Mohit H. Adhikari
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View article: Imaging brain development in a KCNQ2-developmental and epileptic encephalopathy mouse model: identifying early biomarkers for functional and structural brain changes
Imaging brain development in a KCNQ2-developmental and epileptic encephalopathy mouse model: identifying early biomarkers for functional and structural brain changes Open
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View article: Longitudinal investigation of structural and resting-state effective connectivity alterations in a non-human primate model of Huntington's disease
Longitudinal investigation of structural and resting-state effective connectivity alterations in a non-human primate model of Huntington's disease Open
Huntington's disease (HD) is a genetic neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene which produce a mutant huntingtin (mHTT) protein that contributes to progressive striatal, cortical, and white-matter a…
View article: Long-term dietary interventions fail to mitigate functional connectivity loss and cognitive decline in the TgF344-AD rat model of Alzheimer’s Disease
Long-term dietary interventions fail to mitigate functional connectivity loss and cognitive decline in the TgF344-AD rat model of Alzheimer’s Disease Open
Introduction Alzheimer’s disease (AD) is a complex neurodegenerative disorder, characterized by altered brain functional connectivity and network activity, detectable using resting-state functional MRI (rsfMRI). Caloric restriction (CR) an…
View article: Longitudinal Investigation of Structural and Resting-State Effective Connectivity Alterations in a Non-Human Primate Model of Huntington’s Disease
Longitudinal Investigation of Structural and Resting-State Effective Connectivity Alterations in a Non-Human Primate Model of Huntington’s Disease Open
Huntington’s disease (HD) is a genetic neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene which produce a mutant huntingtin (mHTT) protein that contributes to progressive striatal, cortical, and white-matter a…
View article: Resting-state functional dynamics alterations relate to plasma amyloid markers and explain memory impairments in the TgF344-AD model of Alzheimer’s disease
Resting-state functional dynamics alterations relate to plasma amyloid markers and explain memory impairments in the TgF344-AD model of Alzheimer’s disease Open
Resting-state (RS) fMRI studies of Alzheimer’s disease’s (AD) impact on brain function commonly use functional connectivity (FC), ignoring short-timescale network dynamics, captured by co-activation patterns (CAPs), shown to accurately cla…
View article: Tracking brain maturation in vivo: functional connectivity, white matter integrity, and synaptic density in developing mice
Tracking brain maturation in vivo: functional connectivity, white matter integrity, and synaptic density in developing mice Open
View article: Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats
Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats Open
Introduction Dietary interventions such as caloric restriction (CR) exert positive effects on brain health. Unfortunately, poor compliance hinders the success of this approach. A proposed alternative is resveratrol (Rsv), a CR-mimetic know…
View article: Imaging Brain Development in a KCNQ2-Developmental and Epileptic Encephalopathy Mouse Model: Identifying Early Biomarkers for Functional and Structural Brain Changes
Imaging Brain Development in a KCNQ2-Developmental and Epileptic Encephalopathy Mouse Model: Identifying Early Biomarkers for Functional and Structural Brain Changes Open
View article: Evolution of aberrant brain‐wide spatiotemporal dynamics of resting‐state networks in a Huntington's disease mouse model
Evolution of aberrant brain‐wide spatiotemporal dynamics of resting‐state networks in a Huntington's disease mouse model Open
Background Huntington's disease (HD) is marked by irreversible loss of neuronal function for which currently no availability for disease‐modifying treatment exists. Advances in the understanding of disease progression can aid biomarker dev…
View article: A Comparative Analysis of Support Vector Machines, Decision Trees, and Long Short-Term Memory Networks in Phishing Website Detection
A Comparative Analysis of Support Vector Machines, Decision Trees, and Long Short-Term Memory Networks in Phishing Website Detection Open
View article: Early altered directionality of resting brain network state transitions in the TgF344-AD rat model of Alzheimer's disease
Early altered directionality of resting brain network state transitions in the TgF344-AD rat model of Alzheimer's disease Open
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disease resulting in memory loss and cognitive decline. Synaptic dysfunction is an early hallmark of the disease whose effects on whole-brain functional architecture …
View article: Early altered directionality of resting brain network state transitions in the TgF344-AD rat model of Alzheimer’s disease
Early altered directionality of resting brain network state transitions in the TgF344-AD rat model of Alzheimer’s disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disease resulting in memory loss and cognitive decline. Synaptic dysfunction is an early hallmark of the disease whose effects on whole-brain functional architecture can be identi…
View article: Tracking Brain Maturation in Vivo: Functional Connectivity, White Matter Integrity, and Synaptic Density in Developing Mice
Tracking Brain Maturation in Vivo: Functional Connectivity, White Matter Integrity, and Synaptic Density in Developing Mice Open
View article: Evolution of aberrant brain-wide spatiotemporal dynamics of resting-state networks in a Huntington’s disease mouse model
Evolution of aberrant brain-wide spatiotemporal dynamics of resting-state networks in a Huntington’s disease mouse model Open
Distinct resting-state networks (RSNs) are differentially altered in the course of Huntington’s disease (HD). However, these RSN changes are depicted using traditional functional connectivity analyses which ignore the dynamic brain states …
View article: Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease Open
View article: Resting-state fMRI reveals longitudinal alterations in brain network connectivity in the zQ175DN mouse model of Huntington's disease
Resting-state fMRI reveals longitudinal alterations in brain network connectivity in the zQ175DN mouse model of Huntington's disease Open
Huntington's disease is an autosomal, dominantly inherited neurodegenerative disease caused by an expansion of the CAG repeats in exon 1 of the huntingtin gene. Neuronal degeneration and dysfunction that precedes regional atrophy result in…
View article: Resting-State fMRI reveals Longitudinal Alterations in Brain Network Connectivity in the zQ175DN mouse Model of Huntington's Disease
Resting-State fMRI reveals Longitudinal Alterations in Brain Network Connectivity in the zQ175DN mouse Model of Huntington's Disease Open
Background: Huntington's diseaseis an autosomal, dominantly inherited neurodegenerative disease caused by an expansion of the CAG repeats in exon 1 of the huntingtin gene. Neuronal degeneration and dysfunction that precedes regional atroph…
View article: Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease Open
Huntington’s disease (HD) is a neurodegenerative disorder caused by expanded (≥ 40) glutamine-encoding CAG repeats in the huntingtin gene, which leads to dysfunction and death of predominantly striatal and cortical neurons. While the genet…
View article: Identification of pre-synaptic density networks using [11C]UCB-J PET imaging and ICA in mice
Identification of pre-synaptic density networks using [11C]UCB-J PET imaging and ICA in mice Open
View article: Resting-State fMRI reveals Longitudinal Alterations in Brain Network Connectivity in a Mouse Model of Huntington’s Disease
Resting-State fMRI reveals Longitudinal Alterations in Brain Network Connectivity in a Mouse Model of Huntington’s Disease Open
Huntington’s disease is an autosomal, dominantly inherited neurodegenerative disease caused by an expansion of the CAG repeats in exon 1 of the huntingtin gene. Neuronal degeneration and dysfunction that precedes regional atrophy result in…
View article: Identification of pre-synaptic density networks using SV2A PET imaging and ICA in healthy and diseased mice
Identification of pre-synaptic density networks using SV2A PET imaging and ICA in healthy and diseased mice Open
Background Synaptic vesicle glycoprotein 2A (SV2A) is a vesicle glycoprotein involved in neurotransmitter release. SV2A is located on the pre-synaptic terminals of neurons and visualized using the radioligand [ 11 C]UCB-J and positron emis…
View article: Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats
Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats Open
Background Imbalanced synaptic transmission appears to be an early driver in Alzheimer’s disease (AD) leading to brain network alterations. Early detection of altered synaptic transmission and insight into mechanisms causing early synaptic…
View article: Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease Open
Huntington’s disease (HD) is a neurodegenerative disorder caused by expanded (≥40) glutamine-encoding CAG repeats in the huntingtin gene, which leads to dysfunction and death of predominantly striatal and cortical neurons. While the geneti…
View article: Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats
Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats Open
Background: Imbalanced synaptic transmission appears to be an early driver in Alzheimer’s Disease (AD) leading to brain network alterations. Early detection of altered synaptic transmission and insight into mechanisms causing early synapti…
View article: Advancing brain network models to reconcile functional neuroimaging and clinical research
Advancing brain network models to reconcile functional neuroimaging and clinical research Open
View article: Comparative Analysis of Fake Review Monitoring and Detection using Logistic Regression, Decision Tree, Support Vector Machine
Comparative Analysis of Fake Review Monitoring and Detection using Logistic Regression, Decision Tree, Support Vector Machine Open
View article: Effective connectivity extracts clinically relevant prognostic information from resting state activity in stroke
Effective connectivity extracts clinically relevant prognostic information from resting state activity in stroke Open
Recent resting-state functional MRI studies in stroke patients have identified two robust biomarkers of acute brain dysfunction: a reduction of inter-hemispheric functional connectivity between homotopic regions of the same network, and an…
View article: Advancing brain network models to reconcile functional neuroimaging and clinical research
Advancing brain network models to reconcile functional neuroimaging and clinical research Open
Functional magnetic resonance imaging (fMRI) captures information on brain function beyond anatomical alterations traditionally visible to neuroradiologists. However, the fMRI signal is complex and noisy, and so far fMRI has brought limite…
View article: Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice
Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice Open
Alzheimer’s disease (AD), a neurodegenerative disorder marked by accumulation of extracellular amyloid-β (Aβ) plaques leads to progressive loss of memory and cognitive function. Resting-state fMRI (RS-fMRI) studies have provided links betw…
View article: Effective connectivity extracts clinically relevant prognostic information from resting state activity in stroke
Effective connectivity extracts clinically relevant prognostic information from resting state activity in stroke Open
Recent resting-state fMRI studies in stroke patients have identified two robust biomarkers of acute brain dysfunction: a reduction of inter-hemispheric functional connectivity (FC) between homotopic regions of the same network, and an abno…