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View article: Adversarial Spatio-Temporal Attention Networks for Epileptic Seizure Forecasting
Adversarial Spatio-Temporal Attention Networks for Epileptic Seizure Forecasting Open
Forecasting epileptic seizures from multivariate EEG signals represents a critical challenge in healthcare time series prediction, requiring high sensitivity, low false alarm rates, and subject-specific adaptability. We present STAN, an Ad…
View article: Spatio-Temporal Attention Network for Epileptic Seizure Prediction
Spatio-Temporal Attention Network for Epileptic Seizure Prediction Open
In this study, we present a deep learning framework that learns complex spatio-temporal correlation structures of EEG signals through a Spatio-Temporal Attention Network (STAN) for accurate predictions of onset of seizures for Epilepsy pat…
View article: Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy Open
View article: Treatment Response to Antiseizure Medications in People With Newly Diagnosed Focal Epilepsy
Treatment Response to Antiseizure Medications in People With Newly Diagnosed Focal Epilepsy Open
Importance Epilepsy affects approximately 65 million people worldwide, and 60% have focal seizures. Predicting seizure response and drug resistance to antiseizure medications (ASMs) in people with focal epilepsy remains difficult. Objectiv…
View article: Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study
Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study Open
Objective We investigated whether complete blood count (CBC) analyses during intensive care unit stay could predict 12‐month outcomes in patients with cryptogenic febrile infection–related epilepsy syndrome (FIRES), a subset of new‐onset r…
View article: Use of Paired Vagus Nerve Stimulation in Mobilization of Patients with Prolonged Disorders of Consciousness: Protocol for a Single Cohort Open Label Interventional Study
Use of Paired Vagus Nerve Stimulation in Mobilization of Patients with Prolonged Disorders of Consciousness: Protocol for a Single Cohort Open Label Interventional Study Open
Introduction Severe acquired brain injury (SABI) is a significant global health concern that can lead to prolonged disorders of consciousness (pDOC). Rehabilitation in the current standard of care is limited to sensory stimulation interven…
View article: Clinical Decisions Without EEG: High Anti-Seizure Medication Use Before EEG in Infants and Its Implications
Clinical Decisions Without EEG: High Anti-Seizure Medication Use Before EEG in Infants and Its Implications Open
Neonatal seizures are challenging to diagnose due to subtle clinical presentations and require video-EEG for confirmatory diagnosis. However, video-EEG is not always available, so clinicians must sometimes decide to treat neonatal seizures…
View article: Corrigendum to ‘The thalamus: Structure, function, and neurotherapeutics’
Corrigendum to ‘The thalamus: Structure, function, and neurotherapeutics’ Open
View article: Pose AI prediction of neurological status in the Neuroscience Intensive Care Unit
Pose AI prediction of neurological status in the Neuroscience Intensive Care Unit Open
BACKGROUND The neurological exam is pivotal in assessing patients with neurological conditions but has severe limitations: it can vary between examiners, it may not discern subtle or subacute changes, and because it is intermittent can del…
View article: Seizures and stigmas: Double burden on transgender health
Seizures and stigmas: Double burden on transgender health Open
View article: The thalamus: Structure, function, and neurotherapeutics
The thalamus: Structure, function, and neurotherapeutics Open
The complexity and expansive nature of thalamic research has led to numerous interventions for varied disease states. At the same time, this complexity along with siloed areas of study can hinder a comprehensive understanding. The goal of …
View article: Detection of neurologic changes in critically ill infants using deep learning on video data: a retrospective single center cohort study
Detection of neurologic changes in critically ill infants using deep learning on video data: a retrospective single center cohort study Open
View article: Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes Open
View article: Accurate prediction of neurologic changes in critically ill infants using pose AI
Accurate prediction of neurologic changes in critically ill infants using pose AI Open
Infant alertness and neurologic changes can reflect life-threatening pathology but are assessed by exam, which can be intermittent and subjective. Reliable, continuous methods are needed. We hypothesized that our computer vision method to …
View article: Elevated phase amplitude coupling as a depression biomarker in epilepsy
Elevated phase amplitude coupling as a depression biomarker in epilepsy Open
View article: Accurate Prediction of Neurologic Changes in Critically Ill Infants with Deep Learning on Video Data
Accurate Prediction of Neurologic Changes in Critically Ill Infants with Deep Learning on Video Data Open
View article: Segmentation and quantification of venous structures and perivascular spaces in the thalamus in epilepsy using 7 Tesla MRI
Segmentation and quantification of venous structures and perivascular spaces in the thalamus in epilepsy using 7 Tesla MRI Open
Background and purpose: Epilepsy is a complex neurological disorder affecting 50 million people worldwide. Persistent seizures may correlate with neural network, microstructural, and vascular changes within the thalamus. These thalamic cha…
View article: A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation
A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation Open
Introduction For drug resistant epilepsy patients who are either not candidates for resective surgery or have already failed resective surgery, neuromodulation is a promising option. Neuromodulatory approaches include responsive neurostimu…
View article: Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy Open
In patients with newly diagnosed focal epilepsy, the prevalence of mood, anxiety disorders, and suicidality is higher than in the general population and comparable to those of patients with established epilepsy. Their recognition at the ti…
View article: Responsive Neurostimulation of the Thalamus for the Treatment of Refractory Epilepsy
Responsive Neurostimulation of the Thalamus for the Treatment of Refractory Epilepsy Open
Introduction One-third of patients with epilepsy continue to have seizures despite antiepileptic medications. Some of these refractory patients may not be candidates for surgical resection primarily because the seizure onset zones (SOZs) i…
View article: Refractory Seizures Secondary to Vitamin B6 Deficiency in Parkinson Disease: The Role of Carbidopa-Levodopa
Refractory Seizures Secondary to Vitamin B6 Deficiency in Parkinson Disease: The Role of Carbidopa-Levodopa Open
Carbidopa-levodopa has been used for more than 50 years in the treatment of Parkinson disease (PD) and other movement disorders. Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6 (pyridoxine), is involved in the decarboxylation of…
View article: Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19
Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19 Open
View article: Quantification of brain age using high-resolution 7 tesla MR imaging and implications for patients with epilepsy
Quantification of brain age using high-resolution 7 tesla MR imaging and implications for patients with epilepsy Open
Morphological patterns suggestive of premature aging were observed in non-lesional epilepsy patients vs. controls and in high seizure frequency patients vs. low frequency patients. Modeling brain age with 7T MRI may provide a sensitive ima…
View article: Detection of Hippocampal Subfield Asymmetry at 7T With Automated Segmentation in Epilepsy Patients With Normal Clinical Strength MRIs
Detection of Hippocampal Subfield Asymmetry at 7T With Automated Segmentation in Epilepsy Patients With Normal Clinical Strength MRIs Open
While the etiology of hippocampal sclerosis (HS) in epilepsy patients remains unknown, distinct phenotypes of hippocampal subfield atrophy have been associated with different clinical presentations and surgical outcomes. The advent of nove…
View article: Deep Learning of Simultaneous Intracranial and Scalp EEG for Prediction, Detection, and Lateralization of Mesial Temporal Lobe Seizures
Deep Learning of Simultaneous Intracranial and Scalp EEG for Prediction, Detection, and Lateralization of Mesial Temporal Lobe Seizures Open
In people with drug resistant epilepsy (DRE), seizures are unpredictable, often occurring with little or no warning. The unpredictability causes anxiety and much of the morbidity and mortality of seizures. In this work, 102 seizures of mes…
View article: Teaching NeuroImage: Human Polymerase Gamma Gene ( <i>POLG</i> ) Disorder Presenting as Refractory Status Epilepticus
Teaching NeuroImage: Human Polymerase Gamma Gene ( <i>POLG</i> ) Disorder Presenting as Refractory Status Epilepticus Open
A 31-year-old woman with severe childhood-onset dysmotility syndrome was admitted for encephalopathy and seizures. Video EEG demonstrated electrographic seizures of multifocal onset refractory to multiple antiseizure medications (figure 1,…
View article: Brief potentially ictal rhythmic discharges and paroxysmal fast activity as scalp electroencephalographic biomarkers of seizure activity and seizure onset zone
Brief potentially ictal rhythmic discharges and paroxysmal fast activity as scalp electroencephalographic biomarkers of seizure activity and seizure onset zone Open
Objective The electroencephalographic (EEG) terms “brief potentially ictal rhythmic discharges” (BIRDs) and “paroxysmal fast activity” (PFA) are considered distinct entities; however, their definitions overlap, and they may have similar cl…
View article: Utility of 7 tesla MRI brain in 16 “MRI Negative” epilepsy patients and their surgical outcomes
Utility of 7 tesla MRI brain in 16 “MRI Negative” epilepsy patients and their surgical outcomes Open
View article: Psychiatric comorbidities, sexual health and neurodevelopmental outcomes of offspring in men with epilepsy
Psychiatric comorbidities, sexual health and neurodevelopmental outcomes of offspring in men with epilepsy Open
View article: Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism
Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism Open
The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug‐resistant epilepsy secondary to Lennox‐Gastaut …