Madeleine Scott
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View article: Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: A prevention strategy against neurodegeneration
Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: A prevention strategy against neurodegeneration Open
View article: Author Correction: Systems vaccinology of the BNT162b2 mRNA vaccine in humans
Author Correction: Systems vaccinology of the BNT162b2 mRNA vaccine in humans Open
View article: Mobbing behavior of songbirds in response to calls of an ambush-predator, the Northern Pygmy-Owl
Mobbing behavior of songbirds in response to calls of an ambush-predator, the Northern Pygmy-Owl Open
Mobbing is a widespread but risky behavior where prey actually approach and may even attack their predators. Small songbirds gather in multi-species flocks to direct mobbing at birds of prey such as the Northern Pygmy-Owl ( Glaucidium gnom…
View article: Brain Transcriptomic, Metabolic and Mitohormesis Properties Associated with N-Propargylglycine Treatment: A Prevention Strategy Against Neurodegeneration
Brain Transcriptomic, Metabolic and Mitohormesis Properties Associated with N-Propargylglycine Treatment: A Prevention Strategy Against Neurodegeneration Open
View article: 1539. A Nine-Gene Blood-Based Signature Meets the World Health Organization Target Product Profiles for Diagnosis of Active Tuberculosis and Predicting Progression from Latent to Active Disease
1539. A Nine-Gene Blood-Based Signature Meets the World Health Organization Target Product Profiles for Diagnosis of Active Tuberculosis and Predicting Progression from Latent to Active Disease Open
Background As part of its End TB strategy, the WHO has identified the need for non-sputum-based diagnostics that meet target product profiles (TPP) of 90% sensitivity and 70% specificity for diagnosis of Active TB (ATB) and 75% sensitivity…
View article: Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine Open
View article: A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice
A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice Open
View article: Correction to: N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties
Correction to: N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties Open
View article: Computational drug repositioning of atorvastatin for ulcerative colitis
Computational drug repositioning of atorvastatin for ulcerative colitis Open
Objective Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatment and disease maintenance. We hypothesized that a multi-cohort analysis of independent cohorts representi…
View article: Systems vaccinology of the BNT162b2 mRNA vaccine in humans
Systems vaccinology of the BNT162b2 mRNA vaccine in humans Open
View article: N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties Open
View article: Molecular and Clinical Data Integration Identifies an Association Between Decreased Colectomy Rates and Atorvastatin Exposure in Ulcerative Colitis Patients: A Retrospective Cohort Study
Molecular and Clinical Data Integration Identifies an Association Between Decreased Colectomy Rates and Atorvastatin Exposure in Ulcerative Colitis Patients: A Retrospective Cohort Study Open
View article: A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker
A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker Open
An early biomarker would transform our ability to screen and treat patients with cancer. The large amount of multi-scale molecular data in public repositories from various cancers provide unprecedented opportunities to find such a biomarke…
View article: A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker
A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker Open
An early biomarker would transform our ability to screen and treat patients with cancer. The large amount of multi-scale molecular data in public repositories from various cancers provide unprecedented opportunities to find such a biomarke…
View article: Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans Open
Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a compr…
View article: T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers
T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers Open
View article: CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains Open
View article: Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study
Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study Open
View article: 119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response
119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response Open
Background The World Health Organization (WHO) has identified the need for a nonsputum-based triage test for tuberculosis (TB) that can be used to identify those who need further testing to identify active disease. We investigated whether …
View article: Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response Open
Across 3 independent prospective cohorts, the 3-gene TB score approaches the World Health Organization target product profile benchmarks for non-sputum-based triage test with high negative predictive value. This gene expression diagnostic …
View article: META-ANALYSIS OF CONTINUOUS PHENOTYPES IDENTIFIES A GENE SIGNATURE THAT CORRELATES WITH COPD DISEASE STATUS
META-ANALYSIS OF CONTINUOUS PHENOTYPES IDENTIFIES A GENE SIGNATURE THAT CORRELATES WITH COPD DISEASE STATUS Open
The utility of multi-cohort two-class meta-analysis to identify robust differentially expressed gene signatures has been well established. However, many biomedical applications, such as gene signatures of disease progression, require one-c…