Manoj Kumar Kashyap
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View article: RETRACTED: Comparative Analysis of ANN, RNN, and GRU for Credit Card Fraud Detection
RETRACTED: Comparative Analysis of ANN, RNN, and GRU for Credit Card Fraud Detection Open
The authors have requested that this preprint be removed from Research Square.
View article: RETRACTED: Comparative Analysis of ANN, RNN, and GRU for Credit Card Fraud Detection
RETRACTED: Comparative Analysis of ANN, RNN, and GRU for Credit Card Fraud Detection Open
The authors have requested that this preprint be removed from Research Square.
View article: Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia
Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia Open
Splicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a …
View article: Editorial: Linking cellular metabolism to hematological malignancies, volume II
Editorial: Linking cellular metabolism to hematological malignancies, volume II Open
Keywords: ferroptosis, multiple myeloma, lipid reprogramming, RNA-Seq, Reactive oxygen active (ROS), leukemia
View article: Non-alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-analysis from an Omics Perspective
Non-alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-analysis from an Omics Perspective Open
Background and objectivesNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed countries, contributing to ∼24% of cases worldwide and includes non-alcoholic steatohepatitis. NAFLD is characterized …
View article: Editorial: Exosomes, miRNAs, and lncRNAs in breast cancer: Therapeutic and diagnostic applications
Editorial: Exosomes, miRNAs, and lncRNAs in breast cancer: Therapeutic and diagnostic applications Open
Breast cancer is a complex disease that can be influenced by a variety of factors, including genetics, lifestyle, and environmental factors. It is classified into different subtypes based on the presence or absence of hormone receptors and…
View article: Editorial: Linking cellular metabolism to hematological malignancies
Editorial: Linking cellular metabolism to hematological malignancies Open
EDITORIAL article Front. Oncol., 11 November 2022Sec. Cancer Metabolism Volume 12 - 2022 | https://doi.org/10.3389/fonc.2022.1077358
View article: Dysregulated Spliceosome Activity Involves Increased Intron Retention Plus Upregulation and Phosphorylation of SF3B1 in Chronic Lymphocytic Leukemia
Dysregulated Spliceosome Activity Involves Increased Intron Retention Plus Upregulation and Phosphorylation of SF3B1 in Chronic Lymphocytic Leukemia Open
Background Alternative splicing (AS) is a fundamental process in eukaryotes contributing to the diversity of mRNA isoforms with variable ratios of intron/exon. SF3B1 is a pivotal protein of the spliceosome machinery. Mutations in the SF3B1…
View article: Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B
Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B Open
Alterations in RNA splicing are associated with different malignancies, including leukemia, lymphoma, and solid tumors. The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies to targe…
View article: Additional file 11 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment
Additional file 11 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment Open
Additional file 11.
View article: Additional file 9 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment
Additional file 9 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment Open
Additional file 9: File S4. Reactome analyses of proteins and phosphoproteins identified by mass spectrometric characterization of EVs secreted from cell culture conditions.
View article: Additional file 12 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment
Additional file 12 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment Open
Additional file 12.
View article: Additional file 10 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment
Additional file 10 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment Open
Additional file 10: File S5. Design and details of donor samples used to construct the Hybrid TMA for rapid validation of biomarkers identified in mass spectrometric studies.
View article: Additional file 7 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment
Additional file 7 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment Open
Additional file 7: File S2. Clusters identified in the proteome and phosphoproteome in EVs. Only those proteins were considered as identified hits, which had three values in any one triplicate condition.
View article: Additional file 6 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment
Additional file 6 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment Open
Additional file 6: File S1. Proteome Discoverer Output of identified proteins and phosphoproteins with comprehensive list of peptides detected by mass spectrometry.
View article: FD-895 and Pladienolide B Modulate RNA Splicing Associated With Wnt Signaling Pathway
FD-895 and Pladienolide B Modulate RNA Splicing Associated With Wnt Signaling Pathway Open
BackgroundAlterations in RNA splicing are associated with different malignancies including leukemia, lymphoma, and solid tumors. The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies…
View article: Additional file 1 of Tumor reversion: a dream or a reality
Additional file 1 of Tumor reversion: a dream or a reality Open
Additional file 1.
View article: Editorial: Multi-Omics Approaches to Study Signaling Pathways
Editorial: Multi-Omics Approaches to Study Signaling Pathways Open
EDITORIAL article Front. Bioeng. Biotechnol., 04 September 2020Sec. Computational Genomics Volume 8 - 2020 | https://doi.org/10.3389/fbioe.2020.00829
View article: COVID-19: A landscape of treatment options from Convalescent plasma therapy to the repurposing of the drugs and the challenges ahead
COVID-19: A landscape of treatment options from Convalescent plasma therapy to the repurposing of the drugs and the challenges ahead Open
Since the first case reports in Wuhan, China, SARS-CoV-2 virus took lives of >6,85,000 people all around the world. This single stranded RNA virus used Angiotensin converting enzyme 2 (ACE2) as a receptor for entry into the host cell. O…
View article: ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma
ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma Open
Esophageal cancer (EC) is the eighth most aggressive malignancy and its treatment remains a challenge due to the lack of biomarkers that can facilitate early detection. EC is identified in two major histological forms namely - Adenocarcino…
View article: Expression, regulation and targeting of receptor tyrosine kinases in esophageal squamous cell carcinoma
Expression, regulation and targeting of receptor tyrosine kinases in esophageal squamous cell carcinoma Open
View article: Identification of spleen tyrosine kinase as a potential therapeutic target for esophageal squamous cell carcinoma using reverse phase protein arrays
Identification of spleen tyrosine kinase as a potential therapeutic target for esophageal squamous cell carcinoma using reverse phase protein arrays Open
The vast majority of esophageal cancers in China, India and Iran are esophageal squamous cell carcinomas (ESCC). A timely diagnosis provides surgical removal as the main therapeutic option for patients with ESCC. Currently, there are no ta…
View article: Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway
Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway Open
The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL). The CXCR4 ligand (CXCL12) stimulates CXCR4 promoting cell survival and prolifer…
View article: Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways
Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways Open
Breast cancer is the most prevalent cancer in women worldwide. About 15-20% of all breast cancers are triple negative breast cancer (TNBC) and are often highly aggressive when compared to other subtypes of breast cancers. To better charact…
View article: Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B
Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B Open
RNA splicing plays a fundamental role in human biology. Its relevance in cancer is rapidly emerging as demonstrated by spliceosome mutations that determine the prognosis of patients with hematologic malignancies. We report studies using FD…