Madhukar S. Said
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View article: Chemical hydrodynamics of nuclear spin states
Chemical hydrodynamics of nuclear spin states Open
Quantum mechanical equations of motion are strictly linear in density operators, but equations describing chemical kinetics and hydrodynamics may be nonlinear in concentrations. This incompatibility is fundamental, but special cases can be…
View article: Optimizing Cell Density and Unveiling Cytotoxic Profiles of DMSO and Ethanol in Six Cancer Cell Lines: Experimental and In Silico Insights
Optimizing Cell Density and Unveiling Cytotoxic Profiles of DMSO and Ethanol in Six Cancer Cell Lines: Experimental and In Silico Insights Open
Background: Accurate assessment of drug cytotoxicity in vitro is essential for preclinical evaluation of anticancer agents. Methodological parameters such as cell density and solvent concentrations can significantly influence the reproduci…
View article: Chemical hydrodynamics of nuclear spin states
Chemical hydrodynamics of nuclear spin states Open
Quantum mechanical equations of motion are strictly linear in state descriptors, such as wavefunctions and density matrices, but equations describing chemical kinetics and hydrodynamics may be non-linear in concentrations. This incompatibi…
View article: Antioxidant, Enzyme and Molecular Docking Tyrosinase Inhibitory Activities of Major Polyphenols in <i>Boscia coriacea</i> Graells, <i>Grewia erythraea</i> (Schweinf.) Chiov., <i>Ochradenus baccatus</i> Delile, and <i>Orthosiphon pallidus</i> Royle Ex Benth.
Antioxidant, Enzyme and Molecular Docking Tyrosinase Inhibitory Activities of Major Polyphenols in <i>Boscia coriacea</i> Graells, <i>Grewia erythraea</i> (Schweinf.) Chiov., <i>Ochradenus baccatus</i> Delile, and <i>Orthosiphon pallidus</i> Royle Ex Benth. Open
Boscia coriacea Graells (BC), Grewia erythraea (Schweinf.) Chiov. (GE), Ochradenus baccatus Delile (OB), and Orthosiphon pallidus Royle ex Benth. (OP) are medicinal plants used in Djibouti. They were evaluated to determine their total phen…
View article: Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency
Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency Open
The NLRP3 inflammasome plays a central role in various human diseases. Despite significant interest, most clinical-grade NLRP3 inhibitors are derived from sulfonylurea inhibitor CRID3 (also called MCC950). Here, we describe a novel chemica…
View article: Organocatalytic Route to the Enantioselective Synthesis of Syn/Anti-Α-Hydrazino-ℽ-Fluoro Alcohols
Organocatalytic Route to the Enantioselective Synthesis of Syn/Anti-Α-Hydrazino-ℽ-Fluoro Alcohols Open
View article: Correction to: Antifungal compound from marine Serratia marcescens BKACT and its potential activity against Fusarium sp.
Correction to: Antifungal compound from marine Serratia marcescens BKACT and its potential activity against Fusarium sp. Open
View article: Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection
Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection Open
Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects. Thus, there is a continuous need to explore safe and efficacious anti-retr…
View article: 2,4-Di-tert-butylphenol (2,4-DTBP) purified from Streptomyces sp. KCA1 from Phyllanthus niruri: Isolation, characterization, antibacterial and anticancer properties
2,4-Di-tert-butylphenol (2,4-DTBP) purified from Streptomyces sp. KCA1 from Phyllanthus niruri: Isolation, characterization, antibacterial and anticancer properties Open
Objectives: The present study reports the bioactivity of 2,4-Di-tert-butylphenol (2,4-DTBP) purified from an endophytic Streptomyces species KCA1 isolated from the leaves of Phyllanthus niruri and its antibacterial and anticancer propertie…
View article: Antifungal compound from marine Serratia marcescens BKACT and its potential activity against Fusarium sp.
Antifungal compound from marine Serratia marcescens BKACT and its potential activity against Fusarium sp. Open
Ecofriendly biocontrol agents to control of pathogenic fungi are in demand globally. The present study was evaluated the antifungal potentials of marine bacteria Serratia marcescens BKACT against eight different Fusarium species. A highest…
View article: CCDC 1946291: Experimental Crystal Structure Determination
CCDC 1946291: Experimental Crystal Structure Determination Open
View article: CCDC 1946293: Experimental Crystal Structure Determination
CCDC 1946293: Experimental Crystal Structure Determination Open
View article: Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials
Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials Open
The first total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate (butenolide cinnamate) was achieved using commercially available starting material. The synthesized compound was found to have promising antibacterial activity against Gra…
View article: Approach to nigericin derivatives and their therapeutic potential
Approach to nigericin derivatives and their therapeutic potential Open
A new nigericin analogue that has been chemically modified was synthesized through a fluorination process from the parent nigericin, produced from a novel Streptomyces strain DASNCL-29.
View article: Retraction: Synthesis of deuterated isopentyl pyrophosphates for chemo-enzymatic labelling methods: GC-EI-MS based 1,2-hydride shift in epicedrol biosynthesis
Retraction: Synthesis of deuterated isopentyl pyrophosphates for chemo-enzymatic labelling methods: GC-EI-MS based 1,2-hydride shift in epicedrol biosynthesis Open
Retraction of ‘Synthesis of deuterated isopentyl pyrophosphates for chemo-enzymatic labelling methods: GC-EI-MS based 1,2-hydride shift in epicedrol biosynthesis’ by Madhukar S. Said et al., RSC Adv., 2019, 9, 28258–28261.
View article: CCDC 1949533: Experimental Crystal Structure Determination
CCDC 1949533: Experimental Crystal Structure Determination Open
View article: CCDC 1949387: Experimental Crystal Structure Determination
CCDC 1949387: Experimental Crystal Structure Determination Open
View article: CCDC 1949532: Experimental Crystal Structure Determination
CCDC 1949532: Experimental Crystal Structure Determination Open
View article: CCDC 1949386: Experimental Crystal Structure Determination
CCDC 1949386: Experimental Crystal Structure Determination Open
View article: Enhancing <i>epi</i>‐cedrol production in <i>Escherichia coli</i> by fusion expression of farnesyl pyrophosphate synthase and <i>epi</i>‐cedrol synthase
Enhancing <i>epi</i>‐cedrol production in <i>Escherichia coli</i> by fusion expression of farnesyl pyrophosphate synthase and <i>epi</i>‐cedrol synthase Open
Terpene synthase catalyses acyclic diphosphate farnesyl diphosphate into desired sesquiterpenes. In this study, a fusion enzyme was constructed by linking Santalum album farnesyl pyrophosphate synthase ( SaFPPS ) individually with terpene …
View article: Retracted Article: Synthesis of deuterated isopentyl pyrophosphates for chemo-enzymatic labelling methods: GC-EI-MS based 1,2-hydride shift in epicedrol biosynthesis
Retracted Article: Synthesis of deuterated isopentyl pyrophosphates for chemo-enzymatic labelling methods: GC-EI-MS based 1,2-hydride shift in epicedrol biosynthesis Open
The cyclisation mechanism of epicedrol cyclase elucidated based on GC-EI-MS fragmentation of specific deuterated (2H) epicedrol analogues. The chemo-enzymatic method was applied for the synthesis 8-position-2H-farnesy…