Madhavi Dipak Andhari
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View article: CONCLAVE: CONsensus CLustering with Annotation-Validation Extrapolation for cyclic multiplexed immunofluorescence data
CONCLAVE: CONsensus CLustering with Annotation-Validation Extrapolation for cyclic multiplexed immunofluorescence data Open
High-dimensional cyclic multiplexed immunofluorescence (cMIF) enables single-cell phenotyping within intact tissues. Cell annotations rely on a multi-step pipeline involving normalization, sampling, dimensionality reduction, and clustering…
View article: Quality control of immunofluorescence images using artificial intelligence
Quality control of immunofluorescence images using artificial intelligence Open
View article: QUAL-IF-AI: Quality Control of Immunofluorescence Images using Artificial Intelligence
QUAL-IF-AI: Quality Control of Immunofluorescence Images using Artificial Intelligence Open
Fluorescent imaging has revolutionized biomedical research, enabling the study of intricate cellular processes. Multiplex immunofluorescent imaging has extended this capability, permitting the simultaneous detection of multiple markers wit…
View article: 1167P Spatial and single cell landscaping of immune microenvironment and melanoma subpopulations of metastasizing and non-metastasizing early-stage melanomas
1167P Spatial and single cell landscaping of immune microenvironment and melanoma subpopulations of metastasizing and non-metastasizing early-stage melanomas Open
View article: Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma
Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma Open
Background Loss of Ambra1 (autophagy and beclin 1 regulator 1), a multifunctional scaffold protein, promotes the formation of nevi and contributes to several phases of melanoma development. The suppressive functions of Ambra1 in melanoma a…
View article: Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications
Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications Open
The state-of-the-art for melanoma treatment has recently witnessed an enormous revolution, evolving from a chemotherapeutic, “one-drug-for-all” approach, to a tailored molecular- and immunological-based approach with the potential to make …