article: Nanoneedles enable spatiotemporal lipidomics of living tissues
Nanoneedles enable spatiotemporal lipidomics of living tissues Open
Spatial biology provides high-content diagnostic information by mapping the molecular composition of tissues. However, traditional spatial biology approaches typically require non-living samples, limiting temporal analysis. Here, to addres…
View article: Exploring faculty retention at community colleges
Exploring faculty retention at community colleges Open
This quantitative cross-sectional survey study investigates the relationships between demographic characteristics, campus climate perceptions, and retention plans of faculty at community colleges in the North Atlantic Region of the United …
View article: Development of three-color FRET measurement of force-dependent sensing of RIAM-Vinculin interactions in focal adhesions
Development of three-color FRET measurement of force-dependent sensing of RIAM-Vinculin interactions in focal adhesions Open
Förster resonance energy transfer (FRET) is a powerful technique for probing molecular interactions and conformational changes in biological systems. Cascade-FRET, a multistep energy transfer system involving three fluorophores, enables sp…
View article: Label-Free Analysis of Red Blood Cell Storage Lesions Using Imaging Flow Cytometry
Label-Free Analysis of Red Blood Cell Storage Lesions Using Imaging Flow Cytometry Open
Deleterious changes, collectively termed as storage lesions, alter the characteristics of red blood cell (RBC) morphology during in vitro storage. Due to gradual loss of cellular membrane, RBCs lose their original biconcave disk shape and …
View article: Label-Free Analysis of Red Blood Cell Storage Lesions Using Imaging Flow Cytometry
Label-Free Analysis of Red Blood Cell Storage Lesions Using Imaging Flow Cytometry Open
Deleterious changes, collectively termed as storage lesions, alter the characteristics of red blood cell (RBC) morphology during in vitro storage. Due to gradual loss of cellular membrane, RBCs lose their original biconcave disk shape and …
View article: Defining and modeling dynamic spatial heterogeneity within tumor microenvironments
Defining and modeling dynamic spatial heterogeneity within tumor microenvironments Open
Many solid tumors exhibit significant genetic, cellular, and biophysical heterogeneity which dynamically evolves during disease progression and after treatment. This constant flux in cell composition, phenotype, spatial relationships, and …
View article: Cell adhesion and migration in disease: translational and therapeutic opportunities
Cell adhesion and migration in disease: translational and therapeutic opportunities Open
In September 2023 members of the cell adhesion and cell migration research community came together to share their latest research and consider how our work might be translated for clinical practice. Alongside invited speakers, selected spe…
View article: Data-modeling the interplay between single cell shape, single cell protein expression, and tissue state
Data-modeling the interplay between single cell shape, single cell protein expression, and tissue state Open
Changes in cell shape are fundamentally involved in signaling, intracellular organization, function, and intercellular interactions within tissues, in health and disease. Investigating the interplay between cell shape and protein expressio…
View article: Integrating Porous Silicon Nanoneedles within Medical Devices for Nucleic Acid Nanoinjection
Integrating Porous Silicon Nanoneedles within Medical Devices for Nucleic Acid Nanoinjection Open
Porous silicon nanoneedles can interface with cells and tissues with minimal perturbation for high-throughput intracellular delivery and biosensing. Typically, nanoneedle devices are rigid, flat, and opaque, which limits their use for topi…
View article: Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion
Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion Open
Asthma is deemed an inflammatory disease, yet the defining diagnostic feature is mechanical bronchoconstriction. We previously discovered a conserved process called cell extrusion that drives homeostatic epithelial cell death when cells be…
View article: Multimodal bioimaging across disciplines and scales: challenges, opportunities and breaking down barriers
Multimodal bioimaging across disciplines and scales: challenges, opportunities and breaking down barriers Open
Multimodal bioimaging is a broad term used to describe experimental workflows that employ two or more different imaging modalities. Such approaches have been in use across life science domains for several years but these remain relatively …
View article: Imaging actin organisation and dynamics in 3D
Imaging actin organisation and dynamics in 3D Open
The actin cytoskeleton plays a critical role in cell architecture and the control of fundamental processes including cell division, migration and survival. The dynamics and organisation of F-actin have been widely studied in a breadth of c…
View article: A Method for Assessing the Lake Trophic Status Using Hyperspectral Reflectance (400–900 nm) Measured Above Water
A Method for Assessing the Lake Trophic Status Using Hyperspectral Reflectance (400–900 nm) Measured Above Water Open
The effective monitoring of eutrophication in inland water bodies is crucial for environmental management and pollution prevention. This study conducts a comprehensive analysis of in situ hyperspectral reflectance data (400–900 nm) and the…
View article: Opto‐Lipidomics of Tissues
Opto‐Lipidomics of Tissues Open
Lipid metabolism and signaling play pivotal functions in biology and disease development. Despite this, currently available optical techniques are limited in their ability to directly visualize the lipidome in tissues. In this study, opto‐…
View article: Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion
Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion Open
Breast cancer is characterized by physical changes that occur in the tumor microenvironment throughout growth and metastasis of tumors. Extracellular matrix stiffness increases as tumors develop and spread, with stiffer environments though…
View article: The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma
The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma Open
Introduction: Asthma is the most common chronic inflammatory disease of the airways. The airway epithelium is a key driver of the disease, and numerous studies have established genome-wide differences in mRNA expression between health and …
View article: Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Reviewer #2 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Reviewer #2 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Reviewer #1 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Reviewer #1 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth Open
Correction to: Nature Communications https://doi.org/10.1038/s41467-020-16618-6, published online 04 June 2020 The original version of this Article contained errors in Supplementary Fig. 1d in which the H&E; stained sections of lung, heart…
View article: Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…