Madhu Nagaraj
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View article: CsgA gatekeeper residues control nucleation but not stability of functional amyloid
CsgA gatekeeper residues control nucleation but not stability of functional amyloid Open
Functional amyloids, beneficial to the organism producing them, are found throughout life, from bacteria to humans. While disease‐related amyloids form by uncontrolled aggregation, the fibrillation of functional amyloid is regulated by com…
View article: Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain
Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain Open
It is not well understood why severe acute respiratory syndrome (SARS)-CoV-2 spreads much faster than other β-coronaviruses such as SARS-CoV and Middle East respiratory syndrome (MERS)-CoV. In a previous publication, we predicted the bindi…
View article: Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation
Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation Open
View article: Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions
Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions Open
The toxic α-synuclein oligomer (αSO) is an important drug target. Neuronal proteins found by pull-down assays do not bind αSO in solution. A liposome assay identifies 7 drugs reducing αSO membrane disruption, of which 2 disrupt αSO-antibod…
View article: Drug repurposing screens identifies compounds that inhibit α-synuclein oligomers’ membrane disruption and block antibody interactions
Drug repurposing screens identifies compounds that inhibit α-synuclein oligomers’ membrane disruption and block antibody interactions Open
Small soluble oligomers of the protein α-synuclein (αSO) have been linked to disruptions in neuronal homeostasis, contributing to the development of Parkinson’s Disease (PD). While this makes αSO an obvious drug target, the development of …
View article: Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation
Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation Open
Unlike misfolding in neurodegenerative diseases, aggregation of functional amyloids involved in bacterial biofilm, e.g. CsgA ( E. coli ) and FapC ( Pseudomonas ), is carefully regulated.
View article: A semi high-throughput method for real-time monitoring of curli producing Salmonella biofilms on air-solid interfaces
A semi high-throughput method for real-time monitoring of curli producing Salmonella biofilms on air-solid interfaces Open
View article: Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential Open
View article: Structural and functional characterization of the Curli adaptor protein CsgF
Structural and functional characterization of the Curli adaptor protein CsgF Open
Curli are functional amyloids that form a major part of the biofilm produced by many enterobacteriaceae. A multiprotein system around the outer membrane protein CsgG is in charge of the export and controlled propagation of the main Curli s…
View article: CD36 contributes to IRBC-induced pro-inflammatory cytokine production by DCs.
CD36 contributes to IRBC-induced pro-inflammatory cytokine production by DCs. Open
FL-DCs from WT and Cd36−/− mice were stimulated with the indicated doses of CD36-adherent IRBCs (AI) and CD36-nonadherent IRBCs (NAI) for 24 h. WT DCs stimulated with RBCs, and WT DCs and Cd36−/− DCs sti…
View article: CD36 contributes to the IFN-γ production by NK cells stimulated with IRBC-treated DCs.
CD36 contributes to the IFN-γ production by NK cells stimulated with IRBC-treated DCs. Open
NK cells from WT and Cd36−/− mice co-cultured with WT and Cd36−/− FL-DCs and then stimulated with CD36-adherent IRBCs (AI) or CD36-nonadherent IRBCs (NAI) for 36 h. DCs and NK cells alone stimulated with…