Madeline P. Hopps
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View article: Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction
Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction Open
Myocardial infarction (MI) results in oxidative stress to the myocardium and frequently leads to heart failure (HF). There is an unmet clinical need to develop therapeutics that address the inflammatory stress response and prevent negative…
View article: Inhibiting the Keap1/Nrf2 Protein‐Protein Interaction with Protein‐Like Polymers
Inhibiting the Keap1/Nrf2 Protein‐Protein Interaction with Protein‐Like Polymers Open
Successful and selective inhibition of the cytosolic protein‐protein interaction (PPI) between nuclear factor erythroid 2‐related factor 2 (Nrf2) and Kelch‐like ECH‐associating protein 1 (Keap1) can enhance the antioxidant response, with t…