Madeline A. Farringer
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View article: Cellular and molecular basis of <i>Pf</i>Coronin function in artemisinin resistance in <i>Plasmodium falciparum</i>
Cellular and molecular basis of <i>Pf</i>Coronin function in artemisinin resistance in <i>Plasmodium falciparum</i> Open
Summary Artemisinin-based therapies are central to malaria treatment, but their efficacy is threatened by the emergence of resistant Plasmodium falciparum strains. While the role of Pfkelch13 mutations in clinical resistance is well establ…
View article: Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining Open
Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this method tends to be time- a…
View article: Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining Open
The identification of novel drug targets for the purpose of designing small molecule inhibitors is key component to modern drug discovery. In malaria parasites, discoveries of antimalarial targets have primarily occurred retroactively by i…
View article: CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection
CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection Open
View article: Artemisinin resistance mutations in<i>Pfcoronin</i>impede hemoglobin uptake
Artemisinin resistance mutations in<i>Pfcoronin</i>impede hemoglobin uptake Open
Artemisinin (ART) combination therapies have been critical in reducing malaria morbidity and mortality, but these important drugs are threatened by growing resistance associated with mutations in Pfcoronin and Pfkelch13 . Here, we describe…
View article: Essential function of alveolin <i>Pf</i> IMC1g in the <i>Plasmodium falciparum</i> asexual blood stage
Essential function of alveolin <i>Pf</i> IMC1g in the <i>Plasmodium falciparum</i> asexual blood stage Open
The cytoskeleton of Plasmodium parasites is essential for replication, motility, and infectivity. Plasmodium falciparum leverages a family of cytoskeletal proteins known as alveolins to meet these diverse needs. The functional role of indi…
View article: Functional profiling of the<i>Toxoplasma</i>genome during acute mouse infection
Functional profiling of the<i>Toxoplasma</i>genome during acute mouse infection Open
SUMMARY Within a host, pathogens encounter a diverse and changing landscape of cell types, nutrients, and immune responses. Examining host-pathogen interactions in animal models can therefore reveal aspects of infection absent from cell cu…